The Gary Null Show

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Researchers investigate cancer-fighing properties of mango

Texas A&M University

In addition to being one of the most important tropical fruits consumed worldwide, recent studies by researchers at the Institute for Obesity Research and Program Evaluation at Texas A&M University in College Station have shown that mangoes also may help prevent breast cancer. Talcott and others recently completed one in vitro study and one using mice to see if the polyphenols found in mango did, in fact, exhibit inflammation- and cancer-fighting properties. “There was already some research done showing that polyphenolic compounds, such as those found in the mango, have cancer-fighting properties,” Talcott said. “Those compounds appear to have antioxidant properties that may contribute to decrease oxidative stress, which can lead to the onset of chronic diseases such as cancer. In addition to that, polyphenolics have been shown to be anti-inflammatory.” Talcott said interest in mango has been increasing in recent years and experimental data has already shown bioactive compounds present in mangoes exert anti-inflammatory, anti-carcinogenic, antiviral and antibacterial properties.  “Based on this premise, we extracted mango polyphenols and tested their effects in vitro, or separate from their normal biological context, on commercially obtained non-cancer and cancer breast cells,” she said. These results of the study indicate that the cell-killing effects of mango polyphenols are specific to cancer cells, where inflammation was reduced in both cancer and non-cancer cells, seemingly through the involvement of miRNA-21 – short microRNA molecules associated with cancer,” Talcott said. A second study by this research group using hairless mice showed mango polyphenols also suppressed cell proliferation in the breast cancer BT474 cell line and tumor growth in mice with human breast carcinoma cells transplanted into them.

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Ginseng can treat and prevent influenza and RSV, researcher finds

Georgia State University

Ginseng can help treat and prevent influenza and respiratory syncytial virus (RSV), a respiratory virus that infects the lungs and breathing passages, according to research findings by a scientist in Georgia State University’s new Institute for Biomedical Sciences. In a recent issue of Nutrients and an upcoming publication of the International Journal of Molecular Medicine, Sang-Moo Kang reports the beneficial effects of ginseng, a well-known herbal medicine, on human health. He partnered with a university and research institutes in South Korea that wanted international collaborative projects to study if ginseng can be used to improve health and protect against disease because of the potential benefit in fighting these viruses. There are no vaccines available for RSV, which affects millions and is the leading cause of inflammatory bronchiolitis pneumonia and viral death in infants and in some elderly adults. In his study published in Nutrients, Kang investigated whether red ginseng extract has preventive effects on influenza A virus infection. He found that red ginseng extract improves the survival of human lung epithelial cells infected with influenza virus. Also, treatment with red ginseng extract reduced the expression of genes that cause inflammation.

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New study illustrates that potato protein ingestion strongly increases muscle protein synthesis rates at rest and during recovery from exercise

Maastricht University, The Netherlands

Exercise enthusiasts have long presumed animal protein to be superior to plant-derived options for muscle protein synthesis due to its essential amino acid profile. While many plant proteins are deficient in one or more essential amino acids necessary for optimal muscle growth and repair, a new randomized controlled study published in Medicine & Science in Sports & Exercise shows that plant-derived proteins can still induce strong anabolic responses. Researchers at Maastricht University, The Netherlands, found that consuming 30 grams of potato-derived protein concentrate following resistance exercise strongly increased muscle protein synthesis rates to levels that did not differ from the response following the ingestion of an equivalent amount of milk protein concentrate. In general, plant-derived proteins are considered to have lesser anabolic properties, due to their lower digestibility and incomplete amino acid profile. The results show that ingestion of 30 g potato-derived protein will support muscle growth and repair at rest and during recovery from exercise.”

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Antipsychotic medication during pregnancy does affect babies

Monash University (Australia) 

A seven-year study of women who take antipsychotic medication while pregnant, proves it can affect babies. The observational study, published in the journal PLOS ONE, reveals that whilst most women gave birth to healthy babies, the use of mood stabilisers or higher doses of antipsychotics during pregnancy increased the need for special care after birth with 43 per cent of babies placed in a Special Care Nursery (SCN) or a Neonatal Intensive Care Unit (NICU), almost three times the national rate in Australia. As well as an increased likelihood of the need for intensive care, the world-first study shows antipsychotic drugs affects babies in other ways; 18 per cent were born prematurely, 37 per cent showed signs of respiratory distress and 15 per cent developed withdrawal symptoms.

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Beetroot-hawthorn berry blend may boost heart health

University of Texas, May 27, 2022

A blend of beetroot and Hawthorn berry may boost the activity of an enzyme linked to improved heart health, suggests a new study from Texas. Researchers from the University of Texas report that the herbal blend could improve the status of nitric oxide in the body – nitric oxide (NO) is a potent vasodilator, or compound that promotes the dilation or relaxation of blood vessels, thereby easing blood pressure and boosting heart health. “The strategy of formulating a combination of natural products and botanicals chosen specifically for their NO activity shows promise in restoring NO [control] in human subjects at risk for cardiovascular disease for use as a dietary supplement,” wrote researchers in Nutrition Research. Dr Bryan explained what makes the combination unique is beet root and hawthorn play a unique and critical role.” Beetroot was chosen because it was found to contain high levels of nitrate, while hawthorn berries have a high activity of the enzyme nitrite reductase, which converts nitrite to nitric oxide.

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Vitamin D needed for male fertility

Copenhagen University Hospital

The journal Human Reproduction reported the finding of Danish researchers of a role for vitamin D in sperm motility:  the movement of spermatozoa that is necessary for fertilization. Martin Blomberg Jensen of Copenhagen University Hospital and his associates evaluated motility in sperm samples from 300 Danish men.  Blood samples were analyzed for 25-hydroxyvitamin D, parathyroid hormone and other factors. Forty-four percent of the subjects were found to have insufficient vitamin D levels, which were inversely correlated with parathyroid hormone.   Increasing vitamin D levels were associated with greater sperm motility as well increased progressive motility, which is the highest grade of sperm motility, applied to sperm that swim rapidly in a straight line. In an in vitro experiment utilizing sperm samples donated by 40 men, vitamin D3 was demonstrated to increase intracellular calcium via vitamin D receptor-mediated calcium release, improve sperm motility, and induce the acrosome reaction, which is needed for fertilization of the ovum. “Our study uncovers some of the functions of vitamin D and generates new hypotheses. This is an intriguing finding, because it suggests that vitamin D has an effect on sperm movement and function.”

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Aromatherapy can reduce post-surgical opioid use by half, preliminary US study finds

University of Pittsburgh

Aromatherapy reduces post-surgical opioid use by half in hip replacement patients anxious before their operation, according to a new preliminary study being presented at the annual meeting of the European Society of Anaesthesiology and Intensive Care (ESAIC) in Milan. Previous research has shown that anxiety, depression and catastrophising (patients who believe they are going to die during surgery) increase post-operative pain and opioid use by up to 50%. Aromatherapy, the use of essential oils to enhance wellbeing, has been used for thousands of years and a number of recent studies have found that lavender and peppermint aromatherapy, in particular, can reduce anxiety.1 Participants are randomised to an active treatment (aromatherapy) or placebo group. Those in the active treatment group are given a lavender and peppermint “aromatab”, an adhesive patch that slowly releases essential oils when stuck onto clothes, skin or a hospital gown, to wear from at least an hour before their operation. The patches are changed every 12 hours and are worn for 72 hours after surgery. Those in the placebo group wear a patch which emits sweet almond oil – an oil not credited with anxiety-lowering qualities. Total opioid use in the first 48 hours after surgery was 50% lower in the aromatherapy group (12 OME) than in the placebo group (24.75 OME).  (OME, oral morphine equivalent, is a measure that allows comparison between different drugs and methods of administration).

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Coffee consumption link to reduced risk of acute kidney injury, study finds

Johns Hopkins University School of Medicine

If you need another reason to start the day drinking a cup of joe, a recent study by Johns Hopkins Medicine researchers has revealed that consuming at least one cup of coffee a day may reduce the risk of acute kidney injury (AKI) when compared to those who do not drink coffee. The findings, published in the journal Kidney International Reports, show that those who drank any quantity of coffee every day had a 15% lower risk of AKI, with the largest reductions observed in the group that drank two to three cups a day (a 22%–23% lower risk).

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Study confirms benefit of supplements for slowing age-related macular degeneration

National Eye Institute, June 2

The Age-Related Eye Disease Studies (AREDS and AREDS2) established that dietary supplements can slow progression of age-related macular degeneration (AMD), the most common cause of blindness in older Americans. In a new report, scientists analyzed 10 years of AREDS2 data. They show that the AREDS2 formula, which substituted antioxidants lutein and zeaxanthin for beta-carotene, not only reduces risk of lung cancer due to beta-carotene, but is also more effective at reducing risk of AMD progression, compared to the original formula. “Because beta-carotene increased the risk of lung cancer for current smokers in two NIH-supported studies, our goal with AREDS2 was to create an equally effective supplement formula that could be used by anyone, whether or not they smoke,” said Emily Chew, M.D., at the National Eye Institute (NEI).” In AREDS2, begun in 2006, Chew and colleagues compared the beta-carotene formulation to one with 10 mg lutein and 2 mg zeaxanthin instead. Like beta-carotene, lutein and zeaxanthin are antioxidants with activity in the retina. The beta-carotene-containing formation was only given to participants who had never smoked or who had quit smoking. At the end of the five-year AREDS2 study period, the researchers concluded that lutein and zeaxanthin did not increase risk for lung cancer, and that the new formation could reduce the risk of AMD progression by about 26%.

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Exercise amplifies immune attack on pancreatic cancer

New York University Langone Health, June 2

Aerobic exercise reprograms the immune system to reduce pancreatic tumor growth and amplify the effects of immunotherapy, a new study finds. Published online in Cancer Cell, the study provides new insight into how the mammalian immune system, designed to attack foreign invaders like bacteria, can also recognize cancer cells as abnormal. Exercise-induced increases in levels of the hormone adrenalin cause changes to the immune system, say the study authors, including in the activity of cells that respond to signaling protein interleukin-15 (IL-15). The current study found that exercise promotes the survival of CD8 T cells sensitive to IL-15, and doubles the number of them homing to pancreatic ductal adenocarcinoma (PDAC) tumors in mice. Such “effector” T cells have been shown by other studies to be capable of killing cancer cells. Other tests found that aerobic exercise for 30 minutes five times a week reduced the rate of cancer formation by 50 percent in one mouse model of PDAC, and reduced tumor weight by 25 percent in another model, in which mice ran on treadmills for three weeks. Our findings show, for the first time, how aerobic exercise affects the immune microenvironment within pancreatic tumors,” says first author Emma Kurz, MD, Ph.D., at NYU Grossman School of Medicine’s Vilcek Institute of Graduate Biomedical Sciences.

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Antibiotics wreak havoc on athletic performance

University of California at Riverside, June 1

New research demonstrates that by killing essential gut bacteria, antibiotics ravage athletes’ motivation and endurance. The UC Riverside-led mouse study suggests the microbiome is a big factor separating athletes from couch potatoes. Other studies have examined the way that exercise affects the microbiome, but this study is one of few to examine the reverse — how gut bacteria also impact voluntary exercise behaviors. Voluntary exercise involves both motivation and athletic ability. Researchers confirmed through fecal samples that after 10 days of antibiotics, gut bacteria were reduced in two groups of mice: some bred for high levels of running, and some that were not. So, when wheel running in the athletic mice was reduced by 21 percent, researchers were certain the microbiome damage was responsible. In addition, the high runner mice did not recover their running behavior even 12 days after the antibiotic treatment stopped.

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Study: Trans Fat Hides in at Least a Quarter of Supermarket Foods

Environmental Working Group, May 22

A new analysis  by Environmental Working Group has found that harmful artificial trans fatty acids lurk in more than 27 percent of more than 84,000 processed foods common in American supermarkets.  Another 10 percent contain ingredients likely to contain trans fat. EWG analysts used information from EWG’s Food Scores database and mobile app  to determine which foods contained partially hydrogenated oils and other trans fat containing-ingredients. The interactive, searchable tool rates more than 84,000 foods and 5,000 ingredients based on nutrition, ingredient and processing concerns. In most cases, the products’ trans fat content on the nutrition label doesn’t add up. The reason: an obscure loophole in federal food labeling regulations that allows food processors to round off less than half a gram of trans fat per serving to zero. A single serving of more than 400 foods in the Food Scores database contained enough trans fat to exceed the World Health Organization’s recommended limit of less than 2 grams per day for an adult who consumed a 2,000 calorie diet, the analysis said.

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Coffee drinking again linked with longer life

Jinan University (China), June 1 2022. 

Yet another study has found an association between coffee drinking and a lower risk of premature mortality. The research was reported n the Annals of Internal Medicine. The investigation included 171,616 men and women who did not have cancer or heart disease upon enrollment between 2006 to 2010 in the UK Biobank prospective cohort study. Participants were 37 to 73 years old at recruitment. During a 7-year median follow-up period, participants who consumed unsweetened coffee had up to a 29% lower risk of death (which was associated with drinking 2.5 to 4.5 cups per day) compared to those who did not drink coffee. Participants who drank sugar-sweetened coffee had up to a 31% lower risk, associated with consuming 1.5 to 2.5 cups per day. The association between artificially sweetened coffee and mortality risk was inconclusive. “This prospective analysis found that moderate consumption of unsweetened coffee and that of sugar-sweetened coffee were associated with similar reductions in risk for all-cause, cancer-related, and cardiovascular disease-related mortality,” authors Dan Liu, MD, of Jinan University and colleagues concluded.

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Vegan diet might ease diabetic nerve pain

Lenox Hill Hospital (NYC), May 28th, 2022 

A vegan diet might help people with diabetes-related nerve damage shed weight and find some pain relief, a small pilot study suggests. In the new study, researchers tested whether a vegan diet could help people with type 2 diabetes and painful nerve damage in their feet or hands. The investigators found that over 20 weeks, the 17 people they assigned to the diet lost an average of 15 pounds. At the same time, blood flow to their feet improved and their pain eased up. The dieters were told to limit themselves to 20 to 30 grams of fat per day, and to load up on “low GI” foods, which are foods that do not cause a large surge in blood sugar. Breakfast might include oatmeal with raisins, Wells said, while dinner could be lentil stew, or a vegetable stir-fry with rice.  After about five months, the vegan group had lost 15 pounds, on average, versus about 1 pound in the comparison group. They also reported bigger improvements on a standard pain-rating survey.

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About 3 grams a day of omega-3 fatty acids may lower blood pressure, more research needed 

Macau University of Science and Technology (China)

About 3 grams daily of omega-3 fatty acids, consumed in foods or supplements, appears to be the optimal daily dose to help lower blood pressure, according to a research review published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association. According to our research, the average adult may have a modest blood pressure reduction from consuming about 3 grams a day of these fatty acids,” said study author Xinzhi Li, M.D., Ph.D., at Macau University of Science and Technology in Macau, China. Researchers analyzed the results of 71 clinical trials from around the world published from 1987 to 2020.  The analysis found: Compared to adults who did not consume EPA and DHA, those who consumed between 2 and 3 grams daily of combined DHA and EPA omega-3 fatty acids (in supplements, food or both) had reduced systolic (top number) and diastolic (bottom number) blood pressure by an average 2 mm Hg. Consuming more than 3 grams of omega-3 fatty acids daily may have added blood pressure-lowering benefit for adults with high blood pressure or high blood lipids: At 3g a day of omega-3s, systolic blood pressure (SBP) decreased an average of 4.5 mm Hg for those with hypertension, and about 2 mm Hg on average for those without. At 5g a day of omega-3s, SBP declined an average of nearly 4 mm Hg for those with hypertension and less than 1 mm Hg on average for those without.

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When is the best time of day to exercise? The answer may be different for men and women

Skidmore College

When should I fit exercise within my daily schedule? For most, the answer depends on our family’s schedule and working hours, and perhaps on whether we’re “larks” or “night owls.” But over the past decade, researchers have found that much more hangs on this question than these constraints. That’s because recent findings suggest that the effectiveness of exercise depends on the time of day (Exercise Time Of Day, ETOD). Now, a randomized controlled trial not only confirms convincingly that ETOD affects the effectiveness of exercise, but also shows that these effects differ between types of exercise, and between women and men. Principal investigator Dr. Paul J Arciero, a professor at the Health and Human Physiological Sciences Department  said: “Here we show for the first time that for women, exercise during the morning reduces belly fat and blood pressure, whereas evening exercise in women increases upper body muscular strength, power, and endurance, and improves overall mood and nutritional satiety.”

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Diabetes may weaken teeth and promote tooth decay

Rutgers University, May 31, 2022

People with both Type 1 and Type 2 diabetes are prone to tooth decay, and a new study from Rutgers may explain why: reduced strength and durability of enamel and dentin, the hard substance under enamel that gives structure to teeth. Researchers induced Type 1 diabetes in 35 mice and used a Vickers microhardness tester to compare their teeth with those of 35 healthy controls over 28 weeks. Although the two groups started with comparable teeth, enamel grew significantly softer in the diabetic mice after 12 weeks, and the gap continued to widen throughout the study. Significant differences in dentin microhardness arose by week 28.

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Could beating drums help beat autism?

King’s College London, June 1, 2022

The percussive skill needed to bang out rhythms on a drum may help improve socializing, inhibition control and focus among teens with autism, new research suggest The finding follows work with 36 teens with an autism spectrum disorder. Half were randomly chosen to receive two months’ worth of drum training, based on a standard electronic drum kit program. The upshot: Learning to drum appeared to reduce hyperactive behavior and improve teens’ ability to focus and pay attention, she said. The activity also seemed to enhance communication “between brain regions responsible for inhibitory control, action-outcome monitoring, and self-regulation.” Drumming requires “motor planning and timing accuracy” as well as focused attention and inhibition control.  Those assigned to drum training were given two 45-minute sessions a week for eight weeks. The other group received no drum training.The findings were published online May 31 in the Proceedings of the National Academy of Sciences.

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Vitamin D may restore the body’s natural barrier against ovarian cancer

Nagoya University (Japan)

Ovarian cancer has one of the highest death rates of all cancers. One reason for this is that the cancer turns the body’s defenses against itself. However, new research from Nagoya University published in Matrix Biology suggests that vitamin D can effectively prevent one of the key pathways used by this cancer. Ovarian cancer often undergoes a process called peritoneal metastasis. In this process, its cells detach from their primary site in the ovary and travel to a secondary implantation site, such as the peritoneal wall or diaphragm. The peritoneum defends against this process using a barrier consisting of mesothelial cells, which prevent the adhesion of cancer cells and limit their spread. However, ovarian cancer gets around this defense by transforming the protective mesothelial cells into cancer-associated mesothelial cells. This creates an environment that helps metastasis, assisting the spread of cancer around the body.

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Herbal supplement shows promise against lung cancer

University of Technology at Sydney

Berberine, a natural compound found in plants such as barberry and goldenseal, suppresses the proliferation of lung cancer cells in the lab, new research shows. It also reduces airway inflammation and damage to healthy lung cells exposed to chemicals from cigarette smoke. The evaluation of berberine’s effect on non-small cell lung cancer has just been published in the journal Pharmaceutics. It shows that berberine exhibits potent anticancer activity, suppressing cancer cell growth in vitro. The study follows research recently published in Antioxidants, also led by Dr. Dua, showing berberine can inhibit oxidative stress, and reduce inflammation and cellular senescence induced by cigarette smoke extract in lab-grown human healthy lung cells.

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N-acetylcysteine could improve concussion recovery

Midwestern University (Arizona)

A study reported on April 8, 2022, in The Journal of Trauma and Acute Care Surgery revealed improvement in symptoms of concussion among older men and women with mild traumatic brain injury (TBI) who received supplements containing the antioxidant amino acid N-acetylcysteine (NAC). Free radicals produced following brain injury react with lipids to create toxic molecules within the first hours following a traumatic brain injury. Dr McPherson and his associates suggested that the damage caused by these molecules could be responsible for the symptoms that occur after a concussion and that the use of compounds such as NAC could help mitigate some of these symptoms. The study included 65 traumatic brain injury patients of an average age of 76 years who were within three hours of trauma surgery service evaluation. Thirty-four patients received standard treatments for TBI plus 4 grams NAC within three hours of injury, followed by a 3-day period during which 2 grams NAC was administered twice per day and an additional 3 days during which 1.5 grams NAC was provided twice daily. The remainder of the participants received standard treatment alone. Questionnaires that evaluated post-concussion symptoms were administered at the beginning of the study and at 7 and 30 days. Questionnaire scores were significantly better in the NAC group on days 7 and 30.

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Ozone antiseptic shows potential for treating severe gum infections

Research SEA (Japan)

A powerful new antiseptic agent, called ozone nanobubble water, holds promise for the treatment of periodontitis, or severe gum infections, according to research published in the journal Science and Technology of Advanced Materials. The study, by Professor Shinichi Arakawa and colleagues, evaluated the bactericidal activities of ozone nano-bubble water — also known as NBW3 — against the two main bacterial agents that cause periodontitis. It also assessed NBW3’s toxicity to human oral tissue cells. Their results showed that NBW3 can kill periodontal pathogens within 30 seconds of exposure, yet has only a minor impact on the viability of oral tissue cells after 24 hours of exposure. Based on their in vitro results, the researchers conclude that NBW3 could become a valuable tool for treating periodontitis.

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Eating a Mediterranean diet could cut womb cancer risk

Institute of Pharmacological Research (Italy)

Women who eat a Mediterranean diet could cut their risk of womb cancer by more than half (57 per cent), according to a study published in the British Journal of Cancer*. The Italian researchers looked at the diets of over 5,000 Italian women to see how closely they stuck to a Mediterranean diet and whether they went on to develop womb cancer**. The team broke the Mediterranean diet down into nine different components and measured how closely women stuck to them. The diet includes eating lots of vegetables, fruits and nuts, pulses, cereals and potatoes, fish, monounsaturated fats but little meat, milk and other dairy products and moderate alcohol intake. Researchers found that women who adhered to the Mediterranean diet most closely by eating between seven and nine of the beneficial food groups lowered their risk of womb cancer by more than half (57 per cent). Those who stuck to six elements of the diet’s components reduced their risk of womb cancer by 46 per cent and those who stuck to five reduced their risk by a third (34 per cent). But those women whose diet included fewer than five of the components did not lower their risk of womb cancer significantly.

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Regular chocolate consumption may be linked to lower risk of heart flutter

Harvard and Alborg (Denmark) universities,

Regular chocolate consumption may be linked to a lower risk of developing the heart rhythm irregularity atrial fibrillation, also known as heart flutter, finds research published online in the journal Heart. The associations seemed to be strongest for 1 weekly serving for women and between 2 and 6 weekly servings for men, the findings suggest. They drew on 55,502 (26,400 men and 29,100 women) participants, aged between 50 and 64, from the population-based Danish Diet, Cancer and Health Study. Participants provided information on their usual weekly chocolate consumption, with one serving classified as 1 ounce (30 g). But they were not asked to specify which type of chocolate they ate. Most chocolate eaten in Denmark, however, is milk chocolate (minimum 30 per cent cocoa solids). When the data were analysed by sex, the incidence of atrial fibrillation was lower among women than among men irrespective of intake, but the associations between higher chocolate intake and lower risk of heart flutter remained even after accounting for potentially influential factors. The strongest association for women seemed to be 1 weekly serving of chocolate (21 per cent lower risk), while for men, it was 2 to 6 weekly servings (23 per cent lower risk).

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Fruit and vegetable consumption and risk of lung cancer

Qingdao University (China)

According to news reporting originating in Shandong, People's Republic of China, A meta-analysis was conducted to summarize evidence from prospective cohort studies about the association of fruit and vegetable consumption with the risk of lung cancer. A random-effects model was used to combine study-specific relative risks and 95% confidence interval. Dose-response relationship was assessed by restricted cubic spline. The RR (95% CI) of lung cancer for highest versus lowest category of fruit and vegetable (FV) consumption was 0.87 (8 studies including 12,942 cases among 1,571,494 subjects), and the effect was 0.84 for fruit (16 studies including 15,421 cases among 1,791,469 subjects) and 0.90 for vegetable (19 studies including 16,422 cases among 1,877,375 subjects).

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Going For A 10-Minute Power Walk Every Day Could Be Secret To Long Life

National Cancer Institute

Could a 10-minute power walk every day could add years to your life? A recent study of nearly 5,000 older adults found that deaths fell as physical activity increased. Just 10, 20, or 30 minutes extra exercise a day per day reduced annual mortality rates by seven, 13 and 17 percent respectively. The research is based on Americans aged 40 to 85 who wore accelerometers on their waist for a week. Volunteers were tracked for an average of ten years, during which time 1,165 deaths occurred. The study shows that adding 10 minutes of physical activity each day resulted in an estimated 111,174 preventable deaths per year. Not surprisingly, the more physical activity, the more deaths prevented. The number almost doubled and tripled to 209,459 and 367,037, respectively, for 20 and 30 minutes. Similar results were observed for men and women, including those of all ethnic backgrounds.

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Whey protein improves blood glucose in diabetics

Newcastle University (UK),

A study reported in BMJ Open Diabetes Research & Care resulted in improved glucose control among people with type 2 diabetes who consumed whey protein. The crossover study included 18 type 2 diabetic men and women who received a drink that contained 15 grams of whey protein or a protein-depleted placebo to be consumed 10 minutes before breakfast, lunch and dinner for 7 days. This was followed by a 2-week period during which no treatments were given. Participants who had previously received whey were then given a placebo and those who received the placebo were given whey for an additional 7 days. Continuous glucose monitoring revealed improved daily blood glucose levels in association with whey intake. Participants experienced an increase of 2 hours per day of normal glucose during the week in which whey was consumed in comparison with the week in which the placebo was administered.

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Antioxidants from grape powder helped ease hyperglycaemia-related cognitive dysfunction in aged rats, a study discovered.

Researchers from the Taipei Medical University said polyphenols from grape powder produced antioxidative and blood sugar-lowering properties that reduced the damage caused by a high-fat-high-fructose (HFHF) diet.

Findings revealed that 6% grape powder group had reduced RAGE, or receptor for advanced glycation end products in the brain tissue.

“Inclusion of up to 6% grape powder in the diet markedly reduced RAGE expression and tau hyperphosphorylation, but upregulated the expression of Nrf2 and BDNF, as well as the phosphorylation of PI3K and ERK, in the brain tissues of aged rats fed the HFHF diet,” the researchers reported.

Thus, while long-term diet high in fructose and fat levels can cause hyperglycemia-related cognitive dysfunction in aged rats, grape powder supplementation can help ease the damaging changes in the brain protein related to neurodegeneration.

Medical University of South Carolina, May 24, 2022

While most commonly known as “the powerhouses of the cell” because of their energy producing capabilities, mitochondria also play important roles in regulating the health of cells. These important structures can be damaged by alcohol consumption, which can cause them to rupture and release their DNA, proteins and lipids, collectively known as “damage associated molecular patterns (DAMPs).”

To understand more fully how alcohol damages mitochondria, and how this leads to mitophagy, researchers at the Medical University of South Carolina (MUSC) used an advanced imaging technique to investigate changes in mitochondrial function within the livers of mice that were exposed to alcohol. Their findings, published online on March 16 in the journal Autophagy, demonstrated that exposure to alcohol causes a specific type of mitochondrial damage called depolarization. In a completely novel discovery, they found that it is this depolarization that indicates to the cell that the mitochondria are damaged and thereby causes activation of the mitophagy machinery to remove the damaged mitochondria before they can cause harm.

The current study determined that mitochondrial injury, specifically depolarization, initiates mitophagy to prevent damaged mitochondria from accumulating in cells. Blocking depolarization after ethanol exposure also blocks mitophagy, preventing mitochondrial depletion.

Johns Hopkins School of Public Health, May 22, 2022

Previous research has shown that the plant-produced chemicals known as flavonoids have beneficial antioxidant and anti-inflammatory properties. Anthocyanins, the type of flavonoid investigated in the current study, have been detected in lung tissue shortly after being ingested, and in animals models of chronic obstructive pulmonary disease (COPD). The plant chemicals appear to reduce mucus and inflammatory secretions.

The researchers analyzed data from 463 adults (average age: 44) who participated in the second and third European Community Respiratory Health Surveys from 2002 to 2012.  The researchers also analyzed the association between anthocyanin consumption and lung function in smokers, those who had never smoked and those who quit. The association between high consumption of the flavonoids and reduced lung function decline appeared to be stronger among both never smokers and those who had quit than in the general study population. Among smokers, the study did not find an association between anthocyanin intake and lung function.

“Our study suggests that the general population could benefit from consuming more fruits rich in these flavonoids like berries, particularly those who have given up smoking or have never smoked, Dr. Larsen said. 

Florida International University, May 24, 2022

For decades, most physicians, parents and teachers have believed that stimulant medications help children with attention deficit hyperactivity disorder (ADHD) learn. However, in the first study of its kind, researchers found medication has no detectable impact on how much children with ADHD learn in the classroom.

Approximately 10% of children in the U.S. are diagnosed with ADHD and more than 90% of them are prescribed stimulant medication as the main form of treatment in school settingsbecause most physicians believe that medication will result in better academic achievement.

Researchers evaluated 173 children between the ages of 7 and 12 with ADHD participating in the center’s Summer Treatment Program, a comprehensive eight-week summer camp program for children with ADHD and related behavioral, emotional and learning challenges.  Each child was randomized to be medicated with a sustained-release stimulant medication during either the first or second of the instructional phases, receiving a placebo during the other.

Contrary to expectations, researchers found that children learned the same amount of science, social studies, and vocabulary content whether they were taking the medication or the placebo.

NYU School of Medicine May 21, 2022

Eating a Mediterranean diet may protect people from some of the harm of long-term exposure to air pollution, and reduce their risk of dying from heart attacks, stroke and other causes of death, according to new research.

The researchers analyzed data from the National Institutes of Health (NIH)-American Association of Retired Persons (AARP) Diet and Health Study. Over 17 years, the study followed 548,699 people (average age 62 at enrollment) from 6 states. During that time, 126,835 people in the study group died.

The researchers created five groups of participants based on their level of adherence to a Mediterranean diet and linked participants to estimates of long-term exposure to fine particulate matter (PM2.5), nitrous oxide (NO2) and ozone (O3) based on census tract information.

When comparing those least and most adherent to a Mediterranean diet, the study found that:

• Deaths from all causes increased by 5 percent for every 10 parts per billion (ppb) increase in long-term average NO2 exposure in those least adherent, compared to 2 percent among the most adherent.

Consuming broccoli may change the diversity and composition of the microbiota in the gastrointestinal tract, says a new study.

Two hundred grams per day of broccoli for 17 days resulted in 37% increase in the proportion of Bacteroidetes relative to Firmicutes, according to data presented at the Experimental Biology meeting in Chicago this week by scientists from the University of Illinois at Urbana-Champaign, ARS-USDA, and the National Cancer Institute.

“These novel results reveal that broccoli consumption affects the diversity and composition of the GI microbiota of healthy adults,” they wrote in the FASEB Journal . “These data help fill the gap in knowledge related to the role of bacterial hydrolysis of phytonutrients.

“The increase in Bacteroides spp. is particularly relevant because Bacteroides thetaiotaomicron has been shown in vitro to utilize glucosinolates.”

University of York

Researchers have found evidence that acupuncture could help people who experience dental anxiety.

Dental anxiety affects up to an estimated 30% of the adult population in countries world-wide. Patients can experience nausea, difficulty breathing and dizziness at the thought of going to the dentist, during an examination, and following treatment.

In a review of six trials with 800 patients, researchers used a points scale to measure anxiety and studies show that anxiety reduced by eight points when dental patients were given acupuncture as a treatment. This level of reduction is considered to be clinically relevant, which means that acupuncture could be a possibility for tackling dental anxiety.

Studies that compared anxiety levels between patients that received acupuncture and those that did not, showed a significant difference in anxiety scores during dental treatment. A clinically relevant reduction in anxiety was found when acupuncture was compared with not receiving acupuncture.

Case Western University

An article published in the Journal of the American College of Cardiology reported a protective effect for supplementation with omega-3 fatty acids against some of the harmful cardiovascular effects of exposure to air pollution in China.

The randomized, double-blinded trial included 65 healthy college students in Shanghai, China who received 2.5 grams fish oil as a source of omega-3 fatty acids or a placebo daily. During the last two months of the trial, the subjects participated in four health examinations that included blood pressure assessment and measurement of blood markers of inflammation, coagulation, endothelial function, oxidative stress, antioxidant activity, cardiometabolism and neuroendocrine stress response.

Campus levels of fine particulate matter air pollution (PM 2.5) measured during the course of the trial averaged 38 micrograms per cubic meter. The researchers observed greater stability of most biomarker levels in responses to changes in fine particulate matter exposure in the fish oil-treated group in comparison with the placebo group. Omega-3 fatty acid supplementation was associated with beneficial effects for five blood biomarkers of inflammation, coagulation, endothelial function, oxidative stress, and neuroendocrine stress response. 

Umea University (Sweden)

The recurrent vibrations caused by snoring can lead to injuries in the upper airways of people who snore heavily. This in turn, can cause swallowing dysfunction and render individuals more vulnerable for developing the severe condition obstructive sleep apnea. These findings are reported by researchers at Umeå University, Sweden. Their on-going research focuses on the processes behind vibratory damage and healing of the upper airway tract. The data generated will help identify people at high risk of developing sleep apnea and to find novel treatment strategies.

Researchers in Umeå have shown that snorers and sleep apnea patients have neuromuscular injuries in the upper respiratory tract. The injuries can be seen at both the structural and molecular level. Researchers could also observe a correlation between snoring and swallowing dysfunction as well as a relation between nerve damage and obstructive sleep apnea. Sleep apnea is characterized by repeated collapse of the upper respiratory tract leading to respiratory arrest during sleep, which increases the risk of cardiovascular disease.

The studies show that people who constantly snore heavily and have sleep apnea displayed a loss of nerves and muscle mass in the soft palate. Furthermore, the attempts by the body to heal damaged tissue were disturbed resulting in an abnormal muscle structure. Another interesting finding was that muscle fibres in the soft palate lacked or had a disturbed organization of certain structural proteins. These proteins stabilize the organelles of the muscle cell and support cellular structures related to energy production and muscle fibre contraction.

The researchers also found that a neurotransmitter that is normally associated with healing and regeneration of neurons was present in the muscle cells. This finding suggests that the body is trying to heal the injuries, but the recurrent snoring vibrations prevent proper healing. It becomes a vicious circle where snoring causes damage and at the same time disturb healing of injuries, which can lead to swallowing dysfunction and sleep apnea.

Zhei-jian Hospital (China)

Researchers from Zhejiang Hospital in China reported that practicing t’ai chi can help with hypertension. 

• The treatment group practiced simplified t’ai chi for three months. On the other hand, the control group underwent general daily lifestyle intervention.

State University of Maringa (Brazil)

A study published in The American Journal of Chinese Medicine found that the essential oil extracted from lemongrass (Cymbopogon citratus) can protect the liver from damage caused by acetaminophen intake. 

• They pretreated mice with 125, 250, or 500 milligrams per kilogram (mg/kg) of lemongrass essential oil or 200 mg/kg of a standard drug per day for seven days.

Want to escape Alzheimer’s disease? Run for your life and exercise

Tel Aviv Sourasky Medical Center (Israel), May 20, 2022



Exercise slows down aging of the brain and can reduce risks of Alzheimer’s disease and other dementias by about half.





 Long-term epidemiological and physical studies show that exercise can improve memory, concentration and mood and minimize pain, as well as reduce the risk of cognitive damage, stroke, Parkinson’s disease and depression.


“These findings flew in the face of the belief that over the age of 30, the neurons decline irreversibly. Today we know that the adult brain has many stem cells that when stimulated can differentiate and turn into ripe neurons that know how to create synapses.” The neurologist added that for some unknown reason, the best potential for differentiation exists in brain regions responsible for memory.


Exercise promotes the secretion of trophic factors — including brain-derived neurotrophic factor that encourage the growth of stem cells that turn into adult nerve cells. he added. These factors activate genes responsible for the development of stem cells in the hippocampus and other brain regions involved in memory, storage and processing of data. They are available in large quantities during a baby’s first years when the brain develops at a rapid pace, but the amounts decline during adolescence and aging.


It was best to do aerobic exercise (causing the heart and lungs to exert themselves) along with non-aerobic exercise (strengthening the muscles on the skeleton) at least three times a week. Even if you exercise just as an adult and the cognitive decline has begun, your physical activity will slow down the rate of decline.


Orange juice is good for ageing brain: Study

University of Reading (UK) May 19, 2022

Drinking orange juice could help improve brain function in elderly people, says a new study.

The study saw a group of 37 healthy adults (mean age 67 years) consuming 500 ml of orange juice daily over an eight week period. At the beginning and end of the eight weeks their memory, reaction time and verbal fluency was measured. 

This study is thought to be one of the first to show that regularly consuming orange juice flavanones could have a positive effect on older people’s cognition. 

“This is an important discovery which strengthens the growing body of evidence that flavonoid rich foodstuffs could play a big role in tackling cognition decline in old age,” he concluded. 

Oil Pulling For Maintaining Oral Hygiene – Review

Yenepoya University and Dental College (India), May 22, 202

Oil pulling is an ancient ayurvedic therapy for maintaining oral hygiene. Oils for oil pulling are easily available in household. Oil pulling is mentioned in the ayurvedic text Charak Samhita and Sushruta Samhita as ‘Kavala Graha’ or ‘Kavala Gandoosha’.  In Gandoosha the mouth is completely filled with oil such that gargling is impossible whereas in Kavala Graha comfortable lesser quantities of oil is used such that gargling is possible.

In oil pulling, a tablespoon full of oil is swished around the mouth in the early morning before breakfast and in empty stomach for about 20 min. In case of children greater than five years of age, a teaspoon of oil is used. The oil is ‘pulled’ and forced in between all the teeth by swishing it all around the mouth. At the end of this activity if the procedure is done correctly, the viscous oil will become milky white and thinner. Then it is spit out and mouth is thoroughly washed with clean warm saline water or tap water and teeth are cleaned with fingers or routine tooth brushing is performed.9 If the jaw aches, then the procedure can be done just for 5–10 min. The oil should not be spit into the sink as the oil can cause clogging of the pipes. Instead, the oil should be spit into a trashcan or on a paper towel.

Oil pulling should be ideally performed daily morning on empty stomach before brushing teeth and care should be taken that oil is not swallowed. Swallowing of oil during oil pulling should be avoided as the oil contains bacteria and toxins. Oil pulling is best practiced in sitting position with chin up. It can be practiced thrice daily in empty stomach before meals to fasten the healing effects. It is contraindicated for children below 5 years due to risk of aspiration. The practitioner should take care not to aspirate the oil while performing rigorous oil pulling. In cases of oral ulcers, fever, vomiting tendency, asthma and in conditions where brushing is difficult and sometimes contraindicated, oil pulling can be advantageously used to maintain oral hygiene.

Organic oils such as sunflower oil, sesame oil, and coconut oil are of benefit especially if it is cold pressed, though refined oil also works in “pulling” the bacteria, viruses and protozoa from the oral cavity. Since trans fats are absent in cold pressed oils when compared to commercial oils which are extracted from strong petroleum based solvents; oil pulling is ideally performed with cold pressed oils.

Oil pulling generates antioxidants which damage the cell wall of microorganisms and kill them. These oils will attract the lipid layer of bacterial cell membranes, and cause it to stick or get attracted, and pulled to the oil. During oil pulling, the oil gets emulsified and surface area of the oil gets increased.

Paracetamol (Tyenol) in pregnancy may lower testosterone in unborn boys

University of Edinburgh, May 20th, 2022

Prolonged paracetamol use by pregnant women may reduce testosterone production in unborn baby boys, research has found.

Researchers say their findings could help to explain reported links between paracetamol use in pregnancy and reproductive health problems in young boys.

The University of Edinburgh study tested the effect of paracetamol on testosterone production in mice that carried grafts of human testicular tissue. These grafts have been shown to mimic how the developing testes grow and function during pregnancy.

Scientists gave the mice a typical daily dose of paracetamol – over a period of either 24 hours or seven days. They measured the amount of testosterone produced by the human tissue an hour after the final dose of paracetamol.

They found there was no effect on testosterone production following 24 hours of paracetamol treatment. After seven days of exposure, however, the amount of testosterone was reduced by 45 per cent.

Natural plant chemicals in licorice root could help fight tooth decay, study shows

University of Edinburgh (Scotland), May 20, 2022

Oral care products containing a natural chemical that stops bacteria harming teeth could help prevent decay, a study suggests.

The plant natural product acts against harmful mouth bacteria and could improve oral health by helping to prevent the build-up of plaque, researchers say.

The compound – known as trans-chalcone – is related to chemicals found in liquorice root. The study shows that it blocks the action of a key enzyme that allows the bacteria to thrive in oral cavities.

Researchers found that blocking the activity of the enzyme prevents bacteria forming a protective biological layer – known as a biofilm – around themselves. Plaque is formed when bacteria attach themselves to teeth and construct biofilms. Preventing the assembly of these protective layers would help stop bacteria forming plaque, the teams says.

Another Practice That Helps Gut Disease: Yoga, Meditation and Prayer, Says Study

Benson-Henry Institute at Massachusetts General Hospital, May 19, 2022 

A pilot study has found that participating in a nine-week training program including elicitation of the relaxation response (mind body stress reduction techniques such as yoga, meditation and prayer) had a significant impact on clinical symptoms of the gastrointestinal disorders irritable bowel syndrome and inflammatory bowel disease and on the expression of genes related to inflammation and the body’s response to stress. These practices actually have a tangible effect on genes!

 The report  is the first to study the use of the relaxation response in these disorders and the first to investigate the genomic effects of the relaxation response in individuals with any disorder.


The current study was designed both to investigate whether a relaxation-response-based intervention could improve the quality of life in patients with IBS or IBD and to analyze the intervention’s effects on inflammatory markers and gene expression. The study enrolled 48 adult participants – 19 of whom had been diagnosed with IBS and 29 diagnosed with IBD – who participated in a nine-week group program focused on stress reduction, cognitive skills and health-enhancing behaviors. Each of the weekly sessions included relaxation response training, and participants were asked to practice relaxation response elicitation at home for 15 to 20 minutes each day. Along with aspects featured in other group programs offered at the Benson-Henry Institute, this program included a session specifically focused on gastrointestinal health.

Both in patients with IBS and those with IBD, participation in the mind/body program appeared to have significantly improved disease-related symptoms, anxiety and overall quality of life, not only at the end of the study period but also three weeks later. While there were no significant changes in inflammatory markers for either group of participants, changes in expression were observed in almost 200 genes among participants with IBS and more than 1,000 genes in those with IBD. Many of the genes with altered expression are known to contribute to pathways involved with stress response and inflammation.

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An aqueous extract of caraway seeds may suppress appetite and help slim waistlines and thighs in physically active women, says a new study.

Data published in Phytotherapy Research indicated that 90 days of supplementation with the caraway (Carum carvi L.) extract led to significant reductions in waist circumference of 6.2 cm and thigh circumference of 5.4 cm, compared to baseline levels. No significant waist reductions were recorded in the placebo group.

“This study showed that the consumption of 30 mL/day CAE [caraway aqueous extract] may result in reasonable anti-obesity effects,” wrote the researchers. “Most likely, this occurs through a combination of four major bioactivities, including anti-microbial, anti-oxidant, and anti-inflammatory properties, together with the appetite-suppressing activity.

Scientists from the University of Malaya (Malaysia), Shahid Beheshti University of Medical Sciences (Iran), and Natural Products Inc (USA) recruited 70 aerobically trained, overweight, and obese women to participate in their triple-blind, placebo-controlled, clinical study. The women – who were instructed to not change their diet or physical activity – were randomly assigned to receive either the caraway extract or placebo for 90 days.

Results showed that women in the caraway group had significant reductions in both appetite levels and carbohydrate intake compared with the placebo group.

Commenting on the potential bioactives compounds responsible for the effects, the researchers note that caraway seed extracts contain volatile compounds such as limonene, gamma-terpinene, trans-carveol, carvone, thymol, and carvacrol.

Oxford University

Recent studies have explored the science behind friendships and discovered that there are actually measurable differences between people who have strong, healthy social networks and those who don’t. In particular, people with strong friend connections were found to experience significantly better states of physical and mental health.

“People with social support have fewer cardiovascular problems and immune problems, and lower levels of cortisol — a stress hormone,” says Tasha R. Howe, PhD, associate professor of psychology at Humboldt State University.

Adding to the growing research on the benefits of friendship, a recent study conducted by researchers at Oxford University established that people with more friends have higher pain tolerance. 

The study was designed to use pain tolerance to test the brain’s endorphin activity. The researchers theorised that people with larger social networks would, as a result, have higher pain tolerance. The findings of the study supported their theory in that it showed that indeed, strong social connections were correlated with higher pain tolerance.

As mentioned in the final statement it is not just the size of our social network that is important to our wellbeing, but the quality of the friendships that matters as well. With the advent of the internet modern society is changing quickly, and our interactions are increasingly occurring online. Even though the internet can be a great way to connect with likeminded people, online friends just aren’t the same as those we can actually sit with and look directly in the eye when we communicate–and a digital hug is just nowhere near as good as a real one! 

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