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Science TLDR
By Raymond RuffScience
Science TLDR episodes
- Guidelines for Early Food Introduction and Patterns of Food Allergy
https://doi.org/10.1542/peds.2024-070516
15 min - Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design
https://doi.org/10.1080/19420862.2025.2570748
16 min - A genetic common factor underlying self-reported math ability and highest math class taken
https://doi.org/10.1038/s41380-025-03237-0
17 min - Profiling Hinge Plasticity in Intact Monoclonal Antibodies for Antigen Recognition
https://doi.org/10.1021/acs.biochem.5c00274
14 min - The impact of CD3 affinity-attenuation on T cell engaging bispecific antibodies: is it really that simple?
DOI: 10.1080/17460441.2025.2522088
18 min - Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy
https://doi.org/10.1016/j.cell.2025.07.046
20 min - Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy
https://doi.org/10.1038/s41586-025-09370-8
21 min - AlphaEarth Foundations: An embedding field model for accurate and efficient global mapping from sparse label data
arXiv:2507.22291v1
19 min - Single-Chain Fab Chain-Exchange (scFab-PACE) converts targeted prodrugs into functional T cell engagers on tumor cells
https://doi.org/10.1016/j.jbc.2025.110490
17 min - Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement
https://doi.org/10.1016/j.celrep.2025.115965
13 min
About Science TLDR
From the publisher's feed
Ten-minute paper summaries for scientists and experts.
Two episodes a week: Mondays feature the top-scoring paper from a curated weekly digest of T cell engager, bispecific antibody, and…
protein engineering literature. Fridays cover the top trending paper on PubMed — any field, whatever's catching the research community's attention that week.
Hosted by Raymond Ruff, a protein scientist working in translational immunotherapeutics. Audio is generated with NotebookLM; the host prompt aims for measured scientific skepticism rather than hype.
Feedback and paper suggestions: [email protected]