Sarcoma Insight Podcast

The rarity and uniqueness of each individuals case make research in orthopaedic oncology and sarcoma challenging. The Musculoskeletal Tumor Registry (MsTR) is taking this on, led by Dr. Benjamin Miller and program manager Atusa Moreno. The MsTr is an orthopaedic oncological diagnosis-based registry developed in partnership with the Musculoskeletal Tumor Society (MSTS). The goal of the registry is to capture data on orthopaedic oncology, specifically bone and soft tissue tumor procedures, in a structured and scalable way. On this episode we discuss sarcoma research and the future of the registry

Links

https://www.aaos.org/registries/registry-program/musculoskeletal-tumor-registry/

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Happy New Year from the Sarcoma Insight Family!

Episode recorded: 11/13/2022

Metastatic bone disease are a big cause of pain, morbidity and mortality for patients. The tumor is able to hijack normal bone metabolism and weaken the bone. In this episode we discuss the mechanisms of metastatic disease, diagnosis, management and treatment with Dr. Cory Couch of the Mayo clinic

Links

Rougraff BT, Kneisl JS, Simon MA. Skeletal metastases of unknown origin. A prospective study of a diagnostic strategy. J Bone Joint Surg Am. 1993 Sep;75(9):1276-81.

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Myxofibrosarcomas are often high grade malignant tumors that can be problematic to treat. They are locally aggressive and associated with a high risk of recurrence. In this episode we discuss the diagnostic and treatment dilemmas as well as the management for patients with myxofibrosarcoma.

Links

Castronovo C, Arrese JE, Quatresooz P, Nikkels AF. Myxofibrosarcoma: a diagnostic pitfall. Rare Tumors. 2013 May 31;5(2):60-1. doi: 10.4081/rt.2013.e15. PMID: 23888215; PMCID: PMC3719110

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Myxomas are benign soft tissue tumors filled with gelatinous material. They can be painful and occur in many different parts of the body. In this episode we discuss the common presentation, treatment, management and follow up after a diagnosis with Myxoma. We also discuss the differential diagnosis for myxoma which includes malignant tumors that should be ruled out when making the diagnosis.

Akshay D. Baheti, Sree Harsha Tirumani Michael H. Rosenthal Stephanie A. Howard Atul B. Shinagare Nikhil H. Ramaiya Jyothi P. Jagannathan. Myxoid Soft-Tissue Neoplasms: Comprehensive Update of the Taxonomy and MRI Features. AJR:204, February 2015

Links

Subramanian S, Kemp AK, Viswanathan VK. Bone Cyst. [Updated 2022 Jan 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539849

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Tune in for the second installment of our series, featuring Sarcoma patients/ survivors and their stories: with Brandi Benson. An Ewing sarcoma survivor, Entrepreneur, veteran, author and much more. We discuss her amazing journey from diagnosis to present. We have Brandi's mother with us for the episode and discuss the role and effect of the Sarcoma diagnosis on members of the family.

https://brandilbenson.com/

Sarcomaalliance.org

sarcomastrong.com

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Synovial Sarcomas are rare malignant tumors of soft tissue. Unlike most soft tissue sarcomas they are more likely to affect younger individuals. This tumor type is unique because of a common chromosomal translocation and mutation. They also have a high predilection of metastasis to lung and to the lymph nodes.

Links & Article(s)

Gazendam AM, Popovic S, Munir S, Parasu N, Wilson D, Ghert M. Synovial Sarcoma: A Clinical Review. Curr Oncol. 2021;28(3):1909-1920. Published 2021 May 19. doi:10.3390/curroncol28030177

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

In this special episode we discussed topics and questions from our listeners with Musculoskeletal oncologists. The setting was the Toronto Musculoskeletal Oncology Conference. Topics include;

Why have the medical treatments for patients with sarcoma remain unchanged for years

The effect of mental health toll and approach to treatment for patients and their families

The meaning of Myxoid in the name of a tumor and what it portends

The role of Neo -antigen vaccines in sarcoma

The most important advancements in sarcoma care in the last 40 years

*Contributors to the episode

Dr.Bob Bell - University of Toronto, Dr. Peter Ferguson - University of Toronto, Dr. Jay Wunder - University of Toronto, Dr. Paul Clarkson - University of British Columbia, Dr. Will Eward - Duke University, Dr. Shannon Puloski - University of Calgary, Dr. Mathew Houdek - Mayo Clinic, Dr. Jennifer Nevin- University of British Columbia, Dr. Anna Kulidjian- Scripps Health, David Wilson - Dalhousie University, Frank O’dea - Memorial Hospital, Alexander Lazarides - Moffitt cancer center, Burke Zachary - University of Toronto, Anthony griffin - University of Toronto.

In this episode we discuss benign bone cysts. Unicameral Bone cysts also known as UBCs and Aneurysmal bone cysts also known as ABCs.

Unicameral bone cysts are simple bone cysts that occur in children and young adults with a predilection for the metaphyseal region of the bone. They are often found incidentally but can also lead to a fracture of the weakened bone.

Aneurysmal bone cysts are blood filled cysts that cause pain, they also occur in children and young adult with a predilection for the metaphyseal region. They can cause pain and sometimes mimic other entities.

Links

Subramanian S, Kemp AK, Viswanathan VK. Bone Cyst. [Updated 2022 Jan 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539849

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

As part of our series featuring Sarcoma patients/ survivors and their stories we discuss with Brandi Benson. An Ewing sarcoma survivor, Entrepreneur, veteran, author and much more. We discuss her amazing journey from diagnosis to present.

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Ewing sarcomas are rare malignant tumors that occur in children and young adult. Ewings' can occur in bone and soft tissue. Ewing sarcomas are high grade with risk of metastasis to the lungs, bone and bone marrow. In this episode we discuss the diagnosis, management and treatment of this Sarcoma with our guest Dr. Lindberg.

Links & Article(s)

Zöllner SK, Amatruda JF, Bauer S, et al. Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives. J Clin Med. 2021;10(8):1685. Published 2021 Apr 14. doi:10.3390/jcm10081685