Dr. Chloe West breaks down the real difference between 5-MeO-DMT and ayahuasca. 5-MeO shuts the default mode network completely off and back on like a computer reboot, while ayahuasca never turns off, it just takes you deeper into what she calls the multiverse. She recommends starting with more grounded medicines like Ibogaine, mushrooms, or San Pedro before working up to ayahuasca, and explains why psychedelics essentially wipe preconceived predictions in the brain, letting people experience the world with childlike eyes again. She also opens up about her own path into this work, sparked by an ayahuasca documentary she watched at age 10, and previews her upcoming book interviewing people ages 25 to 70 about religious trauma and how psychedelics have helped them process harmful beliefs instilled by high control religious environments.

Dr. Chloe West studies the neuroscience of psychedelics and religious trauma. Her research found that psychedelics alter how the brain processes information for up to 30 days after a trip ends, using an oddball paradigm with EEG data and psilocybin studies in mice to measure exactly how predictive processing breaks down. She breaks down why mystical experiences on psychedelics are measurably stronger than those from prayer or near death experiences, the theory that Moses' burning bush may have been an ayahuasca-containing plant, her own path leaving a fundamentalist megachurch, and her current book project studying how people raised in high control religious environments use psychedelics to process religious trauma and reshape their relationship with God. Also covered, the difference between 5-MeO-DMT and ayahuasca, panpsychism versus materialism, and why integration matters as much as the trip itself.

Miki Agrawal built THINX Tushy and Hero by fixing the bodily functions nobody wants to talk about periods, bathroom habits, and diapers that take 400 to 500 years to break down. She breaks down the three questions she asks before starting any business, the zero dollar marketing stunts that built her brands including Buttcon and a literal funeral for a tree, the SNL rant that put Tushy on the map overnight, surviving 9/11 by sleeping through her alarm, the eerie children's book moment that sparked the idea for Hero, her Ibogaine journey and the year of integration that followed, and why she launched Hero with a prayer instead of a traditional strategy.FOLLOW FOR MORE!

Three years into podcasting Brent and Tony break down everything they wish someone had told them before they started. Why chasing the best equipment is a trap. Why audio quality matters more than video. Why 70 percent of podcasts never make it past episode 7 and 98 percent never make it past episode 20. How to figure out if you should focus on guests or solo episodes based on your actual goal. Why podcasting is one of the worst businesses to get into if money is the only reason you are doing it, and the one exception that changes everything if you already have a business. Plus a first look at TFG Studios, their new content production arm for brands.FOLLOW FOR MORE!

Victor Varnado moved to New York in 1997. By 1999 he was in End of Days with Arnold Schwarzenegger and The Adventures of Pluto Nash with Eddie Murphy. Then he walked away from that path because Hollywood only wanted him playing the same type of role. Since then he has written for Marvel and Vice, produced television, done stand-up as King Supernuts, and built a business called High Score Game Arcade, a B2B video game publisher creating custom games for brands. His current project is the Worldwide Tic-Tac-Toe Championship, a live gamified broadcast system he patented 30 minutes before this interview, designed in part to identify high fluid intelligence through simple tic-tac-toe strategy. Plus mushroom stories at Eric Andre's birthday party, the master plan for world domination, and why he thinks video games are no different from a great novel.

Brent and Tony answer your questions in this Q&A episode covering how festivals have changed as they got older, their most challenging psychedelic trips, and the wildest stories from over a decade of festival culture. Tony's DMT tree ceremony that made his friends think he was dying. Brent's Owlsley acid trip where his partner's shaky hands turned one hit into four, sending him into an eight hour reality snap complete with imaginary spiders and a tent that looked like alien technology. This is the raw unfiltered side of psychedelics that nobody talks about.

In the age of AI the people who stand out online are not the most polished. They are the most alive. Lola Love is a personal brand and visibility strategist with 11 years and 400 plus clients and her answer to standing out in an AI dominated world is simple — be ridiculously human raw and real. Her second ever viral post was a carousel of her and two girlfriends covered in mud on a beach in Hawaii. That was not a strategy. That was her highest joy. And that is exactly the point. She also opens up about getting cyberbullied in Bali into crippling shame that shut down her entire business, how tantra helped her alchemize it, coming back with a rap and a fire she did not have before, moving to Austin and rebuilding from nothing, and why she is now co-creating her own raspberry rose cacao flavor with Holy Wow Cacao. Plus the bath cast. Plus positive pranks. Plus what actually makes someone go viral.

Kristin Weitzel has spent over a decade in breathwork cold exposure and nervous system regulation working with MMA fighters Olympic skaters championship swim teams and Ariana Grande's world tour dancers. In this episode she breaks down whether women should actually be cold plunging the exact breathing protocols that separate winners from runners up and the story of how she went from launching Red Bull in America to becoming what her mentor called a medicine woman. She also talks about why integration work matters more than how many times you've done ayahuasca and shares the car accident story where one exhale may have saved her life.

Most candy leaves a residue in your mouth that makes you feel like you did something wrong. These two founders decided that was insane. Ben Hindman and Savannah Wolfe built LELICK — electrolyte lollipops made with organic honey potassium magnesium and zero dyes. No shortcuts no cheap marketing no sexual innuendos. Just a genuinely good product that started with a high idea at a Skrillex concert landed after 30 plus formula iterations and now has strangers buying subscriptions six weeks after launch. They talk about the origin story the manufacturing nightmare the team running on pure equity and why the candy industry is basically a poison factory that nobody has bothered to fix yet.

Automation without security is dangerous. Security without automation is exhausting. Jordan Mayer is the founder of Mayday Cyber and Naptic and he built both companies from a travel trailer with Starlink because nobody else was combining deep cybersecurity with agentic AI systems. In this episode he breaks down why ADHD and neurodivergent people will thrive in the AI era why zero day vulnerabilities are more terrifying than ever why Mythos keeps him both excited and awake at night and why every small business that is not thinking about security while they automate is leaving the front door wide open for someone who is.