SUMMARY: Dr. Russell Blaylock presents newly revealed Imaging and Pathologic data confirming his hypothesis that an Acute to Chronic inflammatory cascade, which he calls "Immuno-excitotoxicity" is the underlying cause of this disease process and other CNS degenerative diseases. It is initiated by vaccines, toxins, metabolic deficiencies, which can start this cascade with repeated insults to the cells as in boxing which has a similar immunoexcitotoxic basis leading to Parkinson,s disease. These repeated cellar traumatic episodes lead to a hyperactive state of the microglia in the CNS, the defense cells of the CNS, which then lead to a hyperactive excitatory series of chemical reactions that ultimately destroy the CNS cells and neurons. This hyperactive state of the microglia is called Microglial Priming, which Dr. Blaylock demonstrates in recently revealed work showing microglial activation on imaging studies. In addition to that discovery, a histopathological study, that was ignored from 20 years ago in people from young to 40 years of age with Autistic Spectrum Disorders, reveals the destruction of the neurons, axons, and other cells in the CNS. The authors also show that many inflammatory molecules were elevated as in immuno-excitotoxicity as described by Dr. Blaylock. These findings confirm his hypothesis that Immuno-excitotxicity is the pathological process behind the development of Autistic Spectrum Disorders. This disease has been described as having no known cause or treatment. This disease process is part of new molecular diseases of the 21st century. Should a neurosurgeon know about this new science? You decide. We did by publishing this work. These molecular diseases primarily involve the CNS.

SUMMARY: Drs. Jeremy Omoro and Okemwa present a rare case of Cerebral Plasmacytoma in a 65 year old female with HA and Left parietal swelling and a progressive course of neurological involvement. A bony mass was seen externally involving the bone, but the neoplasm extended into the brain parenchyma. At surgery hyperostosis of the skull was found from a lesion in the brain, a biochemical bone growth related to the tumor. . After a surprise diagnosis was found not to be a meningioma, a diagnosis of plasmacytoma was made histologically and a treatment plan was developed. How would you manage this case from initial presentation to diagnosis and treatment? What would you do with the bone? How is it treated.The authors, with Dr. Okemwa, a pathologist, provide the details and literature review of this pathology. Interesting and Rare case. 32 minutes. (JIA)

SUMMARY: Dr. Ghaus Malik, an internationally recognized expert in the management of Cerebral AVMs, in Part 2 of his Lecture/ Discussion series on the subject, discusses his experience in managing over 800 cerebral AVMs. In Part 2 he presents his experience with Large AVMs, Complex Cerebral AVMs, Embolization; Pediatric Cerebral AVMs, Aneurysms in Pregnancy, Treatment of the Elderly with cerebral AVMs, AVMs with occluded major vessels, Spontaneous obliteration of AVMs, Technical considerations, Limitations of Surgery, His data, and conclusions. Drs. Eric Nussbaum and Ausman comment on their experience with another 600 cases. Excellent Presentation and Discussion of a challenging vascular disease. (65 minutes lecture and discussion.) JIA

SUMMARY: With a team of global scientists, Dr. William Loudon, a Pediatric Neurosurgeon, has developed a unique method of guiding a Mircorobotic device in the CSF pathways to enter the brain tissue and to reach defined targets throughout the CNS for tissue sampling or potential drug delivery at the cellar source of this pathology. This work, done in sheep, is compared to using traditional neurosurgical catheters targeting similar locations in humans. In detailed histological studies, the authors find that there is no difference in tissue damage using the Bionaut (robotic device) compared with catheter use. This pioneering work opens the potential of using this system to obtain tissue samples and for delivering a targeted drug payload to cells. For example, it could be used in obtaining brain stem tissue samples of tumors or to delivering local therapeutics. This research has wide implications in Surgery and Medicine. We look forward to to more publications from Dr. Loudon on this pioneering work. 63 min. (JIA)

SUMMARY: This is the total 120 minute video of the SubSaharan African Grand Rounds from 7/6/25 covering ACom aneurysms, and Cerebral Plasmacytoma. (JIA)

SUMMARY: Wyandotte, a community outside of Detroit has ordered Fluoride to be restored to drinking water, while most developed nations do not have fluoridated water. Portland, Oregon and other cities have or are removing Fluoride from the drinking water. What is the truth? Does Fluoride cause mental IQ changes in the young? Dr. Russell Blaylock reviews the evidence indicating that Fluoride does not prevent dental cavities, contrary to what the American Dental Association states, and it can cause CNS neural damage. You need to know (18 minutes) what are the facts and become a medical advocate in your community. Your patients will want to know. These are the answers to the increasingly more common diseases in the young and chromic diseases in the USA. Give them the web address of this video to watch for themselves.

SUMMARY: The Neurosurgery Team at Memfys Hospital in Enugu, Nigeria presents. a challenging case of young boy who presented with signs of a posterior fossa tumor. After GTR the patient returned in 8 months with recurrent. symptoms and has a second removal of now a Medulloblastoma. The patient recovered and returned in 2 months with a Neurocytoma at the same site. In the interval between surgery 2 &3 the patient had a wound infection and meningitis. What happened? How can this pathology be explained? Also in a review of the ethnic literature , they found different distributions of tumors in each ethnic group. What does this finding mean? Finally When is enough surgery enough? What do you think? Dr. Jay Wellons from Vanderbilt comments on these questions and presented his group's approach to brain stem tumors. Challenging Case with experiments of Nature. What do they mean? 50 minutes with Discussion. (JIA)

SUMMARY: Dr. Jay Wellons from Vanderbilt University Medical Center discusses his years of experience with Pediatric Posterior Fossa Tumors. He reviews their International Program in Teaching Neurosurgery. He discusses his experience using pre-op ventricular drainage as benefitting the patient clinically and reducing the need for shunting post op from 70% to 12%. His general principle is to do what you can with compete resections leading to cure in Ependymomas, Pilocytic, and Low Grade tumors; He talks about the different subtypes of Medulloblastomas (WNT, SHH, Group 3 and 4) which have different outcomes; so if possible that typing should be done. They have developed "Cheat Sheet" which summarizes the outcomes and the subgroups of tumors (Included in the references-take a screen shot). The Discussion includes the world experience in treating these tumors. Excellent Summary. (50 minutes) (JIA)

SUMMARY: Dr. Blaylock reviews the importance of Vitamin D on human health. On hour exposure to the Sun produces 20,000 units of Vitamin D in the skin/day, far more than needed. The warnings about melanoma are exaggerated as Vitamin D, through the RAS gene, retards cell growth and division. Those with adequate intake of Vitamin D have same risk of melanoma as the unaffected population. Shielding from the Sun leaves the individual responsible for adequate Vitamin D oral intake which is not achieved. So large numbers of people are Vitamin D deficient. Deficiency leads to cancers (prostate, others) higher infection rate as the Vitamin D-protein complex in the blood has anti-inflammatory and antibiotic properties. Deficiency is common. Government prescribed levels are just a little above those which produce brain damage and dementia, 3-4X lower than necessary. Vitamin D is involved in the reactions of most of the 37 trillion cells in the body and significant segments of the population are deficient. A recent report from Australia found that 25%of the population was deficient in the winter and 15 % in the summer. Most children are deficient as Dr. Blaylock will describe. The deficiency is easily solved by oral supplementation and attention to blood levels regularly. Another unrecognized metabolic disease affecting the CNS, among others Dr..Blaylock has and will discuss and most will not recognize.  Does your Medical Clearance doctor know this information? Are you operating on A Vitamin D deficient patient?  Is it OK to just know Neurosurgery?  40 minutes of Discussion and Presentation. (JIA)

SUMMARY: Dr. Raphael Tamargo reviews the treatment of Intracranial aneurysms by endovascular vs surgical approaches. After surveying the literature for the last 30 years he finds that endovascular approaches have a 20% retreatment rate in 10 years and more with extended time vs 3% with surgical clipping. The retreatment rates for endovascular approaches is astounding and changes the perspective of treatment with endovascular approaches. With Drs. Eric Nussbaum and James Ausman as co-commentators, the three neurosurgeons have 150 years of combined experience in aneurysm treatment. In the LMIC endovascular approaches are too costly and surgical approaches are used as popularized by Hernesniemi. (See his aneurysm surgery videos on SNI and SNI Digital®) The heavy influence of the biomedical industry in this area is noted. The facts do not support this treatment except for aneurysms in special locations they discuss. Training of young neurosurgeons who can become skilled in this surgery is warranted. (70 minutes Discussion) Informative, controversial, factual. (JIA)