It has been three years since the Progerians left their mark of devastation upon Earth. The remaining humans are in a desperate race against time as they do their best to reverse engineer the alien technology they captured, in an effort to bolster their beleaguered defenses against the oncoming onslaught of Progerians hell-bent on revenge. Revenge against the humans that thwarted their take-over and revenge against the subordinate Genogerians that helped.
Mike reunites with his wife and his friend, Paul, aboard the Guardian, only to find that things have gone from bleak to hellish on Earth. Rampaging hordes of Genogerians plague the planet, as does an invasion from Progerians hell-bent on knuckling under the will of man through their relentless assault. Yet this may not be the worst of it, as an insidious "ally" has lent their support. At what cost can a planet on the brink come back from such desperate odds?