The field of neuroscience has been collecting more and more data, and developing increasingly advanced technological tools in its race to understand how the brain works. But can those data and tools ever yield true understanding? This episode features neuroscientist and computer scientist Eric Jonas, discussing his provocative paper titled "Could a Neuroscientist Understand a Microprocessor?" in which he applied state-of-the-art neuroscience tools, like lesion analysis, to a computer chip. By applying neuroscience's tools to a system that humans fully understand (because we built it from scratch), he was able to reveal how surprisingly uninformative those tools actually are. Julia and Eric also discuss the related question: what kind of tools *would* we need to really understand the brain?