What causes depression? A chemical imbalance? Nope. A moral failing? Definitely not. What about deficits in the brain's ability to change itself? Maybe.
In this Patreon-only livestream, we will explore the connections between depression and neuroplasticity. Based on the Integrative Model proposed by Rebecca Price and the late neuroscientist Ronald Duman (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047599), we'll take a closer look at how deficits in neuroplasticity may be at the root of depression.
In this livestream, I'll discuss:
- How chronic stress and its impact on brain health can contribute to depression
- The Integrative Model and its implications for understanding depression
- Cognitive Control, The PFC, and Dopamine in Depression
- The impact of depression on key brain regions such as the hippocampus and frontal cortex
- How therapeutic techniques, including psychotherapy and pharmacology may be helping to increase brain plasticity in order to treat depression.
Don't miss out! Patrons at the $4.99 tier and higher will have the opportunity to ask questions and engage in a live Q&A session. See you there!
If you're watching this later and want access to the livestream when it airs, sign up for Sense of Mind's Patreon and get bonus content every month: www.patreon.com/senseofmind .
You'll get:
- Access to these exclusive monthly livestreams
- Written (blog post) versions of all new videos, including this one!
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Links to Content I Mentioned:
- Dr. Ronald Duman's 2014 talk on ketamine and depression: https://youtu.be/yb6ZFCN7eSA
- Dr. Rebecca Price's 2022 talk on ketamine and depression: https://youtu.be/DuotymRcWf0
- Huberman Lab ep. 34 on Depression: https://youtu.be/Xu1FMCxoEFc
- The Social Brain ep. 14 on Neuroplasticity: https://youtube.com/live/9jrQfXaHrKM?feature=share
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References:
- Price, R. B., & Duman, R. (2020). Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model. Molecular psychiatry, 25(3), 530-543. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047599/
- Zhou, F. C., Wang, Y. Y., Zheng, W., Zhang, Q., Ungvari, G. S., Ng, C. H., ... & Xiang, Y. T. (2017). Prospective memory deficits in patients with depression: A meta-analysis. Journal of Affective Disorders, 220, 79-85.
- LeMoult, J., & Gotlib, I. H. (2019). Depression: A cognitive perspective. Clinical Psychology Review, 69, 51-66.
- Dillon, D. G. (2015). The neuroscience of positive memory deficits in depression. Frontiers in psychology, 6, 1295.
- Liberg, B., & Rahm, C. (2015). The functional anatomy of psychomotor disturbances in major depressive disorder. Frontiers in psychiatry, 6, 34.
- Admon, R., Kaiser, R. H., Dillon, D. G., Beltzer, M., Goer, F., Olson, D. P., ... & Pizzagalli, D. A. (2017). Dopaminergic enhancement of striatal response to reward in major depression. American Journal of Psychiatry, 174(4), 378-386.
- Belujon, P., & Grace, A. A. (2017). Dopamine system dysregulation in major depressive disorders. International Journal of Neuropsychopharmacology, 20(12), 1036-1046.
- Whitton, A. E., Reinen, J. M., Slifstein, M., Ang, Y. S., McGrath, P. J., Iosifescu, D. V., ... & Schneier, F. R. (2020). Baseline reward processing and ventrostriatal dopamine function are associated with pramipexole response in depression. Brain, 143(2), 701-710.
- Rutledge, R. B., Moutoussis, M., Smittenaar, P., Zeidman, P., Taylor, T., Hrynkiewicz, L., ... & Dolan, R. J. (2017). Association of neural and emotional impacts of reward prediction errors with major depression. JAMA psychiatry, 74(8), 790-797.
