Spotlight on Antibodies

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This November, we'll highlight how non-canonical antibodies are reshaping immunotherapy, combination antibody therapies, and T cell exhaustion.

References:

1. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1723343/full
2. https://www.tandfonline.com/doi/10.1080/19420862.2025.2583210#abstract
3. https://www.cancertreatmentreviews.com/article/S0305-7372(15)00193-0/abstract
4. https://link.springer.com/article/10.1186/s13045-023-01509-2
5. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1556245/full
6. https://link.springer.com/article/10.1186/s12879-025-11012-3
7. https://www.sciencedirect.com/science/article/pii/S2274580724005934
8. https://onlinelibrary.wiley.com/doi/10.1002/ctm2.70345
9. https://www.pnas.org/doi/10.1073/pnas.2409564122
10. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1507501/full
11. https://www.nature.com/articles/s41577-019-0221-9
12. https://www.sciencedirect.com/science/article/pii/S1074761325003711

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This October, we'll highlight advances in antibody design with AI, crossing the BBB, and universal antibodies. 

References:

1. https://biomarkerres.biomedcentral.com/articles/10.1186/s40364-025-00764-4
2. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1637602/full
3. https://pubs.acs.org/doi/10.1021/acs.bioconjchem.5c00379
4. https://www.nature.com/articles/s41467-025-59447-1
5. https://www.sciencedirect.com/science/article/pii/S0165614725001828
6. https://pmc.ncbi.nlm.nih.gov/articles/PMC12306175/
7. https://pubs.acs.org/doi/10.1021/acsami.4c18679
8. https://www.nature.com/articles/s41590-025-02286-5
9. https://www.science.org/doi/10.1126/sciadv.adx3505
10. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00481-5/abstract
11. https://pubs.acs.org/doi/10.1021/acsnano.5c08128
12. https://www.cell.com/cell/fulltext/S0092-8674(25)01032-3

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This September we'll highlight recent approvals in biosimilar drugs, conjugate linker designs, and discovery platform advances.

References

1. https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-025-00693-9
2. https://pmc.ncbi.nlm.nih.gov/articles/PMC12185665/
3. https://www.prnewswire.com/news-releases/professor-sarfaraz-k-niazi-secures-first-ever-fda-acceptance-to-waive-clinical-efficacy-studies-for-monoclonal-antibody-biosimilars-302542781.html
4. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202500262
5. https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c01500
6. https://www.sciencedirect.com/org/science/article/pii/S1520480424010044
7. https://www.nature.com/articles/s41598-025-13810-w
8. https://www.mdpi.com/1424-8247/18/8/1198
9. https://jbioleng.biomedcentral.com/articles/10.1186/s13036-025-00513-z
10. https://news.illinois.edu/high-volume-antibody-testing-platform-could-accelerate-disease-research-and-treatment-development/
11. https://pmc.ncbi.nlm.nih.gov/articles/PMC11623700/
12. https://pubs.rsc.org/en/content/articlehtml/2025/lc/d5lc00340g

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This August, we highlight drug advances in autoimmune and infectious diseases, as well as next-generation immune cell engagers.

References:

1. Pelkas, C., Franke, K. B., Vincent, F. B., & Rischmueller, M. (2025). Novel therapies in Sjögren’s disease: A systematic review of the literature. Best Practice & Research Clinical Rheumatology, 102084. https://doi.org/10.1016/j.berh.2025.102084
2. Subramaniam, S., Saville, J. W., Feng, F., & Freiburger, L. (2025). Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future. Biochemistry. https://doi.org/10.1021/acs.biochem.5c00192
3. Atanasov, P. Y., Moneva-Sakelarieva, M. G., Kobakova, Y. A., Ivanova, S. A., Becheva, M. V., Kirkova-Bogdanova, A. G., Chaneva, M. S., Atanasova, V. P., Todorov, R. F., Bashev, N. Z., Bashov, I. E., & Ibrahim, A. H. (2025). Monoclonal antibodies: their place in applied medicine and their role in the newest infectious disease – history, present, and future. Literature review. Pharmacia, 72, 1–18. https://doi.org/10.3897/pharmacia.72.e159772
4. Fucà, G., Spagnoletti, A., Ambrosini, M., De Braud, F., & Di Nicola, M. (2021). Immune cell engagers in solid tumors: Promises and challenges of the next generation immunotherapy. ESMO Open, 6(1), 100046. https://doi.org/10.1016/j.esmoop.2020.100046
5. In, H., Park, M., Lee, H., & Han, K. H. (2025). Immune Cell Engagers: Advancing Precision Immunotherapy for Cancer Treatment. Antibodies, 14(1), 16. https://doi.org/10.3390/antib14010016
6. Albayrak, G., Wan, P. K., Fisher, K., & Seymour, L. W. (2025). T cell engagers: Expanding horizons in oncology and beyond. British Journal of Cancer, 1-9. https://doi.org/10.1038/s41416-025-03125-y‌

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This July, recent research includes computational tools for nanodiscs, antibody-drug conjugate (ADC) development, and antibody-antigen research.

References:

1. Yao, X., & Thomson, C. A. (2025). Review: Membrane protein nanodiscs for antibody discovery. Current Opinion in Structural Biology, 94, 103104. https://doi.org/10.1016/j.sbi.2025.103104
2. Baskakova, K. O., Kuzmichev, P. K., & Karbyshev, M. S. (2024). Advanced applications of Nanodiscs-based platforms for antibodies discovery. Biophysical Chemistry, 313, 107290. https://doi.org/10.1016/j.bpc.2024.107290
3. Dong, Y., Tang, H., Dai, H., Zhao, H., & Wang, J. (2024). The application of nanodiscs in membrane protein drug discovery & development and drug delivery. Frontiers in Chemistry, 12, 1444801. https://doi.org/10.3389/fchem.2024.1444801
4. Kuai, R., Yuan, W., Son, S., Nam, J., Xu, Y., Fan, Y., Schwendeman, A., & Moon, J. J. (2018). Elimination of established tumors with nanodisc-based combination chemoimmunotherapy. Science Advances. https://doi.org/aao1736
5. Noriega, H. A., & Wang, X. S. (2025). AI-driven innovation in antibody-drug conjugate design. Frontiers in Drug Discovery, 5, 1628789. https://doi.org/10.3389/fddsv.2025.1628789
6. Croitoru, A., Orr, A. A., & MacKerell, A. D. (2025). Harnessing computational technologies to facilitate antibody–drug conjugate development. Nature Chemical Biology, 21(8), 1138-1147. https://doi.org/10.1038/s41589-025-01950-z
7. Chen, L., Li, B., Chen, Y., Lin, M., Zhang, S., Li, C., Pang, Y., & Wang, L. (2025). ADCNet: A unified framework for predicting the activity of antibody-drug conjugates. Briefings in Bioinformatics, 26(3). https://doi.org/10.1093/bib/bbaf228
8. Su, A., Luo, Y., Zhang, C., & Duan, H. (2025). Linker-GPT: Design of Antibody-drug conjugates linkers with molecular generators and reinforcement learning. Scientific Reports, 15(1), 1-15. https://doi.org/10.1038/s41598-025-05555-3
9. Sato, K., Uehara, S., Tsugita, A., Ishii, M., Ishiyama, S., Maejima, A., Nakahara, I., Nazuka, M., Matsui, T., Christos, G., Yokoyama, T., Kumagai, I., Makabe, K., Asano, R., & Tanaka, Y. (2025). Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement. Cell reports, 44(7), 115965. https://doi.org/10.1016/j.celrep.2025.115965
10. Myung, Y., Pires, D. E., & Ascher, D. B. (2023). Understanding the complementarity and plasticity of antibody–antigen interfaces. Bioinformatics, 39(7). https://doi.org/10.1093/bioinformatics/btad392
11. Heirene, L., Byrne, H., Sepp, A., Gaffney, E., & Yates, J. (2025). Understanding antibody-target antigen interactions and the avidity effect using mathematical modelling. Journal of the Royal Society, Interface, 22(228), 20240710. https://doi.org/10.1098/rsif.2024.0710
12. Torrents de la Peña, A., Sewall, L. M., de Paiva Froes Rocha, R., Jackson, A. M., Pratap, P. P., Bangaru, S., Cottrell, C. A., Mohanty, S., Shaw, A. C., & Ward, A. B. (2023). Increasing sensitivity of antibody-antigen interactions using photo-cross-linking. Cell reports methods, 3(6), 100509. https://doi.org/10.1016/j.crmeth.2023.100509
13. Manion, A., Brooks, T. M., & Brooks, C. L. (2025). Antibody-Antigen Epitope Mapping by X-Ray Crystallography. Methods in molecular biology (Clifton, N.J.), 2937, 15–31. https://doi.org/10.1007/978-1-0716-4591-8_2

Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This June, recent research includes VHH antibodies, antibody-drug conjugates in oncology, and antibody engineering as a countermeasure to drug resistance.

Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This May, top news includes BCMA-Targeted Therapies, Multifunctional (Natural Killer Cell Engagers), and Engineering IgE Antibodies.

Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This April, top news includes Fc engineering, FcRn inhibitors, and Tregitopes.

Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This March, top news includes ion channel and GPCR-driven diseases, affinity maturation, and a look back at SARS-CoV-2, 5 years on.

Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This February, top news includes novel antibodies to treat obesity, hereditary angioedema, and B cells.