🧬💤🏃‍♂️ Can lifestyle modify the cardiovascular risk associated with clonal haematopoiesis (CH)?

In this elegant Nature study, investigators demonstrate that sleep and exercise exert mutation-specific effects on CH. Moderate-to-vigorous physical activity was associated with lower prevalence of non-DNMT3A CH in large human cohorts, while mechanistic studies revealed that uninterrupted sleep and exercise can suppress JAK2V617F- and TET2-driven clonal expansion and reduce atherosclerosis. 🔬❤️

The message is clear: lifestyle is not merely preventive—it may selectively reprogram mutant cells and reshape cardiovascular risk. #Cardiology #PrecisionMedicine #CHIP #Atherosclerosis #MedicalPodcasts 🧬🛡️