Host: Brian P. McDonough, MD, FAAFP

Guest: Michael Lim, MD

Despite significant progress in the treatment for glioblastoma multiforme, or GBM, patient outcomes have failed to see a drastic improvement. Recently, immune checkpoint inhibitors have shown promise in treating patients with GBM in cases where conventional treatment options have failed. The rapid progression of GBM necessitates timely and well-informed decisions made on the part of the clinician. This activity will provide the participant with up-to-date evidence regarding the immune system of patients with GBM as well as ongoing and recent clinical data regarding immune checkpoint inhibitors as treatment options. Selected References Andtbacka RH et al. J Clin Oncol. 2015;33:2780-2788. Robert C et al. Lancet. 2014;384:1109-1117. Fecci PE et al. Clin Cancer Res. 2007;13:2158-2167. Garber ST et al. Neuro-Oncology. 2016;18:1357-1366. Hodi FS et al. N Engl J Med. 2010;363:711-723. Jiang et al. Nat Med. 2016;22:851-860. Kantoff. N Engl J Med. 2010;363:411. Kim et al. Clin Cancer Res. 2017;23:124-136. Pardoll DM. Nat Rev Cancer. 2012;12:252-264. Weber J. Semin Oncol. 2010;37:430-439. Zaretsky JM et al. N Engl J Med. 2016;375:819-829. Zeng J et al. Int J Radiat Oncol Biol Phys. 2013;86:343-349.

Guest: Warner K. Huh, MD

While the prevalence of cervical cancer in the population has decreased over the years, there are still 12,820 new cases and 4,210 deaths estimated in 2017; however, despite this progress, there remains marked uncertainty among healthcare providers regarding the optimal screening strategy for cervical cancer. While both primary high-risk HPV testing and cotesting approaches are known to be superior to cytology-alone, current evidence suggests that many patients as well as providers continue to favor cytology-based testing annually. Healthcare providers thus face challenges in integrating cotesting and primary high-risk HPV testing in clinical practice, or choosing one over the other for individual patients. The case presented in this CME activity addresses some of the issues faced by clinicians when selecting cervical cancer screening strategies for their patients.

Guest: J. Kevin Harrison, MD

CME Information FacultyJ. Kevin Harrison, MDProfessor of MedicineInterventional Director, Duke Center for Structural Heart DiseaseDuke University Health SystemDurham, NC Activity PlannersJulie Blum, PhDClinical Content ManagerMed-IQBaltimore, MD Rebecca L. Julian, MS, ELSSenior Managing EditorMed-IQBaltimore, MD Amy SisonDirector of Continuing Medical EducationMed-IQBaltimore, MD WriterAnne Jacobson, MPHPort St. John, FL Activity OverviewThis activity discusses valve replacement strategies, including guideline recommendations, risks, and benefits of such strategies in cardiac patients. Learning ObjectivesUpon completion, participants should be able to: Describe the differences in general criteria for TAVR and SAVR Understand the risks and benefits of available devices and how using these devices compares with standard medical therapy Target AudienceThis activity is intended for cardiologists. Statement of NeedValvular aortic stenosis (AS) is a progressive disease caused by calcification of the aortic valve, with underlying pathophysiologic processes similar to those of atherosclerosis. The prevalence of moderate or severe AS increases with advancing age and currently affects approximately 3% of individuals aged 75 years or older. Although asymptomatic AS does not increase the risk of death, patient prognosis deteriorates substantially once the disease becomes symptomatic. In this activity, recent clinical trial evidence and updated guidelines are presented to ensure that clinicians are making proper treatment decisions for their ...

Host: John J. Russell, MD

Guest: Emma Guttman-Yassky, MD, PhD

Building upon recent breakthroughs in our understanding of the pathologic mechanisms driving atopic dermatitis (AD), the existing pharmacopoeia is preparing for possible approval by the United States Food and Drug Administration of novel therapies that narrowly target immune dysregulation in moderate-to-severe disease. As a result, clinicians need to be knowledgeable about how these emerging agents modulate immune response in AD, as well as understand the clinical trial data regarding their use in patients with moderate-to-severe disease. Thus, clinicians who treat patients with this condition can be prepared to incorporate emerging therapies into treatment plans for appropriate patients as they become available. As a value added-resource, a specialized toolkit will also be included as a supplement to the webcast. The toolkit will provide for clinicians the latest treatment guidelines and updated reference guide. In addition, the toolkit will provide helpful information and resources for families and caregivers.

Host: Jennifer Caudle, DO

Guest: Allan Gibofsky, MD, JD, MACR, FACP, FCLM

In this interview, Dr. Gibofsky will be assessing disease activity and targeted treatment by applying the 2015 ACR guidelines for treating patients with rheumatoid arthritis.

CME credits: 0.25

Valid until: 05-04-2020

Claim your CME credit at https://reachmd.com/programs/cme/burdensome-vaginal-infections-best-diagnostic-practices-driving-better-patient-outcomes/8414/

Vaginitis is one of the most common infections affecting women’s health. This interview will discuss diagnostic and treatment approaches to the patient presenting with vaginitis.

Guest: Manesh R. Patel, MD, FACC, FAHA, FSCAI

Guest: Peter K. Smith, MD

CME Information FacultyManesh R. Patel, MD, FACC, FAHA, FSCAIAssociate Professor of MedicineChief, Division of CardiologyDuke University Health System and Duke Clinical Research InstituteDurham, NC Peter K. Smith, MDProfessor of SurgeryAssociate Professor of Biomedical EngineeringInterim Chief, Cardiac Surgery, Durham VA Medical CenterDivision Chief, Thoracic and Cardiovascular SurgeryCo-Director, Duke Heart Center Duke University Health System Durham, NC Activity PlannersJulie Blum, PhDClinical Content ManagerMed-IQBaltimore, MD Laura EspinozaAssociate Managing EditorMed-IQ Baltimore, MD Amy SisonDirector of Continuing Medical EducationMed-IQBaltimore, MD WriterKatherine KahnSouthampton, MA Activity OverviewThis CME-certified online publication examines the risks and benefits of using coronary artery bypass graft surgery or percutaneous coronary intervention as a revascularization strategy in patients with coronary artery disease. It presents recent clinical evidence and guideline recommendations to help clinicians make appropriate treatment decisions and improve survival in their cardiac patients. Learning ObjectiveUpon completion, participants should be able to: Incorporate individual risk information and other patient-specific factors into evidence-based revascularization decisions for patients with CAD Target AudienceThis activity is intended for cardiologists. Statement of NeedBoth coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI) have been established as effective methods for revascularization in patients with coronary artery disease. In many instances, however, the optimal choice of treatment—CABG or ...

Guest: Anand B. Joshi, MD, MHA

CME Information FacultyAnand B. Joshi, MD, MHAAssistant ProfessorDuke University Medical CenterDepartment of Orthopaedic SurgeryDurham, NC Activity PlannersAllison Gardner, PhD Vice President, Educational Strategy and ContentMed-IQBaltimore, MD Laura RaffertyAssociate Managing EditorMed-IQBaltimore, MD Amy SisonDirector of Continuing Medical EducationMed-IQBaltimore, MD WriterMark R. Vogel, MASan Francisco, CA Activity OverviewThis CME-certified online publication focuses on the initial evaluation and evidence-based management of acute low back pain. It explores approaches to diagnose acute low back pain, assess patients’ prognosis based on established psychosocial indicators for prolonged pain, and identify when diagnostic imaging is warranted. Furthermore, the publication presents available clinical evidence for various pharmacologic and nonpharmacologic treatment strategies to address acute low back pain, as well as provides guidance on when to engage specialists to address pain that is not resolved by noninvasive means. Strategies for the Noninvasive Management of Acute Low Back PainThe American College of Physicians (ACP) recently released updated guidelines for the noninvasive treatment of nonradicular subacute, acute, and chronic low back pain in primary care. For acute and subacute low back pain, the ACP made the following strong recommendation: Given that most patients with acute or subacute low back pain improve over time regardless of treatment, clinicians and patients should select ...

Guest: Sanziana Roman, MD, FACS

CME Information FacultySanziana Roman, MD, FACSProfessor of SurgerySection of Endocrine SurgeryDepartment of SurgeryAssociate Chief, Division of Advanced Oncologic and GI SurgeryDuke University Medical CenterDurham, NC Activity PlannersChristie Avraamides, PhDClinical Content ManagerMed-IQBaltimore, MD Rebecca L. Julian, MS, ELSSenior Managing EditorMed-IQBaltimore, MD Amy SisonDirector of Continuing Medical EducationMed-IQBaltimore, MD WriterKatherine A. KahnHuntington, MA Activity OverviewThis online CME publication reviews proper evaluation and diagnostic strategies in patients presenting with potentially malignant thyroid nodules. Recommended approaches to treatment, postsurgical management, and follow-up care of patients with thyroid cancer are also discussed. Learning ObjectivesUpon completion, participants should be able to: Explain the diagnostic strategies and proper evaluation in patients presenting with thyroid nodules or thyroid cancer Discuss the recent advances in surgical and targeted treatment approaches for thyroid cancer Target AudienceThis activity is intended for physicians, nurse practitioners, physician assistants, nurses, and pharmacists. Statement of NeedThyroid nodules are a common finding in clinical practice. Although the majority of nodules are benign, determining whether a nodule is benign or malignant can be challenging. Clinicians must understand the appropriate steps in evaluating nodules, know when to refer, and be up-to-date on treatment approaches available to patients with thyroid cancer. This publication will help clinicians navigate the challenges ...

Guest: Matthew J. Ellis, MD

Guest: Scott L. Sanoff, MD, MPH

CME Information FacultyMatthew J. Ellis, MDMedical Director of Kidney & Pancreas TransplantationAssistant Professor of MedicineDivision of NephrologyAssistant Professor of SurgeryDivision of Abdominal TransplantDuke University Health SystemDurham, NC Scott L. Sanoff, MD, MPHAssistant Professor of MedicineDivision of NephrologyDuke University Health SystemDurham, NC Activity PlannersIwona Misiuta, PhD, MHAClinical Content ManagerMed-IQBaltimore, MD Amy SisonDirector of Continuing Medical EducationMed-IQBaltimore, MD Activity OverviewIn this engaging discussion-based, CME-certified Webcast, two expert transplant nephrologists from Duke University Health System explain the updates to the kidney allocation system and discuss how these changes will affect patient care, referring clinicians, and transplant centers. Learning ObjectivesUpon completion, participants should be able to: Explain the rationale and objectives for the new kidney allocation scheme Understand how the revised kidney allocation policy addresses outcome objectives including maximizing transplant outcomes and reducing waiting times for historically disadvantaged patient populations Anticipate the practical impact of the new kidney allocation scheme on patients and referring clinicians Discuss transplant centers’ preparations for the new allocation system Target AudienceThe primary target audience for this activity is community nephrologists, transplant nephrologists, nephrology fellows, transplant coordinators, primary care physicians, and other members of the kidney transplant team. Statement of NeedMore than 96,000 people are currently listed for kidney transplantation ...