It would be difficult for the San Francisco 49ers to have a more difficult week, which began with a huge loss to the Seattle Seahawks. The Niners didn't just lose the game in embarrassing fashion, they also lost starting quarterback Jimmy Garoppolo and tight end George Kittle to potential season-ending injuries.

The Niners' woes continued as nearly all of their healthy wide receivers -- and their top offensive lineman -- will be inactive for the game, after WR Kendrick Bourne tested positive for COVID-19.

Niner Noise Podcast hosts Chris Wilson (@cgawilson) and Robert Morrison (@rs_morrison) break down the team's unfortunate week, which also includes a Thursday Night matchup with the Green Bay Packers.

The Niner Noise Podcast on the 49ers, the FanSided Podcast Network’s San Francisco 49ers pod, is your source for SF 49ers news, in-depth analysis, exclusive interviews, and more.