Science (Audio)

Technology is clearly central to human life and evolution but remains hard to define and study. Emory University professor Dietrich Stout discusses an evolutionarily motivated definition of technology that highlights three key features: material production, social collaboration, and cultural reproduction. This perspective has important implications for the way we conceptualize and study the origins and evolution of human technologies. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37385]

This symposium addresses several important distinctly human characteristics that range from molecules, to metabolism, anatomy, disease, and behavior. Goals include transdisciplinary interactions, improved self-understanding, promotion of ethically sound studies to explain known differences, and the generation of new, potentially unexplored, insights on uniquely-human specializations. Given the interest in understanding our evolution, this symposium will also help to organize how and in what sequence distinctly human physical, mental, social, and cultural features evolved. Such understanding may help explain the origin of our species and how it came to now directly shape the planet, giving rise to the Anthropocene (a proposed geological epoch distinguished by human influence on climate and the environment). Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37447]

Humans and many other species have biologically endowed abilities for discriminating “quantities” to some degree (e.g., subitizing), but only humans, via the distinct capacity of “symbolic reference” exhibit “number” — i.e., exact symbolic quantification. Language, with its symbolic properties although present in all human cultures, is a necessary condition for “number” but it is not a sufficient condition for it. UC San Diego professor Rafael Nuñez discusses the comparative analysis of “quantity” and “number”, and the implications it has for debates about the origins of other human special capacities such as geometry, music, and art. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37386]

The impacts of climate change and the urgency to act have not gone unnoticed in Latin America and the Caribbean (LAC). The Institute of the Americas (IOA) has released a policy white paper entitled, Nationally Determined Contributions Across the America: A Comparative Hemispheric Analysis in an effort to better assess progress made to date by countries across the Americas in delivering on their climate commitments. The white paper provides a timely snapshot of progress made, while also highlighting the serious funding gaps that remain if LAC countries are going to deliver on their previously agreed upon climate pledges. Series: "Climate Crisis" [Public Affairs] [Science] [Show ID: 37455]

Sialic acid-recognizing immunoglobulin-type lectins (Siglecs) are a family of cell surface proteins prominently expressed on immune cells in mammals. Siglec-11 is an example of an inhibitory Siglec. It was the first protein in the brain found to be “human-specific”: non-human primates express Siglec-11 in other tissues but not in the central nervous system. UC San Diego School of Medicine professor Ajit Varki discusses the importance of Siglec-11 and the paired receptor Siglec-16, and how they play significant roles in regulating inflammation, and have several uniquely human features including expression in brain. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37380]

Language is a human cognitive specialization, and as such, is expected to be supported by human neurological specializations. The arcuate fasciculus is a white matter fiber tract that connects Wernicke’s and Broca’s language areas in the human brain, and also connects the homologues of Wernicke’s and Broca’s areas in non-human primate brains. Emory University professor James Rilling discusses the difference of arcuate fasciculus between human and non-human primate brains and how the specialization of speech has helped humans evolve. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37381]

During embryogenesis, the three germ layers (endoderm, ectoderm, mesoderm) differentiate into epithelial and non-epithelial cells, which eventually form differentiated tissues and organs. Abundant data now indicates that we humans are very closely related to other hominids including chimpanzees, bonobos, gorillas, and orangutans, the so-called "great apes". UC San Diego School of Medicine professor Nissi Varki discusses the incidence of carcinomas, including the rarity of occurrence of common human carcinomas in captive chimpanzees. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37382]

Diet has played a major role in the evolution of human and non-human primate digestive systems. Phytanic acid is a potentially toxic branched chain fatty acid that can be acquired in humans by ingesting plant and/or animal products. Although it was established that humans cannot derive phytanic acid from chlorophyll and instead normally obtain it only from meat, dairy, and fish products, less was known about the capacity of non-human primates with proportionally larger hindguts to obtain phytanic acid from plant materials. University of Southern California professor Joseph Hacia discusses studies profiling phytanic acid levels in red blood cells obtained from humans and captive non-human primates all on low phytanic acid diets. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37379]

Elly Tanaka of the Research Institute of Molecular Pathology (IMP), Vienna Biocenter shares her work defining what it means to have successful regeneration and studying examples of lack of regeneration and what that means at the cellular and molecular levels. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37019]

ABO Blood groups represent the first described human molecular polymorphism. The ABO gene encodes variants of a protein (a glycosyltransferase) that produces the short sugar chains on glycoproteins and glycolipids that define the A, B, or O antigens. These antigens are found on red blood cells, plasma glycoproteins, and other cell types in various tissues. Individual humans can have one of four blood types based on the two alleles inherited from both parents at the ABO locus: blood type A, B, AB, or O. UC San Diego professor Pascal Gagneux discusses how recent comparative genome studies have revealed that this polymorphic system is ancient and shared between humans and non-human primates, this despite the fact that none of the great ape species carries all four ABO blood types. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 37378]