In this episode of the Nucleate Podcast, Armand Cognetta, founder and CEO of General Proximity, shares his compelling journey from a directionless college student to a biotech entrepreneur. Drawing from personal experiences of academic struggles and scientific curiosity, Armand discusses how his passion for chemical biology and small molecule drug discovery led him to create a groundbreaking proximity therapeutics platform. He candidly explores the challenges of startup life, including early fundraising difficulties, imposter syndrome, and the critical importance of persistence, grit, and maintaining a high bar for talent. Throughout the conversation, Armand emphasizes the value of working on ambitious, world-changing ideas, the power of proximity in biological systems, and the need for founders to stay focused, resilient, and mission-driven. His story is a testament to the transformative potential of scientific innovation and entrepreneurial spirit, offering inspiration for young scientists and aspiring founders navigating the complex landscape of biotech startups.

Time Stamps

00:00 – Intro 

03:12 – Growing up in northern Florida 

06:44 – Taking a year off college due to poor grades 

07:05 – A transformative internship experience 

08:33 – Paul Graham’s blog & early obsession with tech 

11:25 – Learning persistence through failure 

20:06 – How to generate and evaluate startup ideas 

36:02 – What is General Proximity? 

53:15 – Impostor syndrome & early founder struggles 

1:02:00 – How past failures prepared him 

1:05:53 – Recruiting and retaining talent in startups 

1:09:57 – Biotech vs. tech: hiring challenges 

1:16:28 – Building an effective advisory board 

1:19:46 – Advice for aspiring founder-scientists 

1:22:00 – Final thoughts on entrepreneurship & ambition