In this week’s episode, we pause from our discussion about DLBCL to talk about the fundamentals of CAR-T, BiTE and autologous transplants, which will lay the foundation for subsequent discussions about DLBCL. These therapies are the talk of the town and have changed/will continue to change our approach to hematologic malignancies - definitely an episode you don’t want to miss.

Content:

- What is CAR-T?

- How are CAR-T cells manufactured?

- What are commercially available CAR-T cell products?

- What are side effects of CAR-T?

- What is BiTE therapy?

- What is the role of autologous transplants in lymphoma?

** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes

Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!

Twitter: @TheFellowOnCall

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This week, we continue our conversation about DLBCL, this time focusing our attention on the management of early stage disease.

In this week’s episode, we delve into the management of advanced stage DLBCL.

If you have not done so, we highly recommend you listen to our hemepath series before proceeding with this episode. Furthermore, if you have not listened to the introduction to DLBCL episode (https://www.thefellowoncall.com/tfocpodcast/dlbclintro) or our early stage DLBCL episode (https://www.thefellowoncall.com/tfocpodcast/dlbclearlystage), we highly recommend doing so, as we will be building on these basics this week.

Content:

- Reminders about diagnosis and staging

- Treatment approaches to advanced staged diffuse large b-cell lyphoma

- Management of double hit/high grade B-cell lymphomas

- Links to important trials

**This episode is sponsored by HemOnc.org

** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes

Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!

Twitter: @TheFellowOnCall

Instagram: @TheFellowOnCall

Listen in on: Apple Podcast, Spotify, and Google Podcast

This week, we continue our conversation about DLBCL, this time focusing our attention on the management of early stage disease.

If you have not done so, we highly recommend you listen to our hemepath series (https://www.thefellowoncall.com/rotationguide-intro-to-hematopathology) before proceeding with this episode. Furthermore, if you have not listened to the introduction to DLBCL episode (Episode 072; https://www.thefellowoncall.com/tfocpodcast/dlbclintro), we highly recommend doing so, as we will be building on these basics this week.

Content:

- What is the role of PET/CT in diagnosis of DLBCL?

- What is the Deauville score?

- How do we approach treatment to early stage DLBCL?

- What are options without radiation?

- What are treatment options for older patients with early stage DLBCL?

**This episode is sponsored by HemOnc.org

** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes

Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!

Twitter: @TheFellowOnCall

Instagram: @TheFellowOnCall

Listen in on: Apple Podcast, Spotify, and Google Podcast

This week, we kick off a new series focusing on diffuse large B-cell lymphoma. In this first episode, we discuss the basics that everyone needs to understand before diving into the management of this disease.

We highly recommend listening to our hemepath series before proceeding with this DLBCL series: https://www.thefellowoncall.com/rotationguide-intro-to-hematopathology

Content:

- Approach to workup for a patient with suspected lymphoma

- FNA vs. Core vs. Excisional biopsy for diagnosis

- Use of PET/CT for staging

- How to risk-stratify patients

- "Double hit" vs. "double expressor"

**This episode is sponsored by HemOnc.org

** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes

Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!

Twitter: @TheFellowOnCall

Instagram: @TheFellowOnCall

Listen in on: Apple Podcast, Spotify, and Google Podcast

We revisit a topic covered previously as part of our “Heme/Onc Emergencies” series: heparin-induced thrombocytopenia (HIT) in Episode 017. As part of our return, we dive deeper into the pathophysiology, principles of diagnosis, and management of HIT to help you to better understand how to approach the question of “is this HIT?” as a Hematology consultant and, more importantly, how to guide management based on your index of suspicion.

Content:

- What is the pathogenesis of HIT?

- What are risk factors for HIT?

- How do we diagnose HIT?

- What are the assays that we use to make this diagnosis and how do the assays work?

- Practical points about management of HIT/HITT

** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes

Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!

Twitter: @TheFellowOnCall

Instagram: @TheFellowOnCall

Listen in on: Apple Podcast, Spotify, and Google Podcast

This week in our hematological consultation series, we continue our discussion on von Willebrand disease (vWD), this time focusing on the type 2 subtypes and we also discuss management.

In case you missed it, we recommend checking out episode 069 for Part I of this vWD series, covering taking a bleeding history and about Type 1 and Type 3 disease.

Content:

- What testing do we send for suspected vWD (refresher)

- What to do if type 2 vWD is suspected?

- What are the different subtypes of Type 2 vWD?

- What is "platelet-type vWD"?

- What is the approach to perioperative management?

** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes

Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!

Twitter: @TheFellowOnCall

Instagram: @TheFellowOnCall

Listen in on: Apple Podcast, Spotify, and Google Podcast

We resume our hematological consultation series with an overview of von Willebrand disease, the most common inherited bleeding disorder. In this episode, we talk about the initial steps we should take to evaluate suspected von Willebrand disease (vWD) and how to differentiate the various subtypes. We will focus on vWD type 1 and 3! Be sure to tune in next week as we discuss vWD type 2 and management.

Content:

- Taking a bleeding history

- What is von Willebrand factor?

- What tests should we order for diagnosis?

- What are the different types of vWD?

- What is the DDAVP challenge?

** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes

Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!

Twitter: @TheFellowOnCall

Instagram: @TheFellowOnCall

Listen in on: Apple Podcast, Spotify, and Google Podcast

This week, we complete our breast cancer series, focusing on triple-negative breast cancer (TNBC). The last few months have been quite the journey! Please continue to refer to our shownotes to help navigate this complex disease treatment paradigm.

Content:

- What is the data about recurrence of disease of TNBC?

- The history of how we got to our current standards of care

- Important trials to support our current treatment paradigm

** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes

Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!

Twitter: @TheFellowOnCall

Instagram: @TheFellowOnCall

Listen in on: Apple Podcast, Spotify, and Google Podcast

We are not yet done with our breast cancer series, but we could not wait to share this incredibly personal conversation with a patient with a recent breast cancer diagnosis. This week, we sit down with Kaele Leonard, who herself is a Pulmonary/Critical Care fellow at Vanderbilt University Medical Center who was diagnosed with breast cancer in her early 30s.

As physicians, we don’t always get to hear what the journey through diagnosis, treatment, and follow up looks like from a patient’s perspective. We are so grateful to Dr. Leonard for opening up about this with us.

Content:

- The patient experience of finding out results and subsequent management

- Importance of discussing fertility preservation

- Financing fertility preservation

- Role of “cold caps” for our patients (https://www.breastcancer.org/treatment-side-effects/hair-loss/cold-caps-scalp-cooling)

- The “post-cancer crash”

** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes

Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!

Twitter: @TheFellowOnCall

Instagram: @TheFellowOnCall

Listen in on: Apple Podcast, Spotify, and Google Podcast

This week, we continue our discussion about metastatic breast cancer, focusing on HER2+ disease.

Content:

- What is the data about recurrence of disease of different breast cancer subtypes?

- The history of how we got to our current standards of care

- Important trials to support our current treatment paradigm

** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes

Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!

Twitter: @TheFellowOnCall

Instagram: @TheFellowOnCall

Listen in on: Apple Podcast, Spotify, and Google Podcast