🚑 How much fluid is too much in septic shock?

The ARISE FLUIDS trial tackled one of critical care's most debated questions: should clinicians prioritize early vasopressors with restricted fluids or continue a more liberal fluid strategy?

📊 Among 963 patients with septic shock, early vasopressors reduced fluid exposure by >1 liter and significantly lowered pulmonary edema (0.6% vs 5.0%; P

🎯 Yet there was no difference in 90-day days alive and out of hospital or mortality.

A landmark study reminding us that in septic shock, physiology is complex and more fluid is not always better—but less fluid is not necessarily superior either. #Sepsis #CriticalCare #EmergencyMedicine #NEJM #MedicalEducation