Unlike morphine and heroin, methadone and its metabolites are generally excreted partially in feces and urine, while they can also be excreted primarily by the hepatobiliary fecal pathway in the presence of renal disease.

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Adults are initially prescribed 20 to 30 milligrams per day in a single dose. It is advised against taking more than the prescribed dose within 24 hours.

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This implies that you have more than a specific amount of it in your body. If the test you took has a cutoff below the amount of opium in poppy seeds, you may produce a positive result. Since the morphine present in poppy seeds generates positive results, it will not appear as methadone on the test. Doxylamine, found in Unisom and other over-the-counter sleep aids, may also cause a false positive on drug tests for methadone

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Excessive sweating induced by methadone use is an adverse effect of the drug that reportedly affects around 45 percent of those prescribed methadone. 

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Alcohol and other narcotic drugs should be avoided while taking methadone. Smoking, eating grapefruit, or drinking grapefruit juice can also decrease the effectiveness of methadone. 

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Your body tends to absorb methadone in about 15 minutes, even if you don't experience the effects for hours. Thus, if you do throw up the taken dose, ensure not to take more methadone. A large amount could already be present in the body, and taking more may result in an overdose. 

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Research had shown that escitalopram, reboxetine, and venlafaxine are generally safe to be administered together with methadone when indicated. However, fluvoxamine, clomipramine, and desipramine substantially amplify methadone-induced effects and should be avoided due to the risk of opiate overdose.

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If you face anxiety while taking methadone, benzodiazepine medications such as Alprazolam, Diazepam, Clonazepam, Lorazepam, Chlordiazepoxide, and Oxazepam can help alleviate or reduce such symptoms.

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The drugs that interact moderately with methadone contains some types of pain medications such as nalbuphine, pentazocine, and butorphanol, naltrexone, MAO inhibitors such as isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine.

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Methadone is a central nervous system depressant. 

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