RxUnedited

In this episode, we discuss the updates from the recent Infectious Diseases Society of America (IDSA) guidelines for community acquired pneumonia (CAP). Thank you for listening!

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

We welcome out friend Ethan on the show to discuss his research project. In addition, we share our opinions on common medication allergies encountered and our process for approaching them.

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

Back from our small break and we're changing up the topics! In this episode, we review the current guidelines from the American Diabetes Association (ADA) for management of DKA.

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

*Kitabchi AE, Umpierrez GE, Miles JM, et al. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009;32(7). 1335-1343.

This time, we review the current options for emergent reversal of DOACs (direct oral anticoagulants) for a major, life threatening bleed. Plus, we discuss some recent literature published regarding use of PCCs (pro-thrombin complex concentrate) and andexanet alfa. In summary, emergent reversal of DOACs in major bleeding is clear as mud.

*Connolly SJ, Crowther M, Eikelboom JW, et al. Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors. N Engl J Med. 2019;380:1326-35.

*Peled H, Dau NQ, Lau H. Key points to consider when evaluating Andexxa for formulary addition. Neurocrit Care. 2019. https://doi.org/10.1007/s12028-019-00866-6.

*Piran S, Khatib R, Schulman S, et al. Management of direct factor Xa inhibitor-related major bleeding with prothrombin complex concentrate: a meta-analysis. Blood Advances. 2019;3(2):158-167.

*Kaide CG, Gulseth MP. Current strategies for the management of bleeding associated with direct oral anticoagulants and a review of investigational reversal agents. J Emerg Med. 2019. https://doi.org/10.1016/j.jemermed.2019.10.011.

*Schulman S, Kearon C and. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non‐surgical patients. Journal of Thrombosis and Haemostasis, 3: 692-694. doi:10.1111/j.1538-7836.2005.01204.x

*Khorsand N, Majeed A, Sarode R, et al. Assessment of effectiveness of major bleeding management: proposed definitions for effective hemostasis: communication from the SSC of the ISTH. J Thromb Haemost 2016; 14: 211– 4.

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

We check out some interesting studies and reviews on anticoagulation that were published recently. Citations are below for those interested in checking them out personally. P.S. please excuse my hiccup with warfarin :( you will see. Thanks for listening!

*Coons J, Albert L, Bejjani A, et al. 2020. Effectiveness and Safety of Direct Oral Anticoagulants versus Warfarin in Obese Patients with Acute Venous Thromboembolism. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 40(3), pp.204-210.

*Khan SU, Osman M, Khan MU, et al. Dual versus triple therapy for atrial fibrillation after percutaneous coronary intervention. Ann Intern Med. Doi:10.7326/M19-3763.

*Kido K, Lee J, Hellwig T, et al. 2019. Use of Direct Oral Anticoagulants in Morbidly Obese Patients. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 40(1), pp.72-83.

*Lutsey PL, Norby FL, Ensrud KE, et al. Association of anticoagulant therapy with risk of fracture among patients with atrial fibrillation. JAMA Intern Med. 2020; 180:245-53.

*Ordi-Ros J, Saez-Comet L, Perez-Conesa M, et al. Rivaroxaban versus vitamin K antagonist in antiphospholipid syndrome. Ann Intern Med. 2019;171:685-694.

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

A quick refresher on medications that can be used in hypertensive crises along with their benefits and risks.

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

We welcome our first guests Thinh and Khanhly on the show! Both are practicing RNs in the critical care setting. They came to share with us their knowledge about different types of IV access and use of IV pumps in the hospital setting.

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

We skipped the basics of HFrEF to bring you updates from 2017 heart failure guidelines, PIONEER-HF and DAPA-HF.

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***