Science (Audio)

Catherine Yeung, Pharm.D., Ph.D., M.P.H., discusses groundbreaking advancements in kidney-on-a-chip technology, emphasizing its potential to revolutionize human health. She delves into the role of environmental toxins, such as okra toxin A, microplastics, and plasticizers, in contributing to chronic kidney disease, particularly in regions with specific dietary practices. Yeung also addresses the challenges of replicating adult kidney cells from stem cells, which often retain a fetal phenotype, and underscores the value of stem cell-derived models for genetic manipulation and disease research. Additionally, she highlights the increased risk of kidney stones in astronauts post-spaceflight and the broader implications of organ-on-chip technology for studying therapies and diseases. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39458]

Curious about what happens to our cells as we age and how it affects our health? Shiri Gur-Cohen explores the role of tiny chemical tags on our DNA, like methylation, in influencing our healing and overall well-being. Gur-Cohen discusses how these tags might be shaped by our body's systems, such as the lymphatic system, and could even help repair or regenerate various parts of our body. Gur-Cohen proposes that uncovering these processes could lead to innovative ways to slow aging or boost our body’s natural healing capabilities. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39979]

Learn about the California Transformative Climate Communities Program by taking a journey with UCLA into three communities - Fresno, Ontario and Watts - leading comprehensive, collaborative, equitable, and innovative climate action that changes lives. [Science] [Show ID: 40150]

Since Lucy's 1974 discovery, African heritage management and paleoscientific research have evolved significantly. Partnerships with international organizations have supported these efforts, leading to flourishing research and collaborations. However, foreign researchers' access restrictions have hindered efficiency, innovation, collaboration, and diversity. Balancing access restrictions with scientific openness and responsible stewardship is crucial. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 39826]

Michael Lane, Ph.D., shares his work investigating the effects of cervical spinal cord injury (SCI) on breathing and upper extremity function, focusing on the potential for spontaneous functional recovery, or "plasticity." Lane also discusses efforts to develop and test strategies to promote beneficial plasticity and recovery following cervical SCI, with a particular emphasis on improving respiratory function and activity in respiratory muscles. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39457]

Humans are a spectacular outlier among the millions of species of life on planet earth, with incredibly unique biological success. Slowly, scientists have begun to understand the traits that interacted to make us unique, such as cumulative culture, unique scales of cooperation, cognitive abilities, language, and a unique life history and mating system. However, the sequence of evolutionary events that led to our unique species was very much a mystery until the discovery of early bipedal hominins like the australopithecine, Lucy. Here, Kim Hill explains how we have learned so much about this improbable sequence and evolutionary pathway by discovering that early hominins were fully bipedal but still had small brains and little evidence for human mating and life history patterns or cumulative cultural evolution. Lucy helped us understand why the evolution of bipedality was a critical first step that led to an amazing evolutionary sequence that resulted in our spectacular outlier species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 39825]

Human activities can increase levels of harmful microorganisms and pollutants in our water systems that have the potential to make us sick or threaten our food supply. Join microbial ecologist Dr. Sarah Allard as she presents emerging research from Scripps Oceanography that sheds light on seafood-related food borne illnesses. Series: "Jeffrey B. Graham Perspectives on Ocean Science Lecture Series" [Health and Medicine] [Science] [Show ID: 40082]

The connection between paleoanthropology and primatology began with Darwin's theory of human origins. Lucy's discovery challenged existing ideas, coinciding with observations of wild primates. This sparked a surge of research on primate behavior, enriching our understanding of human evolution. Despite behavior not fossilizing, studying living primates has deepened insights into ancestral lifestyles. By examining their social and ecological dynamics, researchers unravel the origins of complex behaviors like cooperation and culture, shedding light on human adaptations. This interdisciplinary approach has refined methods for studying social processes and their biological effects. Fifty years since Lucy's find, these tools continue to shape our understanding of human evolution and its relevance today.

Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 39824]

Giorgia Quadrato, Ph.D., explores cerebral organoids as models for neural development and disease research. Using live calcium imaging, Quadrato observes increased neuronal coordination attributed to inhibitory neurons, validated through pharmacological and genetic methods. Quadrato contrasts their organoid generation protocol with previous methods, emphasizing complex patterning, long-term cultures, and co-culture with mouse brain cells for improved physiological relevance. Microfluidics are utilized for enhanced oxygenation and physiological conditions. Future efforts focus on incorporating microglial cells for synaptic pruning studies and overcoming challenges in cryopreservation. Overall, the research aims to advance understanding of neural mechanisms and diseases, enhancing organoid fidelity for biomedical applications. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39456]

Lucy's 1974 discovery reshaped our understanding of early hominins. Geological studies dated her to 3.21 million years ago. Questions arose about her life and death, leading to investigations into her burial site and skeletal preservation. Found scattered on the surface, less than 40% of her skeleton was preserved. Some parts were articulated, indicating rapid burial, possibly by a river. Missing elements suggest scavenging and erosion. Debate surrounds her cause of death, with theories including a fall or predation. Bone fractures hint at trauma, but the exact circumstances remain unclear. Geological evidence disputes death by mudslide or flood. Tooth marks on her bones lack conclusive evidence of predation. These debates underline Lucy's enduring influence on paleoanthropology, sparking ongoing research into human evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 39823]