It is estimated that 3 to 5% of all couples desiring pregnancy will suffer recurrent pregnancy loss (RPL). What are our current understandings of this unfortunate condition, and how can patients be treated to support successful future pregnancies? Host Dr. Patrice Basanta-Henry discusses the many facets of this clinical issue with Dr Kenan Omurtag, Assistant Professor of the Division of Reproductive Endocrinology and Infertility at Washington University School of Medicine in St Louis, Missouri.