🧠 Six landmark stroke investigations published in NEJM, JAMA, and Lancet are redefining modern reperfusion science.

🔹 ORIENTAL-MeVO: Thrombectomy improved outcomes in selected medium-vessel occlusion strokes. 🔹 TNK-PLUS: Bridging tenecteplase before EVT in the late window showed no added benefit. 🔹 CHOICE-2: Intra-arterial alteplase after successful thrombectomy improved excellent recovery but raised mortality concerns. 🔹 INSTANT: Early tirofiban after inadequate tenecteplase response improved 90-day outcomes. 🔹 TAPIS: Early ticagrelor + aspirin after thrombolysis improved functional recovery without excess major bleeding. 🔹 ATLAS: EVT benefited large-core stroke patients up to 24 hours after onset.

Together, these studies shift the conversation from simply reopening arteries toward optimizing tissue-level reperfusion, patient selection, and microvascular recovery. 🚑⚡

#Stroke #Neurology #Thrombectomy #JAMA #NEJM #Lancet #Neurointervention #Tenecteplase #Tirofiban #Cardiology