Gennaro D'Urso is the founder of Pharma Collective and Israel Mirsky is the Director at Pharma Collective. Gennaro has a background in science and entrepreneurship, while Israel comes from the advertising industry and has experience in the pharmaceutical psychedelic space.

Gennaro and Isreal discuss the problems with big Pharma's business model, which focuses on new drug discovery rather than affordable medications that meet public health needs. They propose building an ecosystem to manufacture essential drugs or repurpose existing ones for broader use.

Gennaro discusses the mission of Pharma DAO, which is to develop affordable drugs and combat the monopoly of big pharma. By involving the community in identifying needs and participating in trials, Pharma DAO aims to establish a sustainable economic model through royalties received from for-profit companies. Israel highlights potential strategies such as repurposing off-patent drugs and supporting manufacturing to address drug shortages. Collaboration with small pharmaceutical companies is crucial, as they play a significant role in manufacturing essential medications. However, these smaller companies face challenges due to profit margins and outdated technologies. The goal is to create funding models that support projects between millions and hundreds of millions of dollars, filling the gap where traditional funding falls short. Licensing agreements rather than investments are pursued with for-profit companies, allowing Pharma DAO to receive royalties for self-sustainability. This model has been successful before with organizations like the Cystic Fibrosis Foundation.

They emphasize the importance of decentralization, community involvement, and equal voting rights. 

The next steps include a proper launch, raising awareness, setting up efficient mechanisms, and involving the community in decision-making. They believe that decentralized technologies can have a significant impact on public health and encourage people to join as members to make a difference.

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Jasper De Gooyer is the co-founder and CTO at SEDA, a multichain, permissionless protocol connecting real-world data to any network on-chain.

SEDA is a decentralized oracle network designed to bring data from the real world onto the blockchain. It is a multichain, permissionless protocol connecting real-world data to any network on-chain by enabling the integration of external data and events into smart contracts.

Jasper says the SEDA team made the conscious decision to build the 𝑒𝑣𝑒𝑟𝑦𝑡ℎ𝑖𝑛𝑔 𝑜𝑟𝑎𝑐𝑙𝑒. This is absolutely core to the design. It means that just as any user can interact with Ethereum to perform deterministic computation, any contract can interact with the Seda Protocol to perform deterministic computation on non-deterministic data.

SEDA has launched its first testnet, with mainnet coming in Q1, 2024.

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Tanya Petrusenko is the CEO at Bitmedia, a global crypto advertising platform that helps crypto companies find crypto users around the world.

Bitmedia started in 2014 to provide advertising opportunities for businesses in the emerging crypto space. Back then, there were few competitors, and most ads were on Bitcoin Talk. The goal was to connect crypto publishers with advertisers and enable monetization through ads.

Bitmedia has grown over the years and currently has around 120 team members. Despite challenges during bear markets when budgets are tight, they continue to attract advertisers preparing for future growth. They also explore other niches like gaming to diversify their offerings.

The Bitmedia engine is a self-serve platform where advertisers can easily set up ad campaigns based on their preferences such as target audience or ad format. The system tracks various metrics for performance evaluation. Account managers help guide advertisers who may be unfamiliar with digital advertising processes.

In terms of building brand loyalty in the crypto space, Bitmedia collaborates closely with brands to craft unique campaigns that resonate with their target audience.

Tanja explains that her company works with various established companies to help them with advertising, specifically branding campaigns. They utilize performance tracking and aim for brand recognition. They also engage in PRS and KOL marketing, creating stories and publishing them on top crypto media outlets while promoting businesses to key opinion leaders. Tanja discusses their previous efforts to use blockchain for advertising but mentions that they are currently focusing on building their own DSP (Demand-Side Platform) for buying traffic and ads from different media outlets. She also mentions plans for a decentralized ad exchange using smart contracts to combat ad fraud. 

In terms of the future of crypto advertising, Tanja believes that traditional advertising technologies should be prioritized over blockchain-based solutions at this point because the technology is not yet mature enough in the crypto market. However, she envisions AI playing a role in future developments within the industry.

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Andy records a video podcast to check in on the current narratives and data points impacting the crypto markets.

With approximately 150 days until the 4th Bitcoin Halving, and less than two months until the likely approval of multiple Bitcoin Spot ETFs, the markets are leaning bullish. 

Bitcoin has been on an upward trend for the last 4 weeks, gaining over 36% in that time. Solana has outperformed Bitcoin and most other assets, gaining 190% in the last four weeks alone.

Andy looks at all this, and much more in today’s market sentiment report.

Watch this episode on YouTube

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Aditya Das is Head of Research at Volcan Capital, a financial services company focused on investment opportunities in El Salvador. 

Aditya has authored a comprehensive research report titled "Invest in El Salvador," which covers various sectors of the country's economy and highlights its emerging opportunities for investors. Volcan Capital has created two investment funds, that are tokenized on the Bitcoin Blockchain. The funds are, the El Salvador Real Estate Investment Trust Fund and the El Salvador Technology Venture Fund.

El Salvador has made significant progress in the last decade, particularly in addressing its issues with gang violence and improving safety. The government-implemented measures have been controversial but effective in reducing crime rates. El Salvador has successfully managed its fiscal deficit and restructured its debt, leading to improved credit ratings and increased foreign investment. President Nayib Bukele is seen as a populist leader who has embraced progressive financial policies and actively communicates with the public through social media platforms like Twitter. 

El Salvador became the first country to make Bitcoin legal tender in 2021. This decision was driven by the need for an alternative currency since El Salvador uses US dollars as its primary currency but lacks monetary sovereignty. Bitcoin offers benefits for remittances and acts as a hedge against potential devaluation or economic instability caused by external factors.

El Salvador has set up legislation and a regulatory framework for Bitcoin service providers, which has attracted prominent exchanges like Bitfinex and Binance. The country offers a separate company registry and clear language in its regulations to support Bitcoin-related companies. El Salvador's embrace of Bitcoin as legal tender also provides a ready-made base of users for these companies. Additionally, the country has created a separate framework for digital asset service providers, embracing digital assets other than Bitcoin. El Salvador's use of geothermal energy from volcanoes for Bitcoin mining adds to its appeal as an innovative hub.

Volcan Capital is ready to assist international capital looking for a geopolitical hedge or growth prospects in this emerging market: in other words, the Singapore or Dubai of 40 years ago.

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Jae Yang is the CEO of Tacen and the Chief Architect of Project TXA. Tacen and Project TXA are sister projects - Project TXA develops the hybrid decentralized exchange protocol (hDEX) and the decentralized settlement layer (DSL), while Tacen develops the world’s first hDEX interfaces for traders to use (Tacen Swap and Tacen Exchange).

Jae Yang is the CEO of Tacen and the chief architect of Project TXA, an open-source project that aims to build a cross-chain settlement network. Tacen is a commercial entity building an exchange on top of the TXA settlement network. 

Both projects were inspired by Jae's frustrations with traditional crypto exchanges including custody issues, lack of transparency in proof of reserves, and centralization. Project TXA seeks to address these issues by providing fast cross-chain transactions and noncustodial exchanges. 

The target audience is experienced traders looking for secure and low-cost options beyond centralized exchanges. Jae Yang also emphasizes compliance with regulations while maintaining user privacy. Tacen Exchange is live on multiple networks with various crypto pairs available for trading. Interested individuals can learn more through technical documentation, code repositories, joining Discord, or visiting the exchange website.

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Collin Woodward is the President and General Counsel of StealthTest. This secure, cloud-based environment enables teams to create their own Ethereum and EVM-compatible test networks for private and secure Web3 development.

StealthTest is designed to ensure industry Web3 projects can protect their privacy, compliance, and IP. With a track record including Chainlink, CertiK, and Gary Vee, StealthTest pioneers scalability, reliability, and swift deployment of secure blockchain apps.

StealthTest is a comprehensive infrastructure solution for smart contract development, testing, and deployments. Nestled securely within cloud-based, private testing environments, the platform provides blockchain infrastructure to service every phase of the Web3 product lifecycle.

This allows developers to direct their energies toward crafting innovative applications, liberating them from the complexities of node deployments and environmental variables.

Engineered for optimal functionality, StealthTest is designed to minimize maintenance and maximize cost efficiency via resource autoscaling and frictionless network upgrades. This is accomplished through a proven, repeatable node deployment strategy and a hands-off management approach, eliminating the common headaches associated with self-managed node upkeep. StealthTest supports all EVM networks.

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Jonathan Bertrand is CEO at D-Central Technologies, a Bitcoin mining company empowering pleb miners to industry giants. D-Central is North America and Europe's one-stop shop for hardware, hosting, and repair.

Since its inception in 2016, D-Central has been at the forefront of innovation and development within the Bitcoin mining sector. The company operates a physical and online retail store making it easy for hobbyists to access Bitcoin mining hardware. D-Central also operates a comprehensive Bitcoin ASIC Service Center, which includes diagnosis and repair of ASIC hardware issues, firmware updates, overclocking, optimization of hardware performance, cleaning and maintenance for prolonged life expectancy, replacement parts for damaged or worn parts, technical support and troubleshooting assistance.

D-Central runs a comprehensive Bitcoin Mining Hosting solution, and now sell Bitcoin Space Heaters. These heaters repurpose the heat generated from cryptocurrency mining, turning what was once considered waste into a valuable resource for homeowners. As Bitcoin miners work tirelessly to validate transactions and secure the blockchain, they produce a significant amount of heat. Instead of letting this heat dissipate into the surroundings, Bitcoin Space Heaters capture and channel it to warm living spaces, ensuring that every joule of energy is put to good use.

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Riad Wahby is the CEO and co-founder at Cubist, a company focused on key management solutions for Web3. Riad has a background in electrical engineering and computer science, particularly zero-knowledge proofs. Cubist was founded after Riad and the team identified the problem of key security as a major challenge in Web3 applications.

Cubist began as a developer of hardware-backed, non-custodial key storage and signing infrastructure that enables institutional blockchain staking providers to protect staking keys and secure withdrawals. 

The company was started by Wahby, his co-founder, former fintech COO and fraud prevention expert Ann Stefan, and two other Computer Science and Engineering professors from Carnegie Mellon and UC San Diego.

Cubist has just launched a first-of-its-kind Wallet-as-a-Service platform called CubeSigner to support everything from loyalty programs to market makers to games to custody platforms across virtually every chain.

The WaaS solution is differentiated in that applications can request signatures through revocable signing sessions via simple API calls, and then the WaaS signs from within secure hardware. As a result, keys are constantly safe because users can’t accidentally leak keys and attackers can’t steal keys.

CubeSigner is designed to solve the trade-off between convenience/usability and security when it comes to managing keys.

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Ayush Ranjan is the Co-Founder and CEO at Huddle01, whose mission is to democratize WebRTC and make it more private, secure, and scalable.

Huddle01 is building a decentralized real-time communication network. Developers can leverage their suite of developer-friendly SDKs to enable powerful audio/video experiences on your app with just a quick plug in.

Ayush talks about privacy concerns with video communication platforms like Zoom and how that led him to create Huddle01, a peer-to-peer video calling platform with added layers of security and scalability. Ayush explains how WebRTC works and its evolution from peer-to-peer to server-based communication. He highlights the challenges of centralization, such as lack of content encryption and latency issues caused by distant servers.

Ayush discusses the concept of a people-powered communication network, where individuals can become nodes and power calls without relying on centralized servers. This leads to increased privacy, reduced latency, and the creation of a new bottom-up economy. Ayush also highlights features of Huddle01 that differentiate it from platforms like Zoom, such as seamless integration with popular streaming sites, enhanced privacy options, crypto primitives for avatars, and cheaper call recordings using filecoin storage. Andy acknowledges the importance of building user-friendly platforms regardless of users' familiarity with web3 technology. The conversation then shifts to the concept of "DePIN," which refers to leveraging blockchain technology for decentralized physical infrastructures. Examples include Helium's approach to creating a decentralized 5G mobile network and Filecoin's role in enabling individuals to become storage providers. The discussion concludes by emphasizing the need for more affordable communication infrastructure in order to reduce costs currently associated with centralized systems.

Ayush describes the different layers of Huddle01, including the app layer for consumers, the SDK layer for developers, and the protocol layer for miners and validators. Ayush envisions a future where Huddle powers all communication platforms, making calls more immersive and solving global problems more effectively. Looking ahead, Ayush sees a utopian future where humans explore outer space and achieve higher levels of energy consumption through advanced infrastructure systems like Dyson Spheres.

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