Dr. Cary Presant joins Drew for a discussion about the current state of medical care in America. They explore assessing your doctor ahead of time and how to identify the right kind of doctor for your specific needs and how to go about changing doctors. They also explore the merits of having your own copy of your medical information and taking it with you when traveling or seeking a second opinion.

Dr. Daniel Amen joins Dr. Drew for an examination of the current state of mental health and psychoanalysis. They also explore the progression of brain scan therapy and what new technologies Dr. Amen is using in his practice. Later, Dr. Amen's wife Tana joins the show to discuss some of her past medical experiences and how that led her to write her current book.

Attorney Mark Eiglarsh joins Dr. Drew for a long form discussion about the Jodi Arias trial. They examine the way that the media has been covering the trial and their own personal thoughts as well as taking questions from listeners.

David Sheff joins Dr. Drew for a conversation about addiction and how the disease should be understood and treated. David shares his personal experiences with his son and what he learned throughout the process. They also take listener calls about what constitutes an unfit parent and managing binge usage of prescription medication.

Dr. Suzanne Gilberg-Lenz returns to talk with Drew about being a doctor in media, the pros and cons of getting the HPV vaccine and they take a listener call about raising female libido.

Donna Rice Hughes joins Dr. Drew for a discussion about the desensitization of Americans in regards to easily accessible pornographic content. Drew then takes calls on bulimia, Suboxone and the alcoholic gene.

Doug Benson joins Dr. Drew for a conversation about Doug's comedy, their thoughts on marijuana and how being known as a 'pot comic' has impacted Doug's career. They also a listener call about the difference between casual drinking and alcoholism.

Former Dr. Drew Podcast guests Bob Forrest and Chris 'Boomer' Boehm return to tell the hilarious and uplifting story of their long friendship and road to recovery.

Mike Catherwood and training expert Lyle McDonald join Drew for an conversation about all aspects of lifting, training, dieting and physical fitness.

Simone Bienne returns for her fourth appearance on the podcast for an in-depth conversation about codependency and a celebration of the penis in honor of National Masturbation Month. They also get an update from a caller they had previously helped and try to assist a recovering addict in making a decision about a new relationship.