Filmed in April 2013 at the Shoklo Malaria Research Unit (SMRU) in Mae Sot, and at the Wang Pa Free Clinic and the Mae La refugee camp, this video highlights SMRU's work among Karen and Myanmar refugees, living along the Thailand-Myanmar border. Dr Francois Nosten, SMRU founder and head, discusses SMRU's work, its objectives and challenges. Dr Nosten warns about the growing public health threat posed by parasite resistance to artemisinin-based combination therapies (ACT); the cornerstone of malaria treatment in all malaria-endemic countries.