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In recent years, natural products such as kratom, which derives from a Southeast Asian tree called Mitragyna speciosa, and cannabidiol (or CBD) which derives from the Cannabis plant, have gained significant popularity for their potential to relieve anxiety, manage pain, and enhance mood. While both substances are often praised by users for their plant-based origins, and are often considered safer than synthetic pharmaceuticals as a result, the scientific community is working to uncover the complexities behind how these compounds interact, not just with the human body but with each other. After all, plant-based compounds are still active, and have the same potential for benefit and harm as any drug. People who use kratom are also more likely to use CBD, meaning that they could potentially experience a drug interaction if both substances are ingested around the same time. A recent study by Dr. Erin Berthold and her colleagues at the University of Florida sheds new light on the pharmacokinetic interactions between kratom and CBD, revealing findings that are both fascinating and important for public health.

We think of our brains as safe and secure within our skulls, and not easily influenced unless we consume a mind-altering substance, suffer a traumatic injury or undergo invasive brain surgery. However, recent research shows that our brain activity can be influenced non-invasively using nothing but sound and that this technique could have therapeutic potential. As a postdoctoral researcher at UC Berkeley, Dr. Ben Sorum began to think about these types of question while in the Lab of Dr. Stephen G. Brohawn. Now, Dr. Sorum’s current research at Cooper Medical School of Rowan University explores how ultrasound, which can be non-invasively administered from outside the brain and through the skull, can activate specialized proteins in brain cells, changing their activity. The technique, if further developed, may play a key role in the future of neuromodulation, a field with enormous potential for treating neurological disorders.

In recent years, plant-based diets have gained significant traction, not just among vegetarians and vegans but also among individuals looking to improve their health and reduce their environmental impact. Increasing public awareness of the role of animal food production in driving climate change, along with the potential health risks of consuming large amounts of animal foods has powered this phenomenon. However, one of the ongoing debates in nutrition revolves around protein, a crucial nutritional component, and the nutritional quality of various protein sources. Can plant-based protein sources provide sufficient, high-quality protein compared with animal-based protein sources in the context of a dietary pattern? The question relates to consumer awareness and education, as not all plant proteins are created equal, and replacing meat, diary, and other animal proteins with just one or two plant protein sources may not provide everything we need nutritionally. Rather, a mix of plant protein sources may be required as an adequate replacement for high quality animal protein. As consumers increasingly replace animal proteins with plant proteins, potentially without awareness of these issues, is the overall quality of the protein they are consuming decreasing? Dr. Christopher Marinangeli of Protein Industries Canada and his colleagues set out to answer this question in their research on the effects of increasing plant protein intake on protein quality and nutrient consumption among U.S. adults.

Words change their meanings over time, but tracking these changes has traditionally required painstaking manual analysis by linguists. In recent years, researchers have been using computational models to automatically detect when semantic change happens, and how much of a change has occurred. Recent research led by Associate Professor Nina Tahmasebi and her colleagues in the Change is Key! program introduces innovative computational methods for detecting qualitative features of semantic change, opening new possibilities for understanding language evolution at scale.

Performing at your best when it matters most is something a lot of people struggle with. You can prepare for days, even weeks, but the moment you step on stage, walk into an interview, or face a big audience, things shift. Suddenly, what felt solid in practice starts to slip. I'm Dr. Oksana Komarenko. I teach at Ball State University, and I’m also an opera singer. I know what it’s like to face high-pressure moments. During my first major solo recital, my hands started shaking so badly I could barely control them. Everything I had rehearsed felt just out of reach. And I’m not the only one. Research shows that over 77 percent of performers experience the same thing when the pressure is on.

Recent research from Professor Maryam Mehrnezhad at the Information Security Department, Royal Holloway University of London and a team of researchers reveals widespread privacy, security and regulatory failings in female-oriented health technologies (also known as FemTech). The researchers’ comprehensive analysis demonstrates how current practices leave sensitive health information vulnerable, while highlighting an urgent need for reform across technical, legal and social dimensions of digital healthcare.

The African turquoise killifish, also called Nothobranchius furzeri, is a small, vibrant freshwater species that is making a big splash in aging research. With our aging populations, research into aging and the mechanisms underlying age-related health issues is increasingly important. Scientists in this valuable field prize the killifish because it has a significantly short lifespan at just six to twelve months, making it an ideal model to study age-related diseases. However, as research on this species grows, so does the need for better care and monitoring of their health. In fact, distinguishing between the natural effects of aging and other health issues in these fish, such as pathogens or disease, is crucial in accurately researching age-related phenomena. Moreover, identifying health issues in laboratory fish could help researchers to better maintain health in their fish stocks, improving both experimental results and animal welfare. This is where Dr. Beate Hoppe and her colleagues at the Leibniz Institute on Aging at the Fritz Lipmann Institute, Jena, Germany, step in, pioneering a comprehensive approach to monitoring and managing killifish health that could revolutionize laboratory fish research.

Employers and other decision makers typically use interviews to make their final decision on candidates applying for important positions. The process begins by reviewing resumes, and checking references, before the final and typically most important act, the interview. Within mere minutes, an interviewer can form a strong impression of a candidate. For instance, this may run along the lines of “this person seems confident, articulate, and driven” or “this person does not represent themselves well, and likely won’t be a good fit”. By the end, the interviewer may feel that they truly understand the candidate. But what if that feeling is just an illusion? This is the question tackled by Prof. Jason Dana of Yale University and his colleagues in their research on unstructured interviews. Their findings challenge one of the most common hiring and admissions practices: the belief that sitting down with a candidate and having a free-flowing conversation reveals valuable insight. In reality, their study suggests that unstructured interviews often do more harm than good, leading decision-makers to rely on misleading impressions rather than objective facts.

Colorectal cancer is a significant health challenge, and ranks as the second leading cause of cancer-related death and the third most common type of cancer in the United States, among men and women combined. Each year, over 52,000 people in the U.S. die from colorectal cancer, with more than 5,300 deaths occurring in California alone. While early detection of colorectal cancer through screening can significantly reduce both its incidence and mortality, ensuring that screening programs remain effective and sustainable is no small feat, particularly in the face of uncertain funding. This pressing issue is at the heart of recent research conducted by Dr. Ndukaku Omelu of the California Department of Public Health, and colleagues, who examined the sustainability of colorectal cancer screening strategies implemented through the California Colon Cancer Control Program (or C4P for short), with a particular focus on how these screening programs would fare in the absence of future C4P funding, a program funded by the Centers for Disease Control and Prevention (or CDC for short).

In order to operate safely and efficiently, lithium-ion batteries rely on battery management systems to monitor their state and to control their operation. An essential part of this process is modelling battery behaviour under different conditions to predict performance and prevent failures. To do this efficiently, it is crucial to simplify the underlying physical processes, while sacrificing as little accuracy as possible. Through their research, Dr. Luc Raijmakers and colleagues at the Jülich Research Centre, Germany, compare various different approaches to simplifying simulations. Their results could make it easier for battery operators to decide which approach is best suited to their requirements for accuracy and computational efficiency.