Welcome back to The Caring Neurologist! In this milestone 10th episode, “The Future of Genetic Therapy in Movement Disorders,”  the ever-insightful Dr. Sandeep Thakkar unravels the science and hope behind gene therapy for Parkinson’s disease and beyond. They break down what gene therapy really means, going beyond the headlines and “science fiction” buzzwords like CRISPR to explain how this groundbreaking approach aims to address the very root causes of movement disorders.

Dr. Thakkar shares the latest updates on clinical trials for therapies targeting genetic mutations like GBA1, and discusses how viral delivery systems and gene editing are shaping the next wave of Parkinson’s treatments. The conversation moves from technical breakthroughs to bigger questions about safety, personalized medicine, real-world challenges, and the immense hope these advances offer for patients and families.

Whether you’re living with Parkinson’s, care for someone who is, or are just fascinated by the future of medicine, this episode will leave you feeling both grounded and inspired. Stay tuned for an episode that’s as informative as it is hopeful!

00:00 Gene Therapy Advances

03:28 Gene Therapy for Parkinson's

07:24 Gene Editing: CRISPR Explored

12:43 GBA1 Mutation in Parkinson's Disease

16:15 Gene Therapy: A Parkinson's Update

17:09 Revolutionizing Care in Neurology

21:26 Gene Therapy Advancements in Huntington's Disease

26:17 Gene Therapy Delivery Challenges

29:43 Genetic Insights in Parkinson's Prevention

33:23 Understanding Future Changes in Gene Therapy

36:16 Balance Excitement and Challenges

37:37 Ozzy Osbourne's Impactful Legacy

The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/

Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/

Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/

TopHealth - https://tophealth.care/

Welcome to another episode of The Caring Neurologist! In today’s insightful conversation, Dr. Sandeep Thakkar's talks about what Diet and Toxins Reveal About Brain Health. As one of the most-heard video podcasts in neurology, this episode tackles the crucial, and often misunderstood links between nutrition, environmental toxins, and brain health, especially for those living with Parkinson’s and movement disorders.

Dr. Thakkar explores how what we eat truly acts as medicine for the mind, breaking down the science behind everyday foods, healthy eating patterns, and why your grocery list matters more than ever. They discuss the impact of processed foods, why the “Mediterranean” and “MIND” diets win out, and offer practical advice for anyone feeling overwhelmed by conflicting dietary guidance and environmental health news. Whether you’re looking for clear advice on what to eat, how to minimize exposure to harmful substances, or realistic steps to improve your nutrition, this episode serves as a friendly guide to boosting your brain’s health one bite at a time.

Grab your favorite snack (just maybe skip the breakfast pizza), and join us for a relatable, evidence-based conversation designed to empower you on your journey to better brain health!

00:00 "Food as Fuel and Medicine"

05:00 Supporting Brain Health with Nutrition

08:39 Small Changes for Lasting Success

12:39 "Foods Harmful to Brain Health"

16:29 Pesticides, Farming, and Parkinson's Link

19:23 Water Contamination Awareness & Action

23:22 Choosing Clean Over Costly Organic

26:36 Consistent Healthy Eating Mindset

29:53 Sweets Worsen Parkinson's Symptoms

32:26 Enhanced Food Label Clarity

36:52 "Boost Health with Habits"

38:27 Artificial Sweeteners and Health Concerns

The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/

Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/

Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/

TopHealth - https://tophealth.care/

Welcome to the eighth episode of The Caring Neurologist with Dr. Sandeep Thakar! In this thought-provoking conversation, Dr. Thakkar dives into the alarming links between Parkinson’s disease and environmental toxins, specifically the pesticides used at golf courses and in our own backyards. Inspired by a recent JAMA Neurology study, they unravel how living near manicured greens could impact long-term brain health, what specific chemicals are involved, and why these risks matter far beyond just golfers. Together, they answer pressing questions about real-life risk, discuss practical steps you can take to protect yourself and your loved ones, and challenge us all to advocate for stronger public health measures, without giving in to panic. Whether you’re a concerned parent, a public health enthusiast, or just curious about what’s really in your water, this episode will empower you with knowledge and leave you with actionable advice. Tune in to find out what might be hiding in your backyard, and what you can do about it.

00:00 Golf Course Proximity and Parkinson's Risk

04:25 Golf Course Pesticide Safety Concerns

08:30 Pesticides Cause Nervous System Damage

10:44 Pesticide Exposure and Brain Damage

15:47 Mindful Awareness of Water Safety

17:52 Environmental Safety Concerns in Golf Courses

20:22 "Concerns Over Industrial Farming Practices"

26:06 Diet, Chemicals, and Antibiotic Concerns

29:13 "Evaluating Food Safety and Diets"

31:16 Air and Car Pollution Concerns

The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/

Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/

Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/

TopHealth - https://tophealth.care/

Welcome to episode seven of The Caring Neurologist, where hosts Dr. Sandeep Thakkar dives deep into the world of Parkinson’s disease, this time shining a spotlight on the cutting edge of clinical research. In this episode, Dr. Thakkar explains why research and care are inseparable for truly advancing Parkinson’s treatment, and opens up about the most exciting developments shaping the field today.

From discussing the importance and process of clinical trials, to breaking down how gene therapy, artificial intelligence, and novel therapies like stem cells are transforming what’s possible for Parkinson’s patients, this conversation is packed with hope and real-world insights. Dr. Thakkar shares his unique perspective as both a hands-on physician and research leader, offering a glimpse into promising new studies and explaining how patients can get involved in shaping the future of care.

If you or a loved one are navigating Parkinson’s or just curious about how research becomes real-life treatment breakthroughs, this episode is filled with practical wisdom, encouragement, and a peek at the innovations on the horizon. So grab your notebook and get ready to be inspired by Dr. Thakkar’s passion and expertise, as he remind us why curiosity, partnership, and patient empowerment are the driving forces behind progress.

Timestamps:

00:00 FDA Clinical Trial Phases

07:20 Advancements in Parkinson's Research

09:49 AI in Pharma: Molecular Insights

12:48 Parkinson's Research Developments

17:50 Parkinson’s as a Proteinopathy

20:53 Clinical Trial Participation Considerations

25:55 Pharma Influence on Politics

29:46 Parkinson’s Care and Research Hub

32:05 Purpose-Driven Career

34:16 Recording End Acknowledgment

The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/

Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/

Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/

TopHealth - https://tophealth.care/

Welcome to episode six of The Caring Neurologist! In this episode, Dr. Sandeep Thakkar dives deep into a truly life-changing topic: Deep Brain Stimulation (DBS). While the phrase might sound futuristic or even a little intimidating, DBS is a reality for thousands of people living with Parkinson’s disease and other neurological conditions. Dr. Thakkar unpacks what DBS really is, how it works, and why it’s become such a promising treatment option for managing symptoms like tremor and stiffness when medications are no longer enough.

Dr. Thakkar shares his clinical experiences, the science behind DBS, who might be a candidate, and what patients can expect every step of the way - from evaluation through surgery to life after DBS. With patient stories, practical advice, and a look ahead at new advances like adaptive DBS, this episode sheds light on a therapy that is giving patients and families real hope and renewed quality of life.

If you’ve ever wondered what it’s like to consider or live with DBS, or just want to hear about some of the most exciting technology at the intersection of neurology and care, this episode is for you. Tune in to discover how science fiction is becoming science fact -and hear firsthand just how transformative advances in neurological care can be.

Timestamps:

00:00 Fulfillment in Evolving Medicine

04:15 Parkinson's Dopamine and Brain Stimulation

07:38 Brain Stimulation Device Programming

11:36 Optimal Timing for Deep Brain Stimulation

13:41 From Epilepsy to Movement: A Journey

16:30 Deep Brain Stimulation Process

21:29 Deep Brain Stimulation Overview

23:57 Early Intervention in Brain Surgery

26:58 Adjustable Facial Stimulation Therapy

31:44 Balancing Medication and Well-being

35:07 Choosing Parkinson's Care and Trials

38:14 Weighing DBS Surgery Risks

39:52 "Deep Brain Stimulation Insights"

43:19 Deep Brain Stimulation for Epilepsy

The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/

Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/

Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/

TopHealth - https://tophealth.care/

Welcome back to The Caring Neurologist, the podcast episode where renowned neurologist Dr. Sandeep Thakkar tackle common fears and misconceptions about Parkinson’s disease, all while sharing hopeful and practical advice for patients and families. In this episode, Dr. Thakkar dives deep into the myths that often surround Parkinson’s - clarifying that it’s not just about tremors, that it’s not a death sentence, and that the disease can look very different for each individual.

Dr. Thakkar discusses rarely recognized early symptoms like subtle changes in dexterity, slowness, and even gut issues such as constipation. They explore the realities behind genetic risks, when to seek a professional opinion, and the vital role lifestyle, exercise, and mindset play in living well with Parkinson’s. With vivid patient stories and straightforward answers, Dr. Thakkar highlights the power of empowerment, community, and staying active, no matter when or how a diagnosis arrives.

If you or a loved one are facing Parkinson’s or you’re simply curious about separating fact from fiction, this episode is full of clarity, encouragement, and actionable advice. Let’s join Dr. Thakkar to debunk the myths and highlight the real journey of living with Parkinson’s.

Timestamps:

00:00 Debunking Parkinson's Myths

05:28 Parkinson's Without Predominant Tremors

09:47 Parkinson's Genetic Risk Factors Study

13:32 Workplace Exposure Risks and Precautions

16:16 Understanding Presynaptic Disease and Levodopa

18:47 Unexpected Leukemia Diagnosis Shock

24:11 Exercise Caution: Avoid Injury

26:15 Parkinson's: Myths and Management

28:52 Managing Stress for Happiness

33:48 Genetic and Environmental Health Factors

36:11 Navigate Health Concerns Strategically

38:03 Balancing Assistance and Independence

The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/

Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/

Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/

TopHealth - https://tophealth.care/

Welcome back to another episode of The Caring Neurologist. In today’s deeply moving installment, host Dr. Sandeep Thakkar explores the often overlooked emotional and social challenges of living with Parkinson’s disease. While many people associate Parkinson’s primarily with tremors and movement difficulties, Dr. Thakkar shares his front-line experience treating the whole person—not just the symptoms—and highlights the profound impact this diagnosis has on patients and their families alike.

Dr. Thakkar dives into the vulnerability felt by those receiving a new diagnosis, the complex ways the disease can affect a person’s confidence and sense of identity, and the crucial role loved ones play in the journey. Real-life stories, from young adults navigating Parkinson’s in the prime of life to patients reclaiming joyful moments like running marathons or returning to beloved hobbies, bring hope and humanity to the conversation. Dr. Thakkar also offers insights for caregivers, advice on finding support, and a heartfelt reminder: no one has to face Parkinson’s alone.

Join us for an honest, compassionate discussion that will leave you inspired by the resilience of individuals and families facing Parkinson’s—and the power of a caring, team-based approach to neurological health.

Timestamps:

00:00 Physical and Mental Impact of Tremors

06:59 Understanding Patient Consults Beyond First Visit

08:14 Carefully Diagnosing Parkinson’s Disease

12:04 "Spouse Feedback on Sleep Patterns"

15:23 Early-Onset Parkinson's Connection

19:08 New Dopamine Therapy Success

23:24 Managing Symptoms to Improve Life

27:17 Realistic Expectations for New Therapies

29:02 Joy in Patient Recoveries

32:21 Balancing Emotional Strain and Self-Care

35:26 Balancing Caregiving and Personal Needs

The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/

Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/

Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/

TopHealth - https://tophealth.care/

Welcome back to another enlightening episode of The Caring Neurologist with your host, Dr. Sandeep Thakkar. Today, we're diving deep into a topic that extends far beyond the realm of cosmetic procedures — the medical marvel that is Botox. 

Many know Botox as a tool against wrinkles and fine lines, but Dr. Thakkar is here to explore its transformative power in treating movement disorders, particularly in patients with Parkinson's disease. From its origins to groundbreaking innovations, this episode unravels how Botox goes beyond beauty, offering hope and improved quality of life for many. 

Dr. Thakkar explores real patient stories, discuss the nuances of Botox in neurology, and envision a future where Botox continues to break boundaries in medical treatments. Whether you're familiar with Botox or new to its therapeutic potential, this episode promises to open your eyes to its profound impact.

Timestamps:

00:00 Botulinum Therapy in Medical Use

06:46 Bacterial Toxin Uses in Medicine

08:54 Botox Myths and Misunderstandings

12:43 Customized Botox Injection Techniques

16:11 Parkinson's Muscle Cramps and Mismanagement

18:56 Considering Deep Brain Stimulation Risks

22:58 Balancing Botox Benefits and Risks

26:45 Medical Advertising for Neurological Treatments

27:39 Parkinson's Patient Regains Driving Confidence

32:39 Enhancing Essential Tremor Treatment

34:37 "Expanding Access to Botox for Patients"

40:10 Botox: Symptom Management, Not Cure

42:14 Innovative Patient Care Discussion

The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/

Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/

Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/

TopHealth - https://tophealth.care/

In this enlightening episode of "The Caring Neurologist" Dr. Sandeep Thakkar dives deeply into the world of Parkinson's disease, tackling the complexity and misconceptions surrounding this neurodegenerative disorder. From breaking down the basics of what Parkinson's truly entails to exploring the wide array of movement disorders that often mimic its symptoms, this episode is packed with valuable insights. 

Dr. Thakkar shares his extensive knowledge, offering guidance on managing the disease and shedding light on the potential causes, such as genetic and environmental factors. The discussion also highlights the importance of a timely and accurate diagnosis, addressing the common misdiagnoses that can complicate treatment. As they navigate through the intricacies of Parkinson's, listeners will also find hope and encouragement in the stories of resilience and the advancements in therapies that aim to improve the quality of life for those affected. 

Join us for a conversation that demystifies Parkinson's and empowers individuals to take control of their neurological health.

Timestamps:

00:00 Understanding Parkinson's: Beyond Dopamine

05:10 Factors Influencing Parkinson's Risk

08:52 Drug-Induced Movement Disorders Explained

13:22 Admiration for a Philanthropic Icon

15:13 Potential Parkinson's Triggers Explored

18:47 Understanding Postural Instability and Dystonia

23:13 Sleep Movement Disorders and Parkinson’s

25:09 Parkinson's and Dopamine Mimics

27:12 Early Parkinson's Symptoms Identified

30:20 Parkinson's: Complex Neurotransmitter Degeneration

36:32 Medicine's Daily Rewards

38:02 "John Ball: Parkinson's Marathon Hero"

41:27 Parkinson's Education and Hope

The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/

Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/

Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/

TopHealth - https://tophealth.care/

Welcome to "The Caring Neurologist" where we dive into the fascinating world of neurology with the passionate Dr. Sandeep Thakkar. In this episode, we embark on the journey of Dr. Thakkar, from his early inspirations to his groundbreaking work in the field of movement disorders. 

Raised by his grandma and a mother who battled epilepsy, Dr. Thakkar developed a fervent desire to become a neurologist. After grappling with personal loss in medical school, he shifted his focus from epilepsy to Parkinson’s disease, making significant strides in treatment, including the innovative use of Botox for movement disorders. 

Join us as we explore his motivations, challenges, and aspirations to redefine patient care and make neurology more accessible. This conversation promises to enlighten and inspire as Dr. Thakkar shares his experiences, patient stories, and vision for the future of Parkinson's care. Grab your headphones and let's dive into the dynamic world of neurology!

Timestamps:

00:00 Childhood Amid Mother's Seizures

04:07 Pursuing Education in the U.S.

08:55 Journey Through Grief and Medical Passion

11:38 Finding Higher Purpose Through Loss

13:53 Therapy for Movement Disorders

17:59 Parkinson's: Handwriting and Spasms

21:29 Non-Drug Therapies for Tremors

23:59 Facing Parkinson's: Communication Challenges

26:48 Guiding Patients in Long-term Care

31:31 "Smart, Caring, Proactive Doctor"

34:44 Brain Multitasking and Parkinson's

37:24 Children Are Sponges, Adults Stressed

42:37 Improving Healthcare Access and Inclusion

43:55 Gratitude for Sharing Time

The Caring Neurologist - Podcast Website - https://thecaringneurologist.com/

Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/

Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/

TopHealth - https://tophealth.care/