The far-reaching benefits of nanopore research encompass fields as diverse as physics, healthcare, big data processing and environmental studies. At the University of Illinois at Urbana-Champaign, Dr Jean-Pierre Leburton is conducting research focused on the use of nanopores in ultrathin solid-state molecular materials, such as graphene and 2D transition-metal dichalcogenides, for DNA sensing applications. This offers a low-cost and highly effective method of identifying biomolecules, and could have widespread medical applications, enabling rapid, early and effective disease diagnosis and prompting effective treatment, as well as providing invaluable technologies for assisting with DNA sequencing.

The spaces in between galaxies may be unimaginably vast, but within galactic clusters, they are far from empty. Rather, these expanses are home to a wide range of interplaying, often violent plasma dynamics. In his research, Dr Tom Jones at the University of Minnesota plans to use cutting-edge computer techniques to simulate these processes – shedding new light on physical properties that have eluded astronomers so far. His team’s research will not only give crucial insights into some of the largest structures in the known universe, but will also capture the public imagination, and inspire a diverse new generation of astronomers.

Modern industrial agriculture has helped farmers meet rising food demands, but these practices are contributing to a range of environmental problems. Regenerative agriculture holds promising solutions that could help to restore and maintain healthy ecosystems and contribute to climate change mitigation, while keeping pace with food demands and enhancing farmers’ resilience to environmental stressors. Through her research, Dr Hannah Gosnell aims to understand what motivates cattle and sheep farmers – also known as ranchers – to adopt and sustain the use of regenerative practices and what challenges must be navigated. Her work is informing efforts that encourage farmers to transition to these methods.

Choosing which drug molecule to build is only one part of pharmaceutical research; medicinal chemists also need to know how to synthesise drug molecules in an efficient and cost-effective manner. Dr Oscar Verho and his team at Uppsala University in Sweden have made significant progress in this area and are aiming to reduce the time and resources needed to make drug compounds. The team is researching methods to ‘activate’ the carbon-hydrogen bonds that are commonly found in organic molecules to ultimately shorten the synthetic route to the required compound.

Research investigating the adoption of new technologies can help to unveil global trends in learning and education. Researchers at Michigan State University, University of Illinois Urbana Champaign, Texas State University and Purdue University have recently carried out a study investigating the use of devices by people in different parts of the world and with various literacy levels to access YouTube videos between 2013 and 2018. Their analyses identified key historical moments when the use of smartphones for online learning surpassed that of other information and communication technologies.

Despite advances in agricultural science, communicating best practices to farmers in remote areas remains difficult. Although mobile learning tools, such as animated videos, have the potential to effectively present new information to diverse, isolated audiences, their long-term efficacy is poorly understood. A team of researchers from the Agricultural Research Institute of Mozambique, Michigan State University and Iowa State University followed up with farmers in Mozambique two years after receiving video-based, mobile instruction. Their findings suggest these methods are just as successful as in-person teaching styles in improving farmers’ ability to retain and use new information.

Dietary antioxidants, such as vitamin C, are known to reduce the negative effects of toxins in mammals by preventing cellular damage caused by reactive oxygen species. However, it is not known whether these antioxidants have a similar protective effect in insects. A team led by Dr Barry Pittendrigh at Purdue University have investigated the adaptive responses of fruit flies to insecticide exposure in the presence of vitamin C. Their work has exciting implications for reducing the threat of insecticide resistance in insect pests.

Insecticide resistance is an ongoing challenge for agriculture and the control of insect-transmitted diseases. In a recent study at Purdue University, a team of scientists led by Dr Barry Pittendrigh [Pitt-uhn-dree] identified a potential chink in the armour of insecticide resistance in fruit flies. If this Achilles’ heel can be exploited, it bodes well for the future control of destructive insects.

Neurodevelopmental disorders range from those on the relatively common autism spectrum to much rarer disorders such as KDM5C-disorder and Weidemann-Steiner Syndrome. Exciting advancements in human genetics have shown that histones – the proteins our DNA wraps around – play a vital role in healthy brain development. Dr Shigeki Iwase from the University of Michigan studies how mutations in the enzymes that regulate histone structure and function can cause cognitive disorders. His work has led to important new discoveries, including how counterpart enzymes can be utilised for therapies.

Epilepsy is one of the most common causes of disability worldwide, but for many patients, treatment fails to be effective. Dr Victoria Morgan and her team from the Department of Radiology and Radiological Sciences at Vanderbilt University Medical Center are using functional connectivity mapping to find out why some patients respond better to treatment and what alternative ways there may be to tackle this debilitating disorder.