SciPod

On the 26th of June 2015, the US Supreme Court legalised same-sex marriage across the USA, allowing same-sex couples to be legally recognised as married in all 50 states. In a study conducted one year later, Dr Kristina B. Wolff at The Dartmouth Institute for Health Policy & Clinical Practice, explored some of the benefits and costs of this legalisation for LGBTQ+ communities living in the USA. She introduced a new framework, based on the work of economist Dr Amartya Sen and philosopher Dr Martha Nussbaum, that could encourage long-lasting positive social change.

The 20th Century philosopher Hannah Arendt grounded ethics in aesthetics because she viewed art as a way of understanding how the world appears to different people. In her recent work, Professor Andreea Deciu [day-chew] Ritivoi [ree-tee-voy] of Carnegie Mellon University highlights Arendt’s rich repertoire of literary writings, as she believes that they deserve to be considered alongside other popular ethical works. Professor Ritivoi shows how Arendt’s unique contribution identifies the obstacles facing ‘human togetherness’, so that we can find ways to overcome them.

Interstellar space may seem like the last place you would look when searching for the chemical origins of life. Yet on the surfaces of tiny dust grains within this vast expanse, complex chemical reactions are continually occurring, which likely played a key role in establishing the rich diversity of complex molecules we observe in the solar system today. In a new study, astrochemists in Spain and Italy, led by Albert Rimola at the Autonomous University of Barcelona, examine how advanced simulation techniques can be used to study these important processes on atomic scales.

Cellular senescence [suh-NEH-Sns] is the process by which cells age and permanently stop dividing but do not die. While the process of senescence creates a barrier to tumour formation, it can still be overcome by cancer cells. Sebastian Igelmann, a PhD student supervised by group leader Dr Gerardo Ferbeyre at the University of Montreal, has identified a group of enzymes that work together to reprogramme cellular metabolism. This work provides important insight into how tumour cells may initiate proliferation and circumvent senescence. Critically, this specialist group of enzymes provides a potential therapeutic target for human cancer treatment.

Despite their numerous side effects, opioid drugs and morphine-like agents have remained a pillar in the medical management of pain. Most clinically used opioid drugs act through mu opioid receptors. Dr Ying-Xian Pan and his team from the Rutgers New Jersey Medical School, USA, studies the molecular and cellular mechanisms of mu opioid receptors and aim to develop novel strategies and opioid analgesics for better treating pain without side effects associated with traditional opiates. Efforts to find substitutes for traditional opioid drugs are helping address the opiate abuse crisis that affects many countries around the globe.

Identifying the cause of an illness in a sick baby or child is not always easy, particularly if the disease is rare. Throughout his career, Dr Michael Wangler, at the Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute, has investigated rare childhood diseases. Combining his expertise in paediatrics and genetics, Dr Wangler utilises genomics, metabolomics and the humble fruit fly to identify the genes responsible for rare and undiagnosed diseases to improve both diagnosis and treatment.

Glioblastoma multiforme is an aggressive and life-threatening form of brain cancer. Although some treatments are available to provide comfort and prolong life, it remains an incurable and devastating disease. With the goal of advancing diagnostics and treatments for glioblastoma, Dr Hernando Lopez-Bertoni is carrying out exciting research at the Johns Hopkins University School of Medicine. Taking on board the cancer stem cell hypothesis, Dr Lopez-Bertoni has made fascinating discoveries into how miRNA genetic material can be utilised and how it could be delivered to the brain via nanoparticles.

By asking their students to complete self-assessment exercises, educators can encourage the development of their students. These methods rely on a student’s ability to evaluate their own skills, knowledge, and other qualities, and use their self-assessment to make improvements. Professor Heidi L. Andrade [An-drah-day] at the University of Albany recently reviewed 76 empirical studies focusing on student self-assessment. Her review paper offers interesting insights about the effectiveness of self-assessment and its association with achievement and self-regulated learning.

One of the main priorities of the United Nations and other international organisations is to encourage the sustainable economic, social, and environmental development of all countries worldwide. Education plays a crucial role in these efforts, as it allows individuals to become more knowledgeable about matters of public interest, while potentially improving their life skills. Researchers at Purdue University and Michigan State University have created Scientific Animations Without Borders, a platform that produces and disseminates educational animations in numerous languages and dialects. A recent paper authored by Dr María Angeles Rodriguez-Domenech of the University of Castilla-La Mancha in Spain discusses the potential of this innovative platform as a tool for sustainable development.

The Science, Technology, Engineering, and Math (STEM) communities have a long history of exclusion and underrepresentation of women, African American, Latinx, American Indian and LGBTQIA+ students. In order for our STEM enterprise to be truly equitable, everyone that wants to become a scientist must have an equitable opportunity to do so, regardless of their gender, ethnicity or sexual orientation. In the movement toward equity, the demographic diversity of the STEM workforce must mirror that of the general population. STEM workforce diversity can accelerate innovation in scientific disciplines, and, if coupled with systemic cultural equity, can also support a STEM enterprise where everyone can thrive. Dr Verónica A. Segarra, Interim Chair and Assistant Professor of Biology at High Point University, has been exploring how scientific societies could help their disciplines be more equitable. Her efforts have helped to establish numerous alliances and collaborations among societies and diversity-focused organisations, with the mission of building a more diverse and inclusive STEM workforce.