Pulmonary hypertension (PH) is a chronic disease associated with significant morbidity and mortality, responsible for approximately 15,000 deaths per year in United States.

The deleterious cardiac effects associated with PH (e.g. Right Ventricular disease) render this population particularly susceptible to decompensation. Hypoxemia, acidosis and hypercapnia are not well tolerated in PH and will acutely increase pulmonary artery pressures, leading to hemodynamic collapse.

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