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There is a pathway in the brain that promotes weight gain
Decreases movement throughout the day (you don’t even notice it!)Increased appetite Stimulated by Ghrelin, cortisol (stress)Sleep deprivation And a pathway to promote weight loss
Increases spontaneous movement NEAT (the biggest thing linked with weight loss)Stimulated by Leptin, Insulin, SerotoninOne reason overweight folks with leptin resistance are more hungryStimulated by a whole host of hormones we will talk about briefly laterStimulated by Stomach stretchYour body sends signals that stimulate one of these pathways.
Hormones that Make that decrease your appetite
- From the pancreas in response to food
Stops the hunger pathway directly A problem if you are insulin resistantAlso causes your body to store nutrients (glycogen in muscle / liver)Stores fat as wellStimulates the pathway making you full, Inhibits the pathway making you hungry. This is at the level of the brainProportional to body fat (less than leaner you are)- We talked about this on another podcast
In response to fat and proteinDecreases stomach emptying (making you feel full longer)Decreases Ghrelin (your hunger hormone)*Weight Loss leads to CCK NOT elevating as much after food
BUT if in Ketosis, normal response of CCK after eating is maintained
GLP-1 (Glucagon-like peptide)
Stimulated by by carbsLower levels in folks affected by obesity, and people with pre-diabetes / diabetesDec liver making glucose (gluconeogenesis)Reduces appetiteDecrease gastric emptying. E.g Trulicity is an example of drug modeled after this. Others from the small bowel:; PYY, OXM, etc.
Things that make you more hungry
- Ghrelin is the more powerful
What stimulates Ghrelin and makes you more hungryStress, sleep deprivation, The expectation of foodWEIGHT LOSS (any)Fasting Ketones inhibit the rise in ghrelin that occurs with weight loss
The pathway that makes you hungry is inhibited by many of the hormones that make you full
- Fructose does not help your brain to register that it is full
E.g candyFruit has fructose but also fiber which causes stomach stretchSo, How can you regulate your appetite
- When you do eat: Protein > Fat > carbohydrates
Eat carbohydrates with fiberBulk helps (stomach stretch)Sleep MoreStress ReductionMindfulness has its place but intuitive eating may not be a good approach if you have metabolic dysfunction
- Plan your day / meal times
So you are not just eating out of boredom or stressIf you just ate, you probably are not hungryWhy do you want to eat?