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Science TLDR
By Raymond RuffScience
Science TLDR episodes
- Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity
https://doi.org/10.1038/s41586-025-08997-x
14 min - Deep-learning-based single-domain and multidomain protein structure prediction with D-I-TASSER
https://doi.org/10.1038/s41587-025-02654-4
12 min - 13 min
- Adversarial testing of global neuronal workspace and integrated information theories of consciousness
https://www.nature.com/articles/s41586-025-08888-1
10 min - Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease
https://doi.org/10.1038/s41586-025-08852-z
14 min - A natural experiment on the effect of herpes zoster vaccination on dementia
DOI: 10.1038/s41586-025-08800-x
12 min - The end of the genetic paradigm of cancer
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003052
26 min - Embodied large language models enable robots to complete complex tasks in unpredictable environments
https://www.nature.com/articles/s42256-025-01005-x
13 min - Sequencing by Expansion (SBX) – a novel, high-throughput single-molecule sequencing technology
https://www.biorxiv.org/content/10.1101/2025.02.19.639056v1
15 min - CD33–CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells
DOI: 10.1158/2643-3230.BCD-23-0258
9 min
About Science TLDR
From the publisher's feed
Ten-minute paper summaries for scientists and experts.
Two episodes a week: Mondays feature the top-scoring paper from a curated weekly digest of T cell engager, bispecific antibody, and…
protein engineering literature. Fridays cover the top trending paper on PubMed — any field, whatever's catching the research community's attention that week.
Hosted by Raymond Ruff, a protein scientist working in translational immunotherapeutics. Audio is generated with NotebookLM; the host prompt aims for measured scientific skepticism rather than hype.
Feedback and paper suggestions: [email protected]