SciPod

Pulque, an ancient Mexican beverage, is making waves in the scientific community—not just as a cultural relic, but as a potential health-boosting powerhouse. A team of researchers, including Prof. Rogelio Valadez-Blanco, Dr. Yesica Ruiz-Ramírez, and Prof. Paula Guadarrama-Mendoza, from Universidad Tecnológica de La Mixteca, has been investigating the hidden potential of the bacteria found in this traditional drink. Their findings suggest that pulque’s naturally occurring lactic acid bacteria could play a key role in promoting gut health and even combating harmful pathogens that cause foodborne illnesses.

As an inherently brittle material, concrete often needs to be replaced after just a few decades: driving a demand which incurs significant costs for Earth’s climate. Through their research, Professors Suzanne Scarlata and Nima Rahbar at Worcester Polytechnic Institute, Massachusetts, introduce a new mechanism that allows concrete to quickly repair itself, with the help of an enzyme vital to the function of living cells. This approach could help to reduce the world’s insatiable demand for concrete.

In the age of big data, and particularly in specialisations such as artificial intelligence, biology, and medicine, researchers often generate large and complex datasets that are challenging to analyse. This is particularly true for multi-view data, otherwise known as multimodal data, which are data that encompass multiple perspectives concerning a single entity or phenomenon. In the case of single-cell genomics, for instance, researchers can measure a huge range of different characteristics concerning an individual cell, such as RNA expression levels or protein levels. While multi-view datasets provide vast amounts of information, they are difficult to analyse because looking at each type of data within them provides only a small part of the overall picture. A new computational approach called Covering Point Set-merge analysis, or CPS-merge analysis for short, has been developed by Lixiang Zhang of Pennsylvania State University and colleagues, and it aims to assist researchers to merge the different types of data present in multi-view datasets into one coherent and meaningful set of results, without misrepresenting the individual contributions of each type of data.

In the future, doctors will be able to create tiny replicas of your tissues in the lab, and then test them against a range of drugs, revealing exactly which treatments would work best for you before you even visit a drug store. This future of personalised medicine is driven by researchers such as Dr. Robert Kass of the Columbia University Medical Center. Kass and colleagues have pioneered the use of stem cells to develop personalized treatments for a genetic heart condition that disrupts normal heart rhythms. The researchers reprogrammed a patient's skin cells into stem cells called induced pluripotent stem cells (or iPSCs for short), and they then induced the iPSCs to turn into heart cells. This allowed the research team to study how genetic mutations in the resulting heart cells affect the heart’s ion channels. Their research revealed that a mutation in a specific sodium channel was causing dangerous heart rhythms and that combining the drug mexiletine with a pacemaker device to increase heart rate, provided an effective and personalised treatment.

Huntington disease (HD) is an inherited and progressive neurological disorder which is currently fatal. Dr James E. Goldman and Dr Osama Al-Dalahmah, both at Columbia University, USA, are utilising new techniques in molecular biology to better understand the brain pathology associated with HD. Their vision is to develop therapeutics that can slow the progression of the disease, and ultimately, treat and even prevent it.

So far, approaches to mapping the density of cities have often been oversimplified, causing them to overlook many key aspects of everyday urban life. Through his research, Dr Elek Pafka at the University of Melbourne introduces two new metrics for measuring urban density, which better capture its complex, multi-scale variations. His research offers deeper insights into how people experience and interact with cities, and could lead to new strategies to make our cities more productive, sustainable, and better places to live.

Antimicrobial resistance (or AMR for short) is a pressing global health challenge that poses significant risks, particularly in low- and middle-income countries. The extensive research conducted by Saffiatou Darboe of the London School of Hygiene and Tropical Medicine, The Gambia, and her colleagues, has been pivotal in understanding and addressing this issue within The Gambia and other regions in sub-Saharan Africa. This episode delves into four comprehensive studies conducted by Darboe and colleagues, shedding light on the impact of AMR, the importance of antibiograms, and specific outbreaks of resistant pathogens.

As cannabis prohibition begins to unravel across the world, cannabis use has become more common and normalised. Researchers are assessing the impact of this on vulnerable populations, such as pregnant women. Strikingly, cannabis is among the most commonly used substances during pregnancy, raising serious concerns about its effects on unborn children and the long-term consequences this could have. Prof. Miranda Reed of Auburn University, and colleagues, have assessed how cannabis exposure in the womb can affect brain development and cognitive abilities, such as memory.

Voluntary Sustainability Standards have emerged as influential tools to promote sustainable practices in global value chains and are becoming increasingly relevant in the context of new legislation by the European Union and other governments for the promotion of sustainable development. A comprehensive review led by Axel Marx at KU Leuven examines the evolution, impacts, and challenges of these standards, offering insights into their role in global governance and sustainable development.

In principle, travelling wave reactors offer a safe, highly efficient approach to generating nuclear power. However, development has been held back by a variety of challenges linked to the need for extensively high burn-up in the reactor core, meaning very high rates of generated energy which can damage the reactor. Inspired by the principles of Tai-Chi, a team led by Di Yun from Xi’an Jiaotong University has shown that with the right approach, a high temperature operation, usually deemed as a threat, can be transformed into useful advantages, bringing the practical rollout of travelling wave reactors one step closer to reality.