For a long time, deformities of the chest wall, such as pectus excavatum, a condition where the chest appears to have sunken, remained untreated or were treated using crude and invasive techniques. However, thanks to innovations led by surgeons such as Prof. Donald Nuss of Eastern Virginia Medical School, these procedures have undergone a remarkable transformation. Such work has shifted the paradigm from radical surgery to minimally invasive solutions, changing lives and restoring confidence for countless patients. Now, a Review Article published in the African Journal of Thoracic and Critical Care Medicine, and co-authored by Prof. Donald Nuss and Dr. Ivan Schewitz of the Department of Cardiothoracic Surgery at the University of Pretoria, South Africa, charts the remarkable progress in treating pectus excavatum.

In many regions around the globe, common mental health issues are cloaked in secrecy by those who experience them, and are frequently stigmatized and misunderstood by others. This is a particularly serious issue in conservative communities, where cultural and religious values have significant effects on the provision and use of appropriate mental health care resources. In a new mini-review article published in the journal Frontiers in Public Health, Dr. Mabrouka Abuhmida, Dr. Wendy Booth and Dr. Felix Anyanwu of the University of South Wales in the UK, have explored this critical topic, revealing the damaging impact of stigma in such communities, and exploring new solutions to enable adequate mental healthcare in this context.

Research by Dr. Claudia Ituarte-Lima and Dr. Radu Mares at Lund University examines how a pioneering environmental agreement in Latin America and the Caribbean introduces new ways of protecting nature and human rights. Their study reveals both opportunities and challenges in how this regional treaty interacts with European Union trade laws, offering insights into how different regions can work together to protect the environment and strengthen democracy.

Research by Professor Will Greaves at the University of Victoria examines how the Trump presidency has impacted the long-standing security relationship between Canada and the United States. His analysis reveals concerning shifts in the foundations of bilateral cooperation and trust between these traditionally close allies, with implications for the future of North American security arrangements.

Imagine living with an illness that can sap your energy levels so completely that even day-to-day tasks, such as doing laundry, walking the dog, or even getting out of bed can be insurmountable challenges. To make matters worse, this illness is not well understood either by the public or by medical staff, and is often dismissed and stigmatised, making it difficult to find understanding or treatment. This is the unfortunate lived experience of many people with myalgic encephalomyelitis/chronic fatigue syndrome (or ME/CFS for short). In a recent Communication article, researcher Caroline Kingdon of the London School of Hygiene and Tropical Medicine, and colleagues, discuss this misunderstood condition through the prism of the 2021 guideline for the treatment of those with ME/CFS, which have been published by the UK’s National Institute for Health and Care Excellence (or NICE for short). Their article aims to inform primary caregivers about the NICE guideline, and, happily, reveals that the new guideline prioritises an overdue shift toward compassionate and patient-focused care for ME/CFS.

Research by Dr. Anne Hultgren and colleagues at the Arnold and Mabel Beckman Foundation demonstrates that blinding reviewers to applicants' institutional affiliations (also known as dual-anonymous reviews) leads to more equitable distribution of research funding opportunities. Their study reveals how removing identifying information helps overcome unconscious biases toward prestigious universities in grant review processes.

Across the varied and diverse landscapes that make up the Nigerian countryside, animals, both wild and domesticated, are more than merely an agricultural commodity or source of food; they are an integral part of local cultures, natural biodiversity, and represent an ecological treasure trove. Local wildlife and agricultural livestock help to sustain the livelihoods of millions. However, beyond this, Nigerian animals hold secrets within their genetic code that could, when revealed, help to prevent diseases, aid conservation efforts and enhance agricultural productivity. Leading the efforts to uncover useful and interesting genetic phenomena in these animals is Dr. Adeniyi Charles Adeola of the Chinese Academy of Sciences, who explores the genetic blueprints of Nigerian animals in his pioneering research. From investigating the population dynamics of grasscutters to tackling the genetic roots of prion diseases, Dr. Adeniyi Charles Adeola’s work illuminates both challenges and solutions that impact food security, agriculture, and biodiversity in Nigeria, and far beyond.

Research by Professor Magnus S. Magnusson at the University of Iceland demonstrates surprising similarities between the organization of cellular protein networks and of human societies. He reveals how the invention of writing and, very recently, general education, transformed human civilization in ways that mirror ancient biological developments and emphasises how this makes humans unique.

Sepsis is a critical illness that begins with a simple infection and degenerates into a severe and dysregulated immune response that affects the whole body. This significant immune reaction typically causes widespread inflammation and can progress very rapidly. This can result in serious damage to tissues and organs, potentially leading to organ failure and death. Despite the severity of sepsis and its frequent poor prognosis, effective treatments are still elusive, and many sepsis patients remain at high risk of death and serious complications. Part of the issue is the complex cascade of cellular and biochemical events that underlie sepsis, which has made it difficult to obtain a comprehensive overview of the illness from which to design an effective treatment. Dr. Roberta Martinelli, Executive Director of Stromal Immunology and Early Discovery, Discovery Immunology, Merck, and colleagues, have published a study in the journal iScience which reveals new insights into the complex biological milieu underlying sepsis, and uncovers pathways and potential treatment targets that could change how we diagnose and treat this life-threatening illness.

Research by Professors Bernd Schlipphak and Oliver Treib, both of the University of Münster, along with Doctor Constantin Schäfer of ifok GmbH, Germany, reveals how people's sense of global identity influences their support for international organizations. Their work demonstrates that reforms to international organizations can have opposing effects on different groups of citizens, potentially increasing societal divisions about global cooperation.