Science (Audio)

Blood-forming stem cells replenish the blood and immune system, making them important targets for gene therapy and transplantation. Cynthia Dunbar, M.D., explains how genetic barcodes let scientists track individual stem cell clones over time. Long-term studies in nonhuman primates reveal stable contributions from blood stem cells and unexpected persistence among certain natural killer immune cells. Dunbar reviews successes and safety concerns in gene therapy, including leukemias associated with some integrating viral vectors. She compares these approaches with CRISPR gene editing, examining challenges in precise gene insertion, stem cell recovery after transplantation, and age-related clonal hematopoiesis. She also addresses treatment costs, intensive preparation for transplantation, and barriers to patient access. These insights help researchers evaluate new treatments more carefully and work toward safer, more accessible care. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40858]

Photography makes environmental changes visible that are difficult to recognize in everyday life. James Balog, Founder and Director of the Earth Vision Institute, describes his shift from celebrating nature’s beauty to documenting how human activity reshapes the planet. His photographs range from endangered wildlife and towering trees to mines, wildfires, and the atmosphere above Earth. Through the Extreme Ice Survey, Balog uses time-lapse cameras to show glaciers retreating over time, making climate change visible through recorded images. Drawing on his work and the films Chasing Ice and The Human Element, he examines the connections between people, land, air, water, and ice. Balog also considers society’s reliance on fossil fuels and the possibility of constructive environmental action. His images show why these changes matter to people and future generations.

Series: "Jeffrey B. Graham Perspectives on Ocean Science Lecture Series" [Science] [Arts and Music] [Show ID: 41838]

Heart repair is moving beyond a single strategy. Catriona Jamieson, M.D., Ph.D., Ehtisham Mahmud, M.D., FACC, FSCAI, Eric Adler, M.D., Karen Christman, Ph.D., and set designer Robert Brill discuss approaches to preventing and repairing heart damage. Mahmud describes a model linking cardiovascular care, training and clinical research. Adler explains how patient skin cells can be turned into beating heart cells to study genetic cardiomyopathies and develop targeted therapies. Christman discusses injectable extracellular matrix materials designed to reduce inflammation, limit scar formation and support repair after a heart attack. Brill connects the science to The Heart, a theatrical work shaped by medicine, organ donation and community. Together, the discussion shows how collaboration across medicine, bioengineering and the arts can expand approaches to heart disease and healing. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41544]

Grecia Paola Siono Gutierrez and Jose Enrique Siono Gutierrez share how family, mentorship and community shaped their path from Mexicali to studying electrical engineering at UC San Diego. The siblings describe beginning at community college, transferring together and adjusting to classrooms where they often saw few students who shared their background. Grecia discusses finding support through the Raza Resource Centro, the Society of Hispanic Professional Engineers and research mentorship, while Jose explains how studying music strengthened his discipline and inspired projects connecting sound and electrical engineering. They also reflect on their parents’ sacrifices, the importance of role models and their own support for one another. Their advice to students is to seek supportive communities, learn from setbacks and keep pursuing ambitious goals even when the path is not straightforward. Series: "Career Channel" [Science] [Education] [Show ID: 41495]

Valley fever, also known as coccidioidomycosis, is a fungal infection that is contracted when soil borne spores are disrupted and inhaled. The infections can cause symptoms similar to pneumonia or COVID-19, such as cough, headache, fever and, in more severe cases, meningitis. UC Davis Health patient Rex shares his journey with valley fever and how UC Davis doctors and researchers are advancing earlier diagnosis and better treatments through clinical care and laboratory science. Series: "UC Davis News" [Health and Medicine] [Science] [Agriculture] [Show ID: 41743]

RNA damage, mentorship and the realities of building a career in science come together in Alex Chaim's work and personal journey. Chaim, principal investigator of the Chaim Lab and assistant professor of cell and developmental biology at UC San Diego, studies whether damage to RNA may contribute to diseases associated with oxidative stress, including neurodegeneration. He also reflects on finding community and learning from mentors throughout his education and career. Chaim describes creating CASAS, a scientific seminar series conducted in Spanish, and explains why he tries to humanize science in both his classroom and lab. His advice to students centers on seeking research experience, finding good mentors and learning from experiments that do not go as expected. His story shows how persistence and community can shape a life in science. Series: "Career Channel" [Science] [Education] [Show ID: 41492]

New research at the UC Davis Center for Mind and Brain is taking a leap forward in understanding how the brain — down to the individual neuron — navigates us through the world to find what we need.

Jack Lin, the study’s principal investigator, is a professor and neurologist who directs the UC Davis Comprehensive Epilepsy Program. Lin works with patients like Travis Rouse. He has epilepsy, and a RNS system implanted into his brain senses when a seizure is coming and sends electrical signals to head it off.

The RNS system collects detailed data on brain activity. Complemented with GPS location data and eye tracking, the research team can record unprecedented information on how Travis navigates the Center for Mind and Brain halls.

When the team analyze the data, they’ll be able to see which individual neurons activated as Travis thought through where he wanted to go and also how his brain got him there. Series: "UC Davis News" [Science] [Show ID: 41731]

Chancellor May stops by the UC Davis Neuroprosthetics Lab to meet the researchers behind brain-computer interface technology. The technology helped a man with ALS communicate again with his family and used AI to mimic the sound of his own voice. Watch as Chancellor May tries out the technology himself in a lab simulation. Series: "UC Davis News" [Health and Medicine] [Science] [Show ID: 41741]

Climate change is fundamentally altering marine environments worldwide. But what does this mean for the creatures that call the ocean home? Join Martin Tresguerres, Ph.D., as he delves into the work of the Allen Discovery Center for Neurobiology in Changing Environments (ADC-NiCE), where researchers are working towards answering this question. Through a combination of neurobiology, physiology and environmental science, ADC-NiCE investigates how climate change affects the nervous systems and behavior of marine animals — ultimately guiding policy, conservation strategies and restoration efforts. Series: "Jeffrey B. Graham Perspectives on Ocean Science Lecture Series" [Science] [Show ID: 41697]

Topology offers a way to organize complex data by looking for shape, structure, and relationships. Yusu Wang, Ph.D., UC San Diego, and Gunnar E. Carlsson, Ph.D., Stanford University, discuss how ideas from algebraic topology move from pure mathematics into data science, machine learning, and AI. Carlsson explains why topological data analysis helps identify meaningful groups in large data sets, how examples and accessible tools can make abstract math useful, and why interpretability matters as AI systems grow more complex. The conversation connects collaboration across fields, customer-focused entrepreneurship, and the need to train mathematicians and AI researchers to help formulate real-world problems. Their exchange shows how mathematical thinking can make powerful technologies more understandable, usable, and accountable. Series: "Data Science Channel" [Science] [Show ID: 41487]