Psychcast

Charles Raison, MD, returns to the Psychcast this week to give a Masterclass lecture on the bidirectional relationship between inflammation and depression. There are links to relevant research below.

Dr. Raison discusses incorporating the science of inflammation into the pharmacologic treatment of depression. He addresses research suggesting that while depression as a whole isn't an inflammatory condition, inflammation may be a depressive subtype. He also covered how inflammation might affect treatment.

You can listen to Dr. Raison's take-home messages by skipping to (19:45).

CHARLES RASION, M.D.

Dr. Raison is Mary Sue and Mike Shannon Chair for Healthy Minds, Children, & Families and Professor of Human Development and Family Studies at the School of Human Ecology as well as Professor in the Department of Psychiatry at the University of Wisconsin-Madison School of Medicine and Public Health.

Dr. Raison previously appeared on Psychast in a two-part lecture on ketamine. In episode 14, Dr. Raison talked on ketamine and PTSD and in episode 15, he talked about ketamine and depression. You can find those episodes by clicking the links below:

Psychcast Episode 14: Charles Raison, MD, Ketamine & PTSD.

Psychcast Episode 15: Charles Raison, MD, Ketamine & depression.

Relevant Research:

Use these links to find more on this Masterclass.

Rong, Carola, et al. Predictors of Response to Ketamine in Treatment Resistant Major Depressive Disorder and Bipolar Disorder. Int J Environ Res Public Health. 2018 Apr 17:15(4): doi: 10.3390/ijerph15040771. https://www.ncbi.nlm.nih.gov/pubmed/29673146

Savitz, JB et al. Treatment of Bipolar Depression With Minocycline and/or aspirin: an adaptive, 2x2 double-blind, randomized, placebo-controlled, phase II-A clinical trial. Transl Psychiatry. 2018 Jan 24;8(1):27. doi: 10.1038/s41398-017-0073-7. https://www.ncbi.nlm.nih.gov/pubmed/29362444

Raison, et al. A Randomized Controlled Trial of the Tumor Necrosis Factor-alpha Antagonist Infliximab in Treatment Resistant Depression: Role of Baseline Inflammatory Biomarkers. JAMA Psychiatry. 2013 Jan;70(1):31-41. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015348/

Miller AH, Raison CL. Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders?: Where the Rubber Meets the Road. JAMA Psychiatry. 2015 Jun; 72(6): 527–528. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542670/

Adzic M, et al. Therapeutic Strategies for Treatment of Inflammation-related Depression. Curr Neuropharmacol. 2018 Jan 30;16(2):176-209. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883379/

Episode 52: Tardive dyskinesia masterclass II

Leslie Citrome, MD, MPH, returns to the MDedge Psychcast to lecture on Tardive Dyskinesia. In episode 52, where we caught up with Dr. Citrome at the Psychopharmacology Update meeting in Cincinnati, he discusses how to evaluate treatments for TD within the context of P values and effect sizes.

Dr. Citrome joined Psychcast host Lorenzo Norris, MD, in the 13th edition of the Psychcast to talk about management of TD. In episode 13, Dr. Citrome said that you can start screening your patients in the waiting room as well as when they walk to the exam room.

He and Dr. Norris also discussed movement conditions and the role antipsychotics might play in patients with TD. You can listen to the conversation between Dr. Norris and Dr. Citrome from July of 2018 by clicking here.

TD has been a recent topic of interest at the Psychcast. In the 45th episode Johnathan Meyer, MD, noted that TD has been the bane of the psychiatrist's existence for the better part of a half-century. You can listen to our tardive dyskinesia Masterclass I by clicking here.

We would love to hear from you. Contact the show if you have feedback, questions, or ideas for segments, guests or topics. Email us at [email protected] or Tweet at us @MDedgePsych.

Contact us: [email protected]

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In this In this masterclass episode, Stephen Levine, MD, stops by to talk about how a person's sexuality flows throughout their lives.

And later, Dr. RK discusses bipolar in part I of her new series.

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Twitter: @mdedgepsych

Masterclass Lecture: What's New in Alzheimer's Disease.

Lecturer: George T. Grossberg, MD.

He is the Samuel W. Fordyce professor and Director of Geriatric Psychiatry at St. Louis University School of Medicine.

You can read more from Dr. Grossberg including video and writing, by clicking here.

Dr. RK:

Dr. RK's topic this week is the MDQ and how she uses in her practice. Learn more about the MDQ by clicking here.

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Twitter: @mdedgepsych

In this episode, Nicolas Badre, MD, talks with Lorenzo Norris, MD, about ways to approach reducing dosages or discontinuing medications that aren't beneficial. And Renee Kohanski, MD, ponders the privilege of being part of patients' gifted moments.

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Twitter: @mdedgepsych

In this episode, Marlene Freeman, MD, discusses the latest studies on the risks of treating, and not treating, women with bipolar disorder during pregnancy. And Renee Kohanski, MD, returns with part two of her feature on eating her own words.

Contact us: [email protected]Twitter: @mdedgepsych

Richard Balon, MD, is professor of clinical psychiatry and anesthesiology and associate chair of education at Wayne State University in Detroit.

In this masterclass episode of psychcast, he lectures on the recent increase in the price of drugs.

Contact us: [email protected]

In this episode, Igor Galynker, MD, stops by to talk about suicide with Lorenzo Norris, MD. One major topic of conversation centers around the suicide-specific diagnosis. And later, Renee Kohanski, MD, talks about the importance of communication. You can listen to Dr. Galynker's first appearance on the Psychcast here (http://bit.ly/2LGiRwn).

Contact us: [email protected]

Twitter: @mdedgepsych

Contact us: [email protected]

Twitter: @MDedgePsych

Johnathan Meyer, MD, notes that TD has been the bane of the psychiatrist's existence for the better part of a half century. In this Mastercalss edition, Dr. Meyer talks about this disease and analyzes where the field is today.