This VJHemOnc podcast explores the evolving role of BTK inhibitors in chronic lymphocytic leukemia (CLL). Constantine Tam, MBBS (Hons), MD, FRACP, FRCPA, Alfred Hospital and Monash University, Melbourne, Australia, discusses long-term SEQUOIA trial (NCT03336333) findings of zanubrutinib in treatment-naïve CLL and extended follow-up from the ALPINE study (NCT03734016) comparing zanubrutinib with ibrutinib in relapsed or refractory disease.

Kerry Rogers, MD, The Ohio State University, Columbus, OH, reviews continuous BTK inhibitor therapy and resistance mechanisms, while Romain Guièze, MD, PhD, CHU Clermont Ferrand, Clermont Ferrand, France, discusses the STAIR trial (NCT04963946) evaluating acalabrutinib discontinuation in older, frail patients. Jennifer Woyach, MD, The Ohio State University, Columbus, OH, highlights a Phase I trial (NCT04775745) trial investigating rocbrutinib and Phase III BRUIN-CLL314 trial (NCT05254743) results comparing pirtobrutinib with ibrutinib.