Sarcoma Insight Podcast

Liposarcomas are malignant tumors of fatty tissue. They can occur in various parts of the body. They are soft tissue sarcomas with multiple subtypes. In this episode we discuss the presentation, management and treatment of Liposarcomas with our Guest, Dr. Peter Fergusion, Musculoskeletal oncologist and Chairman of the University of Toronto Department of Orthopaedics.

Links & Article(s)

Crago AM, Dickson MA. Liposarcoma: Multimodality Management and Future Targeted Therapies. Surg Oncol Clin N Am. 2016;25(4):761-773. doi:10.1016/j.soc.2016.05.007

Kenneth R Gundle et al. Analysis of Margin Classification Systems for Assessing the Risk of Local Recurrence After Soft Tissue Sarcoma Resection. 2018 Mar 1;36(7):704-709.

Julia D Visgauss et al. Staging and Surveillance of Myxoid Liposarcoma: Follow-up Assessment and the Metastatic Pattern of 169 Patients Suggests Inadequacy of Current Practice Standards. Ann Surg Oncol. 2021 Nov;28(12):7903-7911

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Lipomas are benign tumors of adipose tissue or fat. They are often subcutaneous in nature but vary in size and location. Atypical Lipomatous tumors also known as well differentiated liposarcomas are tumors of fat with low metastatic and malignant potential. Atypical lipomatous tumor and lipomas as part of a spectrum of fatty tumors. Their presentation, management and treatments are reviewed in this episode.

Links

Charifa A, Azmat CE, Badri T. Lipoma Pathology. 2021 Dec 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 29493968.

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

There are multiple team members who all play an important role in providing coordinated multidisciplinary care for the betterment of patients with sarcomas and tumors. A pathologist is a member of the team with a key role to play. Pathologic analysis is key in being able to identify and diagnose tumors as well as evaluate and grade tumors. We have pathologist Dr. Erica Kao join us to further elucidate on the role of the pathologist in this episode.

Rubin BP, Goldblum JR. Pathology of soft tissue sarcoma. J Natl Compr Canc Netw. 2007 Apr;5(4):411-8. doi: 10.6004/jnccn.2007.0036. PMID: 17442232..

Patterson K. The pathologic handling of skeletal tumors. Am J Clin Pathol. 1998 Apr;109(4 Suppl 1):S53-66. PMID: 9533749.

Oliveira AM, Nascimento AG. Grading in soft tissue tumors: principles and problems. Skeletal Radiol. 2001 Oct;30(10):543-59. doi: 10.1007/s002560100408. PMID: 11685477

Sarcomas remains a challenging diagnosis for patients and families. Sometimes a dire diagnosis and at difficult times it can be difficult to see what lies ahead. In this Episode we discuss with Dr. Kurt Weiss, Orthopaedic oncology surgeon and sarcoma survivor. Dr. Weiss is simply amazing and we discuss his journey from diagnosis to present, his passions and experience.

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Dr. Weiss:

@ndbonedoc (Instagram) https://www.instagram.com/ndbonedoc/

Find out more Pittsburgh University's Ortho Dept. https://www.instagram.com/pittortho/

Osteosarcomas are malignant tumors of bone. The treatment of osteosarcomas have continued to evolve to include chemotherapy, limb salvage and more novel methods such as immunotherapy and targeted therapy. In this episode we discuss osteosarcoma with our guest Dr. Chris Collier of Indiana University.

Links & Article(s)

https://www.cancer.org/cancer/osteosarcoma/detection-diagnosis-staging/survival-rates.html

Misaghi A, Goldin A, Awad M, Kulidjian AA. Osteosarcoma: a comprehensive review. SICOT J. 2018;4:12. doi:10.1051/sicotj/2017028

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Osteoblastomas and chondroblastomas are benign tumors without known malignant potential. They can both be associated with pain and discomfort, they can be mimicked by other tumors. In this episode we discuss the presentation, treatment, management as well as the differential diagnosis for osteoblastomas and chondroblastomas

Links

Limaiem F, Byerly DW, Singh R. Osteoblastoma. [Updated 2021 Aug 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK536954/

Wenqian Chen, Lisa M. DiFrancesco; Chondroblastoma: An Update. Arch Pathol Lab Med 1 June 2017; 141 (6): 867–871. doi: https://doi.org/10.5858/arpa.2016-0281-RS

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Osteochondromas and Osteoid Osteomas are benign tumors of bone. Osteochondromas are known for the external growth from the bone and a cartilage cap. Osteoid Osteomas are known for causing pain to the area of the lesion. In this episode we discuss the pathogenesis, typical presentation and treatment of both diagnoses.

Links

Osteochondroma. Lamya W. Alabdullrahman; Doug W. Byerly. https://www.ncbi.nlm.nih.gov/books/NBK544296/

Dookie AL, Joseph RM. Osteoid Osteoma.

https://www.ncbi.nlm.nih.gov/books/NBK537279/

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

July is Sarcoma awareness month!! A diagnosis of sarcoma can have a lasting impact on patients and families. For those who have been diagnosed and their families, there are resources and groups dedicated to educate, support and raise awareness. In this episode we highlight a few of those groups in our celebration of Sarcoma awareness month.

Links

http://www.sarcomastrong.com

https://sarcomaalliance.org

July is Sarcoma awareness month!! A diagnosis of sarcoma can have a lasting impact on patients and families. For those who have been diagnosed and their families, there are resources and groups dedicated to educate, support and raise awareness. In this episode we highlight a few of those groups in our celebration of Sarcoma awareness month.

Links

http://www.sarcomastrong.com

https://sarcomaalliance.org/

Find out More about our Doctors:

Dr. Izuchukwu Ibe: https://www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: https://www.linkedin.com/in/elyse-brinkmann/

We discuss enchondromas with Dr. Alysia Kemp. Enchondromas are benign cartilaginous tumors that occur within bone. Enchondromas can be difficult to differentiate from low grade chondrosarcomas. It is the second most common benign cartilage tumor. They commonly occur in adults and are often incidental findings. They usually do not cause pain, when they do it warrants further examination.

Links

Sarcomadoc.com

Akoh CC, Craig E, Troester AM, Miller BJ. Radiographic Enchondroma Surveillance: Assessing Clinical Outcomes and Costs Effectiveness. Iowa Orthop J. 2019;39(1):185-193.

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Conventional chondrosarcoma is a common sarcoma of bone. It is a common sarcoma and affects adults. It can mimic or arise from benign tumors, and in some cases it is associated with familial or hereditary links. This episode covers the epidemiology, common mode of presentation, diagnosis, treatment options and long term surveillance for chondrosarcoma.

Article(s)

Limaiem F, Davis DD, Sticco KL. Chondrosarcoma. [Updated 2020 Dec 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538132/

Wang Z, Chen G, Chen X, et al. Predictors of the survival of patients with chondrosarcoma of bone and metastatic disease at diagnosis. J Cancer. 2019;10(11):2457-2463. Published 2019 Jun 2. doi:10.7150/jca.30388

Chow WA. Chondrosarcoma: biology, genetics, and epigenetics [version 1; peer review: 2 approved]. F1000Research 2018, 7(F1000 Faculty Rev):1826 (https://doi.org/10.12688/f1000research.15953.1)

Find out More about our Doctors:

Dr. Izuchukwu Ibe: https://www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: https://www.linkedin.com/in/elyse-brinkmann/