Science (Audio)

Madeline Oudin, Ph.D., is a scientist and mother on a groundbreaking mission to help her daughter, Margot, who has two de novo mutations in the SCN8A gene, which causes epilepsy. Margot's condition causes frequent seizures and developmental challenges. Determined to make a difference, Madeleine and her team are pioneering a cutting-edge genetic therapy that could one day transform treatment for Margot and others like her.

In this heartfelt talk, Madeleine shares how her scientific expertise and personal journey intersect, revealing the highs and lows of developing life-changing treatments. From innovative approaches using Antisense Oligonucleotides (ASOs) to the unexpected success of a ketogenic diet, this story is about resilience, hope, and the power of community. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 40210]

Gloria Yiu, M.D., Ph.D., delves into the transformative potential of genetic editing technologies in addressing rare immune disorders, with a focus on CD3δ severe combined immunodeficiency (SCID)—a condition characterized by impaired T-cell development and severely compromised immune function. Leveraging her expertise as a physician-scientist, Yiu explores how CRISPR and other precision gene-editing tools can correct genetic mutations at the cellular level, potentially restoring T-cell production and immune resilience in patients with CD3δ SCID. Her presentation underscores the challenges and breakthroughs in treating such life-threatening conditions, emphasizing the role of interdisciplinary research, clinical innovation, and ethical considerations in advancing the frontiers of personalized medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40245]

The site of Göbekli Tepe is well known as a settlement of the transitional phase in SW-Asia, in which the greater mobility of the Palaeolithic increasingly gave way to the more permanent settlement of the Neolithic. This talk uses the example of Göbekli Tepe to explore the linkage of buildings with ecology, climate, economy, cultural, political, symbolic systems, and creation of networks between dwellings. The central question is to what extent it is possible to understand how people in the Neolithic constructed their world. Based on this, the talk will challenge the regnant hypothesis that Göbekli Tepe served as a central ritual site and meeting place that acted as a driving force for the spread of Neolithization. This provides an important addition to developing a perspective on the precursor forms of habitation for buildings whose architectural remains we can examine today. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40164]

The infections disease landscape is constantly changing - challenging our standard treatments. Can new - as well as ancient - therapies be the answer? Hear from experts on the cutting edge of phage therapy, HIV/AIDS research and cancer care about what is on the horizon to improve human health. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39982]

John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for treatments to improve recovery after stem cell transplants. He also discusses early findings on potential differences in blood stem cell behavior between men and women and raises questions about how inflammation from severe illnesses, like COVID-19, could impact the blood system as we age. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39949]

This presentation will briefly trace 70,000 years of cultural evolution from the ancient crossing from Sunda to Sahul, via the swift continental colonization during the Ice Age, through the severe impacts on survival during the Last Glacial Maximum, and the socio-territorial reconfigurations during Holocene sea-level rise. The Australian Aboriginal world had become characterized by low environmental impact habitation, complex social organization systems anchored within constructed sacred origin histories, the persistence of relatively simple dwelling types situated within complex settlement sociospatial structures, and a high quality of life for most, with institutional dispute resolution mechanisms to contain conflicts. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40162]

The transition from Neolithic villages to early cities marked the greatest social transformation faced by our species before the Industrial Revolution. Our ancestors had to learn how to live in new settlements that had more people, higher densities, and more activities than had been known previously. The new adaptations to urban life involved changes in society and social processes, not just individual learning. Some changes came about through social interactions in a process called energized crowding; these include innovations in housing and the use of space, and the establishment of neighborhoods in cities. Other changes were driven by powerful new institutions, including formal governments and social classes. Do ancient cities—and they ways they responded to shocks—might hold useful insights for the development of urban adaptations to climate change today? Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40165]

Oil and gas are the most traded commodities on the planet; they are also the chief causes of the most grievous harm our species has yet faced, the burgeoning climate crisis. Bill McKibben is the Schumann Distinguished Scholar at Middlebury College and a founder of Third Act, which organizes people over the age of 60 to work on climate and racial justice. He examines how the export of hydrocarbons, in particular, has become an enormous threat to efforts to rein in greenhouse gasses. It explores the role that America – the world’s biggest exporter of gas – plays in this ongoing catastrophe. And it looks at the role that non-tradeable commodities – sunshine and wind – play in easing this crisis. Series: "UC Berkeley Graduate Lectures" [Science] [Show ID: 40220]

Humans construct their physical worlds in part by designing and constructing new tools, habitations, and in due course diverse buildings and, in some cases, towns and cities and construct their symbolic worlds by putting words together to tell stories, articulate plans, tell lies, seek truth, and much more. This talk offers hypotheses that address a key question for anthropogeny: How did biological evolution yield humans with the “construction-ready brains” and bodies that made us capable of the cultural evolution that created the diversity of our mental and physical constructs that we know today? Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40161]

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]