Proteomics in Proximity

Welcome to the Olink® Proteomics in Proximity podcast! 
 

Below are some useful resources mentioned in this episode: 

Reagan-Udall Foundation at FDA Gerotherapeutics in Aging Event Recording available: Affecting the Aging Trajectory:  Regulatory Constructs for Gerotherapeutic Drug, Biologic and Device Development

https://reaganudall.org/news-and-events/events/affecting-aging-trajectory-regulatory-constructs-gerotherapeutic-drug

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 

UK Biobank Pharma Proteomics Project Full Cohort Study:  Thermo Fisher Scientific’s Olink Platform Selected for World’s Largest Human Proteome Study

https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx

Organ Ageing and Ageing Clock Publications leveraging Olink Proteomics:

Oh, H.SH et al. (2025). Plasma proteomics links brain and immune system aging with healthspan and longevity. Nat Med 31, 2703–2711. https://doi.org/10.1038/s41591-025-03798-1

Goeminne et al (2024). Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems Cell Metabolism, 37, 205-222.e6

Argentieri, M.A et al. (2024). Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat Med 30, 2450–2460. https://doi.org/10.1038/s41591-024-03164-7

Additional publication of interest: 

Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens. Kardell O (2023). J Proteome Res. 2024 Jan 5;23(1):117-129. https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00473

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Deezer:

Welcome to the Olink® Proteomics in Proximity podcast!

Below are some useful resources mentioned in this episode:
UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date. https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies

Research articles and news
UK Biobank Pharma Proteomics Project Full Cohort Study:  Thermo Fisher Scientific’s Olink Platform Selected for World’s Largest Human Proteome Study
https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx

Parabiosis
Conboy et al (2005) Rejuvenation of aged progenitor cells by exposure to a young systemic environment.  Nature 433: 760-764. https://www.nature.com/articles/nature03260

Villeda et al. (2011). The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477, 90–94 https://doi.org/10.1038/nature10357

Organ Aging/Ageing Clock Publications leveraging Olink Proteomics
Oh, H.SH et al. (2025). Plasma proteomics links brain and immune system aging with healthspan and longevity. Nat Med 31, 2703–2711. https://doi.org/10.1038/s41591-025-03798-1
Goeminne et al (2025). Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems Cell Metabolism, 37, 205-222.e6
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00401-7
Argentieri, M.A et al. (2024). Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat Med 30, 2450–2460. https://doi.org/10.1038/s41591-024-03164-7

Young blood factors infused into young mice
Villeda et al (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.  Nature Medicine.  20:659-663. https://www.nature.com/articles/nm.3569

Single cell work with Stephen Quake
Pálovics et al (2022). Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature 603:309-314.
https://www.nature.com/articles/s41586-022-04461-2

Andrew Yang, Gladstone Institute labeling of hundreds of endogenous plasma proteins
Yang et al (2020). Physiological blood-brain transport is impaired with age by a shift in transcytosis. Nature 583: 425-430.
https://www.nature.com/articles/s41586-020-2453-z

Eric Topol episode with Tony on Ground Truths
https://erictopol.substack.com/p/tony-wyss-coray-the-science-of-aging

Mike Snyder’s team (Stanford) and the concept of Ageotypes
Ahadi S et al. (2020). Personal aging markers and ageotypes revealed by deep longitudinal profiling. Nature Medicine. 2020;26:83–90. https://www.nature.com/articles/s41591-019-0719-5

Preprint ahead of Nature Medicine paper Tony references coming out weeks after podcast episode
Ding et al (2026; preprint). Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease. bioRxiv
https://www.biorxiv.org/content/10.64898/2026.02.10.704909v1

Vero Biosciences:  Founded with Tony where a consumer can have blood measured, which organs show accelerated aging with clinician input into potential interventions.  https://www.verobioscience.com/

Teal Rise: Founded with Tony, partnering with Olink that has collected a large database to drive model building across diseases and prediction. https://tealrise.com/

Heike A. Bischoff-Ferrari and the Do-Health Trial:
Bischoff-Ferrari et al (2025). Individual and additive effects of vitamin D, omega-3, and exercise on DNA methylation clocks of biological aging in older adults in the Do-Health trial. Nature Aging. 5: 376-385.
https://www.nature.com/articles/s43587-024-00793-y

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Proteomics in Proximity refers to the principle underlying Olink technology called the Proximity Extension Assay (PEA). More information about the assay and how it works can be found here: https://bit.ly/3Rt7YiY

Host:  Cindy Lawley
Co-host: Sarantis Chlamydas
Executive Producer: Cindy Lawley
Editor:  Fredrik Hamfelt, Phosworks
Project Manager: Eva Kellerman, Phosworks

For any questions regarding information Olink Proteomics, please email us at [email protected] or visit our website: https://www.olink.com/

Welcome to the Olink® Proteomics in Proximity podcast! 

Below are some useful resources mentioned in this episode: 

Olink tools and software

·       Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ 

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 

World Health Organization (2003). Adherence to long-term therapies: evidence for action (PDF). 

Geneva: World Health Organisation. ISBN 978-92-4-154599-0

Research articles and news

·       Thermo Fisher Scientific’s Olink Platform Selected for World’s Largest Human Proteome Study

https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx

·       Hamilton Se-Hwee Oh et al 2025. Plasma proteomics links brain and immune system aging with healthspan and longevityhttps://www.nature.com/articles/s41591-025-03798-1. Nature Medicine (2025)

·       Song, Y., Abuduaini, B., Yang, X. et al. Identification of inflammatory protein biomarkers for predicting the different subtype of adult with tuberculosis: an Olink proteomic study. Inflamm. Res. 74, 60 (2025). https://doi.org/10.1007/s00011-025-02020-9

·       Ferhan Qureshi et al 2023. Analytical validation of a multi-protein, serum-based assay for disease activity assessments in multiple sclerosis. Proteomics clinical application 2023

·       Dhindsa, R.S., Burren, O.S., Sun, B.B. et al. Rare variant associations with plasma protein levels in the UK Biobank. 2023 Nature, DOI: 10.1038/s41586-023-06547-x

https://www.nature.com/articles/s41586-023-06547-x

·       Sun, B.B., Chiou, J., Traylor, M. et al.  Plasma proteomic associations with genetics and health in the UK Biobank. 2023 Nature, DOI: 10.1038/s41586-023-06592-6 

https://www.nature.com/articles/s41586-023-06592-6

 https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac495/6676779

·       Eldjarn GH, et al. Large-scale plasma proteomics comparisons through genetics and disease associations. Nature. 2023 Oct;622(7982):348-358. doi: 10.1038/s41586-023-06563-x

https://www.nature.com/articles/s41586-023-06563-x#Sec44

·        Carrasco-Zanini et al 2024 Proteomic prediction of common and rare diseases. https://www.nature.com/articles/s41591-024-03142-z . NatureMedicine volume 30,  pages2489–2498 (2024)

·       Watanabe K, Wilmanski T, Diener C, et al. Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention.https://www.nature.com/articles/s41591-023-02248-0

·       Petrera A, von Toerne C, Behlr J, et al. Multiplatform Approach for Plasma Proteomics: Complementarity of Olink Proximity Extension Assay Technology to Mass Spectrometry-Based Protein Profiling. (2020) Journal of Proteome Research, 

https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.0c00641

·       Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens. 

Kardell O, von Toerne C, Merl-Pham J, König AC, Blindert M, Barth TK, Mergner J, Ludwig C, Tüshaus J, Eckert S, Müller SA, Breimann S, Giesbertz P, Bernhardt AM, Schweizer L, Albrecht V, Teupser D, Imhof A, Kuster B, Lichtenthaler SF, Mann M, Cox J, Hauck SM. J Proteome Res. 2024 Jan 5;23(1):117-129. doi: 10.1021/acs.jproteome.3c00473. Epub 2023 Nov 28. PMID: 38015820 

https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00473

·       Wei, S., Shen, R., Lu, X. et al. Integrative multi-omics investigation of sleep apnea: gut microbiome metabolomics, proteomics and phenome-wide association study. Nutr Metab (Lond) 22, 57 (2025). https://doi.org/10.1186/s12986-025-00925-0

·       Liu, L., Li, M., Qin, Y. et al. Childhood obesity and insulin resistance is correlated with gut microbiome serum protein: an integrated metagenomic and proteomic analysis. Sci Rep 15, 21436 (2025). https://doi.org/10.1038/s41598-025-07357-z

·       Zhang, Xiaotao et al.Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial. eBioMedicine, Volume 98, 104873 (2023.).  10.1016/j.ebiom.2023.104873

·      &nb...

Welcome to the Olink® Proteomics in Proximity podcast! 
 

Below are some useful resources mentioned in this episode: 

Olink® Reveal, accessible NGS-based proteomics for every lab: https://olink.com/products/olink-reveal

Olink tools and software

·       Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/

·       Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ 

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 

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In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink technology called the Proximity Extension Assay (PEA). More information about the assay and how it works can be found here: https://bit.ly/3Rt7YiY 
 

For any questions regarding information Olink Proteomics, please email us ...

Welcome to the Olink® Proteomics in Proximity podcast! 
  

Below are some useful resources mentioned in this episode: 

Olink tools and software

·       Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/

·       Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ 

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 

Press release and news story from UK Biobank:
https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/launch-of-world-s-most-significant-protein-study-set-to-usher-in-new-understanding-for-medicine

https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/dataset-of-thousands-of-proteins-marks-landmark-step-for-research-into-human-health

https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies

News stories:

• Today Programme – Professor Rory Collins live on programme, timestamp 02:36:37   
• Times – ‘Game-changing’ study of blood proteins will help fight disease 
• Independent – World’s largest proteins study ‘invaluable’ for understanding disease – experts 
• Daily Mail – How Alzheimer's could be diagnosed a DECADE earlier following huge study of blood proteins 
• Mirror – New blood test reveals risk of developing different diseases in 'new frontier of science' 
• Science – Seeking disease insights, UK Biobank launches largest study of human proteins
• Technology Networks – UK Biobank Launches Largest Proteomics Study for Disease Research 
• Chemical and Engineering News – Pharma firms team up to study UK proteomics data 

Links to referred episodes: 

 • Evan – Episode 20:
    https://share.transistor.fm/s/f795811e
    https://open.spotify.com/episode/6lv5GA8hZCgDvujlBltS9f?si=36a29e6cfa4b4fae
    https://podcasts.apple.com/us/podcast/how-proteomics-is-shaping-pharma-strategies/id1645900688?i=1000635040581

• Chris – Episode 16:
    https://share.transistor.fm/s/255ad207 
    https://open.spotify.com/episode/0oe0S6zI8cryUtgZTjGlRq?si=8a7b0323b1364b96 
    https://podcasts.apple.com/us/podcast/interview-about-the-uk-biobank-with-dr-christopher-whelan/id1645900688?i=1000622521524 

Subscribe to the podcast on your favorite player or app:

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Google Podcasts: https://podcasts.google.com/feed/aHR0... 
 
 

Amazon Music:

Welcome to the Olink® Proteomics in Proximity podcast! 

Below are some useful resources mentioned in this episode: 

Olink tools and software

Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/

Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ 

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 

Research articles

The support of human genetic evidence for approved drug indications

Matthew R Nelson et al,  Nature Genetics 2015

https://www.nature.com/articles/ng.3314

Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations

M. Austin Argentieri et al,  Nature Medicine 2024

https://www.nature.com/articles/s41591-024-03164-7

Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems

Ludger J.E. Goeminne et al, Cell Metabolism 2024, in press

https://www.sciencedirect.com/science/article/abs/pii/S1550413124004017?via%3Dihub

Plasma proteomic associations with genetics and health in the UK Biobank

Benjamin B. Sun et, Nature 2023

https://www.nature.com/articles/s41586-023-06592-6

Rare variant associations with plasma protein levels in the UK Biobank

Ryan S. Dhindsa; Nature 2023

https://www.nature.com/articles/s41586-023-06547-x

Disease prediction with multi-omics and biomarkers empowers case–control genetic discoveries in the UK Biobank

Manik Garg, Nature Genetics, 2024

https://www.nature.com/articles/s41588-024-01898-1

China Kadoorie Biobank: https://www.ckbiobank.org/publications

Publications: https://www.ckbiobank.org/publications

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Podcast Addict:

Welcome to the Olink® Proteomics in Proximity podcast! 

Below are some useful resources mentioned in this episode: 

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 

UKB-PPP online resources developed by Nick Lehner and Maria Wörheide

https://metabolomips.org/ukbbpgwas/

Metabolomics and Proteomics Core in Munich:

https://www.helmholtz-munich.de/en/core-facility-overview/metabolomics-and-proteomics

https://www.helmholtz-munich.de/core-facilities

[email protected] 

ClinspectM (https://clinspect-m.mscoresys.de/) consortium in the Munich area dedicated to move proteomics forward to clinical application

More joint initiatives towards Germany-wide benchmarking and standardized processes are in the making, follow the news on https://www.mscoresys.de/

Research articles

Sun, B.B., Chiou, J., Traylor, M. et al.  Plasma proteomic associations with genetics and health in the UK Biobank. 2023 Nature, DOI: 10.1038/s41586-023-06592-6 

https://www.nature.com/articles/s41586-023-06592-6

Petrera A, von Toerne C, Behlr J, et al. Multiplatform Approach for Plasma Proteomics: Complementarity of Olink Proximity Extension Assay Technology to Mass Spectrometry-Based Protein Profiling. (2020) Journal of Proteome Research

https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.0c00641

Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens. 

Kardell O, von Toerne C, Merl-Pham J, König AC, Blindert M, Barth TK, Mergner J, Ludwig C, Tüshaus J, Eckert S, Müller SA, Breimann S, Giesbertz P, Bernhardt AM, Schweizer L, Albrecht V, Teupser D, Imhof A, Kuster B, Lichtenthaler SF, Mann M, Cox J, Hauck SM. J Proteome Res. 2024 Jan 5;23(1):117-129. doi: 10.1021/acs.jproteome.3c00473. Epub 2023 Nov 28. PMID: 38015820 

https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00473

Olink tools and software

Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/

Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ 

Subscribe to the podcast on your favorite player or app:

Apple Podcasts: https://apple.co/3T0YbSm 
 

Spotify Podcasts: https://open.spotify.com/show/2sZ2wxO... 
 

Google Podcasts: https://podcasts.google.com/feed/aHR0... 
 

Amazon Music:

Welcome to the Olink® Proteomics in Proximity podcast!

Below are some useful resources mentioned in this episode:

Olink tools and software
• Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/
• Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies

Research articles
• Dhindsa, R.S., Burren, O.S., Sun, B.B. et al. Rare variant associations with plasma protein levels in the UK Biobank. 2023 Nature, DOI: 10.1038/s41586-023-06547-x
https://www.nature.com/articles/s41586-023-06547-x
• Sun, B.B., Chiou, J., Traylor, M. et al.  Plasma proteomic associations with genetics and health in the UK Biobank. 2023 Nature, DOI: 10.1038/s41586-023-06592-6
https://www.nature.com/articles/s41586-023-06592-6
• Ticau S, Sridharan G, Tsour S, et al. Neurofilament Light Chain as a Biomarker of Hereditary Transthyretin-Mediated Amyloidosis 2021 Neurology, DOI: 10.1212/WNL.0000000000011090
https://n.neurology.org/content/96/3/e412.long
• Zannad F, Ferreira JP, Butler J, et al.  Effect of Empagliflozin on Circulating Proteomics in Heart Failure: Mechanistic Insights from the EMPEROR Program. 2022 European Heart Journal, DOI: 10.1093/eurheartj/ehac495               
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac495/6676779
• Eldjarn GH, et al. Large-scale plasma proteomics comparisons through genetics and disease associations. Nature. 2023 Oct;622(7982):348-358. doi: 10.1038/s41586-023-06563-x
https://www.nature.com/articles/s41586-023-06563-x#Sec44
• [PREPRINT] Carrasco-Zanini et al 2023 Proteomic prediction of common and rare diseases MedRxiv https://www.medrxiv.org/content/10.1101/2023.07.18.23292811v1
• Michaëlsson E, Lund LH, Hage C, et al. Myeloperoxidase Inhibition Reverses Biomarker Profiles Associated With Clinical Outcomes in HFpEF. 2023 JACC. Heart Failure, DOI: 10.1016/j.jchf.2023.03.002
https://www.sciencedirect.com/science/article/pii/S2213177923001257
• Girerd N, Levy D, Duarte K, et al.  Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. 2023 Circulation Heart Failure, DOI: 10.1161/CIRCHEARTFAILURE.122.009694
https://www.ahajournals.org/doi/abs/10.1161/CIRCHEARTFAILURE.122.009694

Subscribe to the podcast on your favorite player or app:
Apple Podcasts: https://apple.co/3T0YbSm
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Podcast Addict: https://podcastaddict.com/podcast/409...
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Player FM: https://player.fm/series/series-3396598

In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink technology called the Proximity Extension Assay (PEA). More information about the assay and how it works can be found here: https://bit.ly/3Rt7YiY

For any questions regarding information about Olink Proteomics, please email us at [email protected] or visit our website: https://www.olink.com/

Interested in a specific podcast topic or guest? Reach out to us at [email protected]

WHAT IS PROTEOMICS IN PROXIMITY?
Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Cindy Lawley and Sarantis Chlamydas.

Welcome to the Olink® Proteomics in Proximity podcast! 
 
 

Below are some useful resources from this episode: 

Published study of primary focus

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C. Proteogenomic links to human metabolic diseases. Nat Metab. 2023 Mar;5(3):516-528. doi: 10.1038/s42255-023-00753-7. Epub 2023 Feb 23. Erratum in: Nat Metab. 2023 Mar 19;: PMID: 36823471; PMCID: PMC7614946. https://pubmed.ncbi.nlm.nih.gov/36823471/

Laboratory, first author, and corresponding author of the study

·         Public Health University Research Institute (PHURI), a multidisciplinary research center to drive personalized healthcare: https://www.qmul.ac.uk/phuri/about/

·         Mine Koprulu (first author), PhD student, University of Cambridge: https://www.linkedin.com/in/mine-koprulu-497659b9/  

·         Dr. Claudia Langenberg (corresponding author); Director of PHURI, Queen Mary, University of London; Professor of Computational Medicine, Berlin Institute of Health at Charité: https://www.qmul.ac.uk/phuri/our-people/professor-claudia-langenberg/ 

Olink tools and software

·         Olink® Explore 3072, the platform that measured proteins in this study with a next-generation sequencing (NGS) readout: https://olink.com/products-services/explore/

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 

Genotype-Tissue Expression (GTEx) project, a biobank and open-access database to study tissue-specific gene expression and regulation: https://www.gtexportal.org/home/

European Prospective Investigation into Cancer (EPIC)-Norfolk study, a prospective cohort of middle-aged individuals from Eastern England: https://www.epic-norfolk.org.uk/ 

Genome Aggregation Database (gnomAD), the largest publicly available collection of population variation from harmonized exome and genome sequencing data: https://gnomad.broadinstitute.org/ 

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Deezer:

Welcome to the Olink® Proteomics in Proximity podcast! 
 

Below are some useful resources from this episode: 

Published study of primary focus

Álvez MB, Edfors F, von Feilitzen K, Zwahlen M, Mardinoglu A, Edqvist PH, Sjöblom T, Lundin E, Rameika N, Enblad G, Lindman H, Höglund M, Hesselager G, Stålberg K, Enblad M, Simonson OE, Häggman M, Axelsson T, Åberg M, Nordlund J, Zhong W, Karlsson M, Gyllensten U, Ponten F, Fagerberg L, Uhlén M. Next generation pan-cancer blood proteome profiling using proximity extension assay. Nat Commun. 2023 Jul 18;14(1):4308. doi: 10.1038/s41467-023-39765-y. PMID: 37463882; PMCID: PMC10354027. https://pubmed.ncbi.nlm.nih.gov/37463882/ 

Laboratory, first author, and corresponding author of the study

·         SciLifeLab, a collaborative resource for life scientists located in Sweden: https://www.scilifelab.se/

·         María Bueno Álvez (first author), PhD student, Science for Life Laboratory (SciLifeLab): https://www.linkedin.com/in/mar%C3%ADa-bueno-%C3%A1lvez-33395b192/ 

·         Dr. Mathias Uhlén (corresponding author), Professor of Microbiology, Royal Institute of Technology (KTH), Leader of the Human Protein Atlas, Founding director of the Science for Life Laboratory (SciLifeLab): https://www.kth.se/pro/sysbio/uhlen-group/researchers/mathias-uhlen-1.67763 

Olink tools and software

·         Olink® Explore 1536, the platform that measured proteins in this study with a next-generation sequencing (NGS) readout: https://olink.com/products-services/explore/

·         Olink® Explore HT, Olink’s newest solution for high-throughput biomarker discovery that measures 5300+ proteins simultaneously with minimal sample consumption: https://olink.com/products-services/exploreht/ 

·         Olink® Insight, an open-access resource to accelerate protein biomarker discovery: https://insight.olink.com/

UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date

·         Published article: Styrkarsdottir U, Lund SH, Thorleifsson G, Saevarsdottir S, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K. Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource. Arthritis Rheumatol. 2023 Apr;75(4):544-552. doi: 10.1002/art.42376. Epub 2022 Dec 28. PMID: 36239377. https://pubmed.ncbi.nlm.nih.gov/36239377/ 

·         UKB-PPP website: https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 

Analysis of UK Biobank proteomics data from cancer patients, with co-authors including Ruth C. Travis, Karl Smith-Byrne, and Joshua R. Atkins

Preprint article: Papier K, Atkins JR, Tong TYN, Gaitskell K, Desai T, Ogamba CF, Parsaeian M, Reeves GK, Mills IG, Key TJ, Smith-Byrne K, Travis RC. Identifying proteomic risk factors for cancer using prospective and exome analyses: 1,463 circulating proteins and risk of 19 cancers in the UK Biobank. medRxiv 2023.07.28.23293330; doi: https://doi.org/10.1101/2023.07.28.23293330. https://www.medrxiv.org/content/10.1101/2023.07.28.23293330v1 

U-CAN Biobank, a prospective biobank of cancer patient biomaterial in Sweden

Glimelius B, Melin B, Enblad G, Alafuzoff I, Beskow A, Ahlström H, Bill-Axelson A, Birgisson H, Björ O, Edqvist PH, Hansson T, Helleday T, Hellman P, Henriksson K, Hesselager G, Hultdin M, Häggman M, Höglund M, Jonsson H, Larsson C, Lindman H, Ljuslinder I, Mindus S, Nygren P, Pontén F, Riklund K, Rosenquist R, Sandin F, Schwenk JM, Stenling R, Stålberg K, Stålberg P, Sundström C, Thellenberg Karlsson C, Westermark B, Bergh A, Claesson-Welsh L, Palmqvist R, Sjöblom T. U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden. Acta Oncol. 2018 Feb;57(2):187-194. doi: 10.1080/0284186X.2017.1337926. Epub 2017 Jun 20. PMID: 28631533. https://pubmed.ncbi.nlm.nih.gov/28631533/ 

Galleri GRAIL test, a blood-based test that detects a biosignature shared by over 50 cancer types: https://grail.com/galleri-test/ 

Genotype-Tissue Expression (GTEx) project, a biobank and open-access database to study tissue-specific gene expression and regulation: https://www.gtexportal.org/home/

Human Protein Atlas (HPA), a Swedish-based program with the aim to map all human proteins using an integration of various omics technologies and provide these data freely available to the scientific community: https://www.proteinatlas.org/ 

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