In this episode of The Feldman Protocol, how does insulin influence cancer cell behavior — and what does that mean for metabolic approaches to the disease? Dave sits down with Isabella Cooper (PhD) to explore the glucose-ketone index and its practical limits, the role of glutamine alongside glucose in cancer metabolism, how mitochondrial dysfunction and cardiolipin loss may relate to tumor progression, the case for high-dose intravenous vitamin C, osteocyte biology and the surprising systemic roles of osteocalcin, and what makes a rigorous research culture.

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🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

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Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & intro

1:08 – Cancer metabolism overview

2:24 – Glucose-ketone index explained

5:01 – Lean mass hypersponders & glucose

9:18 – Acetone measurement & respiration

13:49 – Insulin, ketones & cancer signaling

19:05 – Growth factors & VEGF discussion

25:29 – Stomach acidity & nutrient absorption

32:08 – How cancer cells originate

35:43 – Cardiolipin, melatonin & apoptosis

43:05 – Diet quality & food as function

52:14 – Chemotherapy & metabolic protocols

1:03:36 – Patient outcomes & biopsy risks

1:14:32 – IV vitamin C trial findings

1:22:07 – Ideal cancer metabolism trial design

1:29:36 – Sunlight, melanin & mitochondria

1:37:20 – Osteocyte biology & osteocalcin

1:46:43 – Research culture & scientific rigor

1:54:36 – Most underappreciated biomarker

#FeldmanProtocol #DaveFeldman #IsabellaCooper #CancerMetabolism #KetogenicDiet #Mitochondria #Insulin #GlucoseKetoneIndex #Osteocalcin #IntravenousVitaminC #Ketosis #MetabolicHealth #LowCarbScience #CancerResearch #Cardiolipin #Osteocytes #BloodWork #Hyperinsulinemia #MitochondrialHealth #PodcastScience

In this episode of The Feldman Protocol, what does beta-hydroxybutyrate between meals actually reveal about a person's insulin state — and why might that matter for understanding chronic disease risk? Dave sits down with Isabella Cooper (PhD), a biochemistry and pathophysiology scientist whose research spans assay quality control, hyperinsulinemia detection, ketone thresholds, mitochondrial function, and the lipid energy model, making the case that personalized insulin thresholds — not population-wide cutoffs — may be key to identifying subclinical metabolic dysfunction.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/48` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & intro1:06 – Isabella's background & credentials3:05 – East-meets-West medicine upbringing5:43 – Ballet, modeling & low-carb insights6:36 – Industrial design degree & lab thinking8:58 – Assay quality problems in undergrad lab12:08 – Coefficient of variation explained17:01 – Standardizing vortex & sample handling27:30 – Back to timeline: the 15-year gap39:52 – Pregnancy, diapers & toxicology deep dive53:06 – Old physiology papers vs modern science1:00:05 – Osteocalcin hypothesis & being wrong1:06:48 – Ben Bikman, mitochondria & insulin1:19:40 – Headwinds for low-carb research1:34:19 – Personalized insulin threshold concept1:41:28 – Beta-hydroxybutyrate as insulin surrogate1:51:44 – Leptin, IGF-1 & multi-marker detection2:09:09 – Subclinical hyperinsulinemia marker cluster2:14:20 – Fasting, lipid dynamics & VLDL traffic#FeldmanProtocol #DaveFeldman #IsabellaCooper #Hyperinsulinemia #Ketosis #Mitochondria #MetabolicHealth #InsulinResistance #BetaHydroxybutyrate #LowCarb #ChronicDisease #LipidEnergyModel #AssayQuality #KetoneThreshold #LaboratoryScience #Bioenergetics #BloodTesting #Inflammation

In this episode of The Feldman Protocol, how much does metabolic health shape cardiovascular risk beyond what standard lipid markers can reveal? Dave Feldman sits down with Scott Murray (MD), a UK-based interventional cardiologist, to explore plaque imaging and its limitations, the role of visceral and perivascular fat in heart disease, the lipid energy model and lean mass hyper-responders, cardiac fuel metabolism and heart failure with preserved ejection fraction, and the challenges of conducting and interpreting cardiovascular trials.

🔥 This episode is sponsored by us --

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(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

X/Twitter: `https://x.com/realDaveFeldman`

Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & Scott's intro

14:21 – Scott's cardiology practice

17:28 – Invasive vs. CT angiography

24:49 – Collaterals & microvascular function

34:31 – Glycocalyx & endothelial health

40:28 – Perivascular fat & imaging

51:14 – Imaging, CAC, and plaque noise

1:00:04 – Lipid hypothesis & population context

1:07:05 – CT plaque measurement variability

1:19:42 – Perivascular inflammation & Caristo scoring

1:29:07 – Lipid energy model discussion

1:49:43 – LP(a), acute-phase markers & reverse causation

2:05:01 – LMHR study timeline & next scans

2:22:57 – Heart fuel preference & HFpEF

2:39:08 – PCSK9 trials & all-cause mortality

2:52:06 – Run-in periods & trial design concerns

3:05:00 – Context, guidelines & patient conversations

3:17:35 – GLP-1 peptides & obesity biology

3:26:28 – Where to find Scott & closing thoughts

#FeldmanProtocol #DaveFeldman #ScottMurray #PreventiveCardiology #HeartHealth #LipidHypothesis #LeanMassHyperResponder #CTAngiography #PlaqueImaging #CardiovascularResearch #MetabolicHealth #LipidEnergyModel #HeartFailure #LPa #GLP1 #TrialDesign #Cardiology #LowCarb #BloodWork

In this episode of The Feldman Protocol, what actually drives cardiovascular disease in a metabolically healthy, lean individual — and is elevated LDL the most important variable to consider? Darius Sharpe (ER nurse and lean mass hypersponder community member) discusses his unexpected CAC score at age 38, his theory on postprandial glucose and vascular damage, a personal episode of atrial fibrillation, the Keto CTA study's Clearly data controversy, and what ER nurses observe firsthand about metabolic illness.

🔥 This episode is sponsored by us --

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Private blood testing services

🩸Over 300 blood tests

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❤️ We love our customers

(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

X/Twitter: `https://x.com/realDaveFeldman`

Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & CAC score reveal

4:51 – Darius's CAC scan background

9:07 – First-phase insulin response explained

15:47 – CAC result context & vessel findings

22:09 – Darius investigates his own cardiac risk

33:43 – Atrial fibrillation episode & AFIB physiology

43:28 – Electrolytes, magnesium, and sodium discussion

51:04 – Stress tests vs. imaging: a patient case

58:01 – Metabolic syndrome underdiagnosis in hospitals

1:03:09 – Dave's diet experiments & LMHR data

1:09:18 – Fat bomb experiment: NMR findings

1:20:53 – Lipid energy model & structural hypothesis

1:30:37 – Keto CTA: plaque associations & progressors

1:39:41 – Clearly data controversy & scientific transparency

1:51:55 – Glucose, hyperglycemia, and plaque theory

2:05:22 – Raw data release & cards on the table

2:15:01 – ER realities & medication safety

2:29:07 – Lifestyle, habits, and the ER patient perspective

2:39:10 – Where to find Darius & closing thoughts

#FeldmanProtocol #DaveFeldman #DariusSharpe #LeanMassHypersponder #KetoCTA #CACScore #AtrialFibrillation #PostprandialGlucose #MetabolicSyndrome #LipidEnergyModel #CardiovascularHealth #CGM #LDL #InsulinResponse #ERNurse #BloodTesting #HeartHealth #NMRPanel

In this episode of The Feldman Protocol, how well does the prevailing understanding of LDL and cardiovascular disease hold up under close scrutiny? Dave sits down with Malcolm Kendrick (MD) — author, researcher, and longtime cardiovascular disease skeptic — who challenges key assumptions across trial methodology, observational data, Mendelian randomization, clinical trial blinding, nitric oxide's role in vascular health, and the response-to-injury model of atherosclerosis.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/46` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Introduction & cold open1:11 – Malcolm Kendrick's background6:02 – Early contrarian tendencies in medicine16:48 – International cholesterol skeptic network22:13 – Shifting LDL targets over decades39:05 – FH, heterozygous vs. homozygous49:35 – Examining pharmaceutical trial evidence57:00 – Clinical trial blinding & composite endpoints1:07:27 – Data transparency & CTT access questions1:23:11 – Statins, nitric oxide & plausible mechanisms1:37:34 – Mendelian randomization discussed1:54:43 – Audience questions: ApoB & endothelial injury2:05:24 – Kendrick's cardiovascular disease model2:19:44 – Shared models: vascular repair & hemostasis2:38:39 – The Daily Mail lawsuit: origins2:47:32 – Five-year legal battle & court proceedings3:00:01 – CTT emails & trial methodology concerns3:17:29 – LMHR study update & CLEARLY retraction3:33:23 – Where to find Malcolm Kendrick#FeldmanProtocol #DaveFeldman #MalcolmKendrick #CardiovascularDisease #LDLCholesterol #LipidHypothesis #ClinicalTrials #NitricOxide #Atherosclerosis #StatinResearch #HeartHealth #LeanMassHyperresponder #CholesterolDebate #ApoB #MetabolicHealth #EvidenceBasedMedicine #TrialMethodology #Cholesterol

In this episode of The Feldman Protocol, what does it take to recognize and address a compulsive relationship with food — and why does that recognition matter so much? Jen Unwin (clinical and health psychologist) joins Dave to explore the psychology of hope in medical settings, her personal history with carbohydrate-driven food behaviors, the evidence behind ultra-processed food addiction as a proposed clinical category, the WHO/ICD recognition process, GLP-1 medications as one potential tool, and why social context and proximity to trigger foods shape outcomes for so many people.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/45` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Introduction & cold open1:13 – Jen's background in psychology5:44 – Path to clinical training in Manchester12:47 – Hope as a clinical concept21:28 – Positive psychology & the nun study27:02 – Hope's influence on David Unwin's practice35:23 – Jen's personal food history43:02 – Discovering low-carb & the turning point52:22 – Food addiction: Dave's french fry story1:02:47 – Seeking official recognition of food addiction1:09:01 – Building expert consensus on terminology1:15:55 – Treatment outcomes & published research1:27:47 – Comparing food addiction to tobacco history1:36:05 – Proximity, social pressure & behavior change1:47:08 – Behavioral vs. substance-based framing1:54:52 – Prevalence data & retired athlete findings2:02:23 – Audience questions & GLP-1 medications2:33:39 – Nutrient density, protein, and food as fuel2:39:41 – Where to find Jen & closing remarks#FeldmanProtocol #DaveFeldman #JenUnwin #FoodAddiction #UltraProcessedFood #HopeInMedicine #PositivePsychology #LowCarb #BehaviorChange #DSM #FoodAddictionRecognition #CarbohydrateAddiction #GLP1 #NutrientDensity #MentalHealth #SolutionFocused #MetabolicHealth #Keto

In this episode of The Feldman Protocol, how does one family doctor's decades-long frustration with a "progressive, incurable" disease lead to a fundamentally different approach to patient care? Dave Feldman and David Unwin (MD) explore the pivotal 2012 patient encounter that reshaped Unwin's practice, the psychology of behavior change and food addiction, real-world data from a 10,000-patient NHS cohort, collaborative medicine versus authoritarian care, GLP-1 drugs as a last resort, and AI's emerging role in clinical decision-making.

🔥 This episode is sponsored by us --

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🩸Over 300 blood tests

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(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

X/Twitter: `https://x.com/realDaveFeldman`

Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Introduction & cold open

1:24 – David Unwin's background

13:07 – Generational health trends observed

20:19 – Conventional medicine & early career

39:14 – The art vs. science of medicine

52:28 – The ACCORD study discussed

1:04:45 – The 2012 pivotal patient encounter

1:17:13 – Publishing the first 18-patient audit

1:30:06 – Unexpected behavioral changes on diet

1:45:09 – Collaborative medicine & patient partnership

2:02:32 – Evolutionary context for modern diet

2:13:06 – Food addiction & maintenance challenges

2:35:12 – GLP-1 drugs: a nuanced discussion

2:47:23 – Questions from the desk

3:09:27 – Unwin's real-world remission data

3:16:03 – AI in medicine & society

3:44:36 – Technology, freedom & human adaptability

3:59:46 – Closing & where to find David Unwin

#FeldmanProtocol #DaveFeldman #DavidUnwin #LowCarb #MetabolicHealth #Type2Diabetes #DiabetesRemission #BehaviorChange #FoodAddiction #CollaborativeMedicine #NHSData #GLP1 #NutritionalScience #InsulinResistance #RealWorldData #PublicHealthCollaboration #LowCarbGP #AIInMedicine #FamilyMedicine

Part 1 of 2In this episode of The Feldman Protocol, what can a quarter-century of emergency medicine experience reveal about the everyday habits quietly shaping metabolic health outcomes? Darius Sharpe (ER nurse and former paramedic with 24 years in emergency medicine) makes the case that postprandial glucose excursions deserve far more clinical attention, discusses his personal glucose experiments after a low-carb reintroduction of fast food, shares observations on hospital nutrition practices, and weighs in on the calories-in/calories-out vs. carbohydrate-insulin debate.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/42` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & introduction1:10 – Darius introduces himself3:42 – Path from EMT to ER nurse12:09 – Recognizing atypical heart attack symptoms16:07 – Time is tissue: stroke & MI urgency24:33 – Patterns Dave saw responding to 911 calls40:25 – Darius's personal health & family history54:44 – Early lipid labs and what they showed1:01:11 – Nursing school glucose discovery1:13:32 – The In-N-Out glucose experiment series1:21:42 – Joining the LMHR community1:31:40 – Metabolic illness observations during 2020–20221:45:43 – First CGM and self-experimentation1:51:14 – Keto week vs. high-carb week: OGTT comparison1:59:39 – Defining low-carb, keto, and net vs. total carbs2:19:36 – Calories vs. insulin: what both sides get right2:30:58 – Hospital food, juice, and postprandial glucose2:44:29 – Bedside patient education and CGM advocacy#FeldmanProtocol #DaveFeldman #DariusSharpe #MetabolicHealth #BloodSugar #PostprandialGlucose #LeanMassHyperResponder #LMHR #LowCarb #KetogenicDiet #CGM #ContinuousGlucoseMonitor #EmergencyMedicine #ERNurse #InsulinResistance #Cholesterol #HeartHealth #StrokeAwareness #HospitalNutrition

In this episode of The Feldman Protocol, can a practicing family physician's personal health crisis reshape the dietary advice he gives to thousands of patients? Ken Berry (MD) makes the case for low-carbohydrate approaches in managing metabolic conditions, shares his path from rural Tennessee to family medicine, discusses founding the American Diabetes Society as an alternative institution, explores the debate around long-term ketosis and fasting insulin, and joins Dave and audience members in examining how to rebuild trust in medical and scientific institutions.

🔥 This episode is sponsored by us --

Own Your Labs 👉 `https://ownyourlabs.com/sp/40`

Private blood testing services

🩸Over 300 blood tests

💰Extremely affordable

❤️ We love our customers

(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

X/Twitter: `https://x.com/realDaveFeldman`

Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & introduction

1:51 – Ken Berry's background in medicine

8:08 – Path from rural Tennessee to med school

16:03 – Ken's health during his early career

23:01 – Shifting away from standard dietary guidelines

33:42 – Patient signals and expanding the practice

42:17 – Starting a YouTube channel

54:21 – "Lies My Doctor Told Me" and colleague pushback

1:00:18 – Founding the American Diabetes Society

1:05:00 – Audience Q&A begins

1:08:53 – Discussion of long-term ketosis markers

1:18:31 – Talking to loved ones about diet

1:29:14 – Nutrition education in medical schools

1:39:47 – Restoring trust in medical institutions

1:47:00 – Semmelweis, paradigm shifts & patience

1:55:40 – Long-term ketosis safety & ketone measurement

2:09:10 – Blood work as a snapshot: context matters

2:30:28 – Dietary flexibility, travel, and glucose spikes

2:51:05 – Closing remarks & where to find Ken Berry

#FeldmanProtocol #DaveFeldman #KenBerry #LowCarbDiet #KetogenicDiet #CarnivoreDiet #MetabolicHealth #BloodSugar #InsulinResistance #DiabetesManagement #FamilyMedicine #NutritionScience #ProperHumanDiet #CGM #CholesterolCode

In this episode of The Feldman Protocol, can elite athletes truly thrive on fat alone — with zero carbs? Dave sits down with Casey Ruff (personal trainer, nutrition coach, and host of Boundless Body Radio) to explore his journey from gym kid to keto rebel, high-intensity training principles, a rogue low-carb experiment inside a corporate fitness company that produced 732 lbs of fat loss, the LMHR study saga, carnivore adaptation and anxiety relief, and a surprising email from the American Heart Association.

🔥 This episode is sponsored by us --

Own Your Labs 👉 `https://ownyourlabs.com/sp/39`

Private blood testing services

🩸Over 300 blood tests

💰Extremely affordable

❤️ We love our customers

(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

X/Twitter: `https://x.com/realDaveFeldman`

Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

3:17 – Casey's ice hockey obsession

8:05 – A punch that changed everything

12:38 – Two years in Brazil as a missionary

17:03 – From architecture dreams to personal training

21:06 – Finding his calling at the gym

28:51 – High intensity training explained

36:57 – Why sport-specific training is a myth

39:02 – Metabolic carts & the RER deep dive

43:01 – The Biggest Loser metabolic damage case

46:24 – Calories in/out: why it failed everyone

50:25 – Nina Teicholz & The Big Fat Surprise

54:07 – Bonking, glycogen, and fat adaptation

58:10 – Butter-fed athletes & the keto revelation

1:04:13 – Casey's fasted hockey game story

1:06:07 – Going rogue with Diet Doctor meal plans

1:14:02 – Getting the nutrition certification

1:17:17 – The contest winner who changed everything

1:20:19 – 732 lbs lost, 98.1% from fat

1:27:33 – Did results hold after the contest?

1:33:27 – Starting Boundless Body podcast in 2020

1:41:25 – On being a natural podcast host

1:52:17 – The pandemic pivot to virtual training

1:59:08 – Carnivore and the vanishing anxiety

2:04:31 – The LMHR Match Analysis saga begins

2:16:26 – Low Carb Denver 2023 collective gasp

2:23:22 – Dave reveals new Heartflow re-analysis

2:29:35 – The movie & Robin's bipolar decision

2:31:37 – The AHA misinformation email

2:42:14 – Prepping for Arthur Agatston

2:48:42 – Fat adaptation and hockey performance

2:55:39 – Travel strategies: fasting vs. carnivore snacks

2:59:08 – Changing his mind: strict carnivore or not?

3:05:36 – Where to find Casey

#FeldmanProtocol #DaveFeldman #CaseyRuff #LowCarbLife #KetoDiet #CarnivoreDiet #FatAdaptation #HighIntensityTraining #LMHRStudy #CholesterolCode #MetabolicHealth #SeedOils #HeartHealth #NutritionCoach #EnduranceSport #BloodWork #Ketosis #BoundlessBodyRadio