Spotlight on Antibodies

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in September, we'll highlight how experimental data supports AI-guided antibody discovery, how antibody-oligonucleotide conjugates deliver gene-regulating therapies, and how messenger RNA can enable antibody production inside the body.

References:

1. https://www.sciencedirect.com/science/article/pii/S2352304226003740
2. https://www.williamblair.com/-/media/downloads/eqr/2026/williamblair_from-code-to-clinic-how-ai-is-and-isnt-rewriting-the-life-of-a-drug.pdf
3. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002116
4. https://www.sciencedirect.com/science/article/pii/S0928098725002908
5. https://link.springer.com/article/10.1186/s13045-026-01824-4
6. https://www.mdpi.com/2077-0383/10/4/838
7. https://www.nejm.org/doi/abs/10.1056/NEJMoa2407326
8. https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(26)00044-2
9. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1494206/full
10. https://link.springer.com/article/10.1007/s12026-025-09737-z

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in August, we'll talk about engineering peptides into antibodies, the ADC therapeutic window, and targeting autoimmune memory.

References:

1. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.70430
2. https://pmc.ncbi.nlm.nih.gov/articles/PMC9913659/
3. https://ascopubs.org/doi/10.1200/EDBK-25-473916
4. https://pmc.ncbi.nlm.nih.gov/articles/PMC12171081/
5. https://pmc.ncbi.nlm.nih.gov/articles/PMC11860616/
6. https://argenx.com/news/2026/press-release-3333257
7. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1634090/full

Spotlight on Antibodies is a podcast from ⁠⁠Biointron⁠, where we bring you the latest antibody industry trends. This month from July, we'll highlight antibodies for IVD applications, the druggable proteome, and degrader-antibody conjugates.

References:

1. https://finance.yahoo.com/healthcare/articles/ivd-raw-materials-market-report-093700548.html
2. https://onlinelibrary.wiley.com/doi/full/10.1002/VIW.20240017
3. https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(26)00477-6
4. https://www.nature.com/articles/s41392-023-01589-z
5. https://pmc.ncbi.nlm.nih.gov/articles/PMC13292028/
6. https://www.nature.com/articles/s41571-023-00850-2
7. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1516419/full

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in June, we'll highlight the era of AI-driven antibody discovery.

References:

1. https://finance.yahoo.com/sectors/healthcare/articles/ai-antibody-discovery-market-research-080100551.html
2. https://pmc.ncbi.nlm.nih.gov/articles/PMC12298131/#B9-pharmaceuticals-18-00981
3. https://www.biospace.com/press-releases/pharmaceutical-cro-cdmo-market-forecast-from-usd-254-65-bn-to-usd-594-07-bn-by-2035
4. https://www.frontiersin.org/journals/drug-discovery/articles/10.3389/fddsv.2024.1339697/full
5. https://www.sciencedirect.com/science/article/pii/S0959440X26000540
6. https://www.sciencedirect.com/science/article/abs/pii/S0959440X25001022

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in May, we'll highlight the future of VHH technology, chemical conjugation in antibody therapeutics, and emerging trends in antibody characterization.

References:

1. https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2516676
2. https://academic.oup.com/peds/article/doi/10.1093/protein/gzaf010/8262225
3. https://academic.oup.com/bioinformaticsadvances/article/4/1/vbae033/7623636
4. https://www.nature.com/articles/s42003-026-09594-y
5. https://pubs.acs.org/doi/10.1021/polymscitech.5c00080
6. https://pmc.ncbi.nlm.nih.gov/articles/PMC12203927/
7. https://link.springer.com/article/10.1186/s11671-025-04200-2
8. https://pubs.acs.org/doi/full/10.1021/acs.bioconjchem.3c00040
9. https://www.nature.com/articles/s41598-023-43431-0
10. https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(26)00116-5
11. https://www.mdpi.com/1424-8247/16/2/291

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month, in April, we'll highlight ATP-dependent switch antibodies, the throughput-quality gap in antibody discovery, and multiple myeloma antibody treatments.

References:   

1. https://link.springer.com/article/10.1007/s40259-025-00752-y
2. https://www.sciencedirect.com/science/article/pii/S221112472031531X
3. https://link.springer.com/article/10.1208/s12248-026-01238-7
4. https://www.annalsofoncology.org/article/S0923-7534(25)03071-6/fulltext
5. https://aacrjournals.org/cancerdiscovery/article/11/1/158/2793/Antibody-to-CD137-Activated-by-Extracellular
6. https://link.springer.com/article/10.1208/s12248-026-01238-7
7. https://jitc.bmj.com/content/14/1/e013397
8. https://link.springer.com/article/10.1007/s40200-024-01386-7
9. https://link.springer.com/article/10.1186/s13036-025-00513-z
10. https://academic.oup.com/abt/article/6/1/13/6823522
11. https://www.clinical-lymphoma-myeloma-leukemia.com/article/S2152-2650(24)02423-6/fulltext

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in March, we'll highlight antibody allostery, trends in developability, and anti-IgE therapeutics. 

References:

1. https://www.sciencedirect.com/science/article/abs/pii/S0734975024001769
2. https://www.tandfonline.com/doi/full/10.1080/19420862.2017.1367074#abstract
3. https://www.mdpi.com/2304-8158/14/8/1360
4. https://www.sciencedirect.com/science/article/pii/S002228362500381X
5. https://www.nature.com/articles/s41467-025-65666-3
6. https://www.tandfonline.com/doi/full/10.1080/19420862.2023.2185924#abstract
7. https://www.fiercebiotech.com/sponsored/why-early-developability-assessment-strategic-necessity-modern-antibody-discovery
8. https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2562999
9. https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2593055%4010.1080/tfocoll.2023.0.issue-biologics-developability
10. https://www.tandfonline.com/doi/full/10.1080/19420862.2026.2627669
11. https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2026.1759921/full
12. https://www.biospace.com/press-releases/poplar-therapeutics-closes-45-million-series-a-extension-to-advance-development-of-lead-program-phb-050-a-new-class-of-anti-ige-therapy-for-multiple-atopic-conditions
13. https://excellergy.com/excellergy-to-be-acquired-by-novartis-for-up-to-usd-2-billion-to-advance-potentially-first-in-class-trifunctional-effector-cell-response-inhibitors/

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in February, we'll highlight radioantibodies, antibody-cytokine fusion proteins, and conditionally active antibodies.

References:

1. https://www.mdpi.com/2072-6694/17/21/3412
2. https://www.sciencedirect.com/science/article/abs/pii/S0001299896800201?via%3Dihub
3. https://swissrockets.com/news/swiss-rockets-group-alloy-therapeutics-partner-to-advance-radioligand-therapeutics-in-oncology
4. https://www.northstarnm.com/convergent-therapeutics-and-northstar-medical-radioisotopes-announce-expanded-partnership-to-support-convergents-late-stage-alpha-emitting-radioantibody-program/
5. https://www.businesswire.com/news/home/20250612596008/en/Debiopharm-and-Alkyon-Therapeutics-Announce-Research-Collaboration-to-Advance-the-Next-Generation-of-Radioligand-Therapies
6. https://pmc.ncbi.nlm.nih.gov/articles/PMC6994257/
7. https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2590250
8. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1498697/full
9. https://www.sciencedirect.com/science/article/pii/S0305737225000593
10. https://jitc.bmj.com/content/13/4/e010566
11. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1640427/full
12. https://www.sciencedirect.com/science/article/pii/S2468294224000170?via%3Dihub
13. https://ascopubs.org/doi/10.1200/JCO.2025.43.16_suppl.3077
14. https://pubs.acs.org/doi/10.1021/jacs.5c16108

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in January, we'll do a deep dive into last year's novel antibody drugs, G protein-coupled receptors, and fusion proteins.

References:

1. https://www.biointron.com/antibody-industry-trends/q4-2025-biointron-antibody-industry-insights-report.html
2. https://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147(25)00284-6
3. https://firstwordpharma.com/story/7047344
4. https://www.tandfonline.com/doi/10.1080/17460441.2023.2193389
5. https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.1061
6. https://linkinghub.elsevier.com/retrieve/pii/S0165614721001899
7. https://academic.oup.com/jimmunol/article/214/3/565/8052974
8. https://www.nature.com/articles/s44386-025-00015-4
9. https://doi.org/10.3389/fimmu.2025.1498697
10. https://www.sciencedirect.com/science/article/pii/S2950588725000060

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This December, we'll highlight the antibody startup ecosystem, microfluidic strategies driving next-generation antibody discovery, and the landscape of psoriasis treatment.

References:

1. https://www.mdpi.com/2079-6374/15/7/409
2. https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2597610?src=
3. https://www.nature.com/articles/s41587-024-02346-5
4. https://pubs.rsc.org/en/content/articlehtml/2025/lc/d5lc00340g
5. https://www.sciencedirect.com/science/article/pii/S2667237524003242
6. https://www.nature.com/articles/s41551-025-01411-x
7. https://pmc.ncbi.nlm.nih.gov/articles/PMC11417777/
8. https://www.prnewswire.com/news-releases/chinas-first-domestic-il-23p19-monoclonal-antibody-innovents-pecondle-picankibart-injection-received-nmpa-approval-302627980.html
9. https://www.nature.com/articles/d41586-025-02649-w
10. https://www.mdpi.com/1422-0067/26/19/9616