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Antioxidants may reduce oxidative stress in men with prostate cancer

Universities of Connecticut, Louisiana State, North Carolina, South Carolina, and California , November 3, 2022

This latest paper – which looked at men with prostate cancer from the North Carolina-Louisiana Prostate Cancer Project – came in light of a growing body of evidence suggesting oxidative stress plays a role in the development and progression of prostate cancer. The researchers looked at biomarkers of oxidative stress in the blood, urine and prostate tissue. 

They found a greater antioxidant intake was associated with lower urinary 8-isoprostane concentrations. 

A 10% increase in antioxidant intake saw an unadjusted 1.1% decrease in urinary 8-isoprostane levels. 

8-Isoprostane has been described as a “reliable marker”  and recognised  “gold standard” for lipid peroxidation – the oxidative degradation of lipids. 

“This study demonstrated that intake of antioxidants was associated with less oxidative stress among men with incident prostate cancer,” the researchers concluded in the British Journal of Nutrition.   

“The results of this study and others warrant additional research in humans on the mechanisms underlying the relationship between dietary antioxidants and prostate tissue redox status and carcinogenesis, as well as determining whether this relationship may influence disease severity, progression and recurrence.” 

High-intensity exercise changes how muscle cells manage calcium 

Karolinska Institute (Sweden) November 2, 2022

Researchers at Karolinska Institutet in Sweden have discovered a cellular mechanism behind the surprising benefits of short, high-intensity interval exercise. Their findings, which are published in the scientific journal PNAS, also provide clues to why antioxidants undermine the effect of endurance training. 

A few minutes of high-intensity interval exercise is enough to produce an effect at least equivalent to that achieved with traditional much more time-consuming endurance training. High-intensity exercise has become popular with sportspeople and recreational joggers alike, as well as with patients with impaired muscle function. However, one question has so far remained unanswered: how can a few minutes’ high-intensity exercise be so effective?

To investigate what happens in muscle cells during high-intensity exercise, the researchers asked male recreational exercisers to do 30 seconds of maximum exertion cycling followed by four minutes of rest, and to repeat the procedure six times. They then took muscle tissue samples from their thighs.

“Our study shows that three minutes of high-intensity exercise breaks down calcium channels in the muscle cells,” says Professor Håkan Westerblad, principal investigator at Karolinska Institutet’s Department of Physiology and Pharmacology. “This causes a lasting change in how the cells handle calcium, and is an excellent signal for adaptation, such as the formation of new mitochondria.”

Mitochondria are like the cell’s power plants, and changes that stimulate the formation of new mitochondria increase muscle endurance. What the researchers found was that the breakdown of calcium channels that was triggered by the high-intensity exercise was caused by an increase in free radicals, which are very reactive and oxidise cellular proteins.

The cells therefore have antioxidative systems for trapping and neutralising the radicals. Antioxidants, like vitamins E and C, are also present in food and are common ingredients in dietary supplements. In the present study, the researchers examined what happens when isolated mouse muscles are treated

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Study shows eating prunes daily can help prevent bone lossPenn State University, November 3, 2022

People often eat prunes to boost their digestive health, but a study published in the American Journal of Clinical Nutrition shows that consuming a handful of prunes a day may also help prevent bone loss when you are older.

Researchers from Penn State University reported that women in their 60s who consumed prunes had significantly less bone loss in their hips in a year compared to those who didn’t eat the dried fruits. This suggests that prunes can help reduce inflammation in the body, which is a key driver of bone loss.

The researchers recruited 235 women for the study. The volunteers had an average age of 62 and had already gone through menopause.

The participants were split into three equal groups:

One group didn’t consume prunes.Another group consumed at least 50 grams (g) of prunes a day, or four to six pieces daily.The last group consumed 100g of prunes, or 10 to 12 pieces daily.The volunteers ate the “Improved French” prune variety. All of their diet included calcium and vitamin D3 supplements, which can also help prevent bone loss.

The research team used scans to measure bone density in the hip, neck and hip socket at the start of the study, after six months and after one year. They found that the hips of the non-eaters had an estimated 1.1 percent loss of bone density a year after the study began.

Meanwhile, the bone density of those who consumed four to six prunes a day barely shifted.

The result was similar for the group that ate more prunes, but the researchers noted that any protective effect could be masked because of its much higher dropout rate.

Blood tests also showed that the women who consumed prunes had significantly lower inflammation levels than those who did not. There was no significant documented difference in bone mass in the spine or hip socket between the groups one year after the study began.

Tracing tomatoes’ health benefits to gut microbesOhio State University, November 7, 2022

Two weeks of eating a diet heavy in tomatoes increased the diversity of gut microbes and altered gut bacteria toward a more favorable profile in young pigs, researchers found.

After observing these results with a short-term intervention, the research team plans to progress to similar studies in people, looking for health-related links between tomatoes in the diet and changes to the human gut microbiome – the community of microorganisms living in the gastrointestinal tract.

“It’s possible that tomatoes impart benefits through their modulation of the gut microbiome,” said senior author Jessica Cooperstone, assistant professor at The Ohio State University.

The tomatoes used in the study were developed by Ohio State plant breeder, tand co-author David Francis, and are the type typically found in canned tomato products.

Ten recently weaned control pigs were fed a standard diet and 10 pigs were fed the standard diet fine-tuned so that 10% of the food consisted of a freeze-dried powder made from the tomatoes.

Fiber, sugar, protein, fat and calories were identical for both diets. The control and study pig populations lived separately, and researchers running the study minimized their time spent with the pigs – a series of precautions designed to ensure that any microbiome changes seen with the study diet could be attributed to chemical compounds in the tomatoes.

Results showed two main changes in the microbiomes of pigs fed the tomato-heavy diet – the diversity of microbe species in their guts increased, and the concentrati

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Zinc supplementation associated with higher levels of brain growth factorSoybean foods may protect menopausal women against osteoporosis Study finds diet high in saturated fat can reprogram immune cells in miceCoenzyme Q10 consumption reverses cholesterol transportStudy confirms that processed foods key to rising obesityViolence on TV: Effects from age 3 can stretch into the teen years

Zinc supplementation associated with higher levels of brain growth factor

Iran University of Medical Sciences, November 4 2022. 

A review and meta-analysis of randomized, controlled trials affirmed an association between supplementing with zinc and higher circulating levels of brain-derived neurotrophic factor (BDNF). Brain-derived neurotrophic factor plays a positive role in the survival of brain cells known as neurons. A reduction in BDNF expression occurs in Alzheimer and Parkinson diseases, multiple sclerosis and amyotrophic lateral sclerosis. Antidepressants and anthocyanin supplements have been shown to increase BDNF gene expression, and serum or plasma levels have been elevated by exercise and omega-3 fatty acid, resveratrol or zinc supplementation.

For their review and meta-analysis, Fahimeh Agh of Iran University of Medical Sciences and colleagues identified four trials that evaluated the effects of zinc supplements on serum or plasma BDNF levels among 185. Zinc dosages ranged from 25–30 milligrams per day given for 84–90 days. 

Pooled results of the trials found significantly higher BDNF levels among participants who received zinc compared with participants in the control groups. The increase in BDNF was significant at 30 milligram doses (which were used in 3 trials) and at all trial durations. Among the 3 trials that analyzed serum zinc levels, participants who were given zinc supplements had significantly increased zinc levels in comparison with the control participants. 

“A large body of evidence indicated BDNF as an important predictive factor for following the beginning, progress and cure of brain disorders due to its main role in brain neurogenesis and neuroplasticity,” Agh and her associates wrote. 

“Increased circulating levels of BDNF as a result of zinc supplementation suggest that zinc supplementation may be a safe and effective strategy to counteract neurodegenerative diseases that are correlated with low BDNF levels,” they concluded.

Soybean foods may protect menopausal women against osteoporosis 

University of Hull (UK), November 1, 2022

Eating a diet rich in both soy protein and isoflavones can protect menopausal women from bone weakening and osteoporosis, according to the results of a preliminary study presented today at the Society for Endocrinology annual conference in Edinburgh.

Soybean foods contain chemicals known as isoflavones that are similar in structure to oestrogen and so could theoretically protect women against osteoporosis by mimicking the action of oestrogen.

In this study, researchers from the University of Hull gave two hundred women in early menopause a daily supplement containing soy protein with 66mg of isoflavones or a supplement with soy protein alone for six months. The researchers investigated changes in the women’s bone activity by measuring certain proteins (βCTX and P1NP) in their blood. 

They found that the women on the soy diet with isoflavones had significantly lower levels of βCTX than the women on soy alone, suggesting that their rate of bone loss was slowing down and lowering their risk of developing osteoporosis. Women taking soy protein with isoflavones were also found to have decreased risk of cardiovascular disease than those taking soy alone.

“The 66 mg of isoflavone that we use in this study

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Study reveals the powerful pain-relieving properties of ashwagandha

Nizam Institute of Medical Science (India), October 30, 2022

People experiencing knee joint pain and discomfort, particularly those with knee osteoarthritis, may find relief in an Ayurvedic medicine called ashwagandha(Withania somnifera). A study published in the Journal of Ayurveda and Integrative Medicine found that the root and leaf extracts of ashwagandha relieve knee pain and discomfort caused by osteoarthritis.

In the search for safe and effective natural pain relief treatments, researchers from Nizam’s Institute of Medical Sciences (NIMS)  evaluated the efficacy and safety of the root and leaf extracts of ashwagandha in patients with knee joint pain and discomfort. Ashwagandha is known to contain analgesic, anti-inflammatory, and chondroprotective properties.

In the study, the researchers recruited 60 patients with knee joint pain and discomfort. These participants received placebo capsules, 125 milligrams (mg) of ashwagandha extract, or 250 mg of ashwagandha extract twice a day for 12 weeks.

The results revealed that participants who received doses of ashwagandha extracts experienced great reductions in pain, stiffness, and disability. Those who received the higher dose of ashwagandha, which was 250 mg, experienced even greater and faster effects than those who received the 125 mg dose. In addition, the ashwagandha treatment did not cause any side effect. Overall, both doses of ashwagandha extract caused significant reductions in pain, stiffness, and disability of patients in a dose-dependent manner without causing any side effect.Ashwagandha Root Supports Thyroid Hormone Levels

Sudbhawana Hospital (India), October 31, 2022

Eight weeks of supplementation with Ashwagandha root extract were associated with normalization of the thyroid stimulating hormones (TSH), serum thyroxine (T4) and serum triiodothyronine (T3) in people with elevated TSH levels.

“The results of the present study are in accordance with previous studies,” wrote the researchers in the Journal of Alternative and Complementary Medicine. “The results indicate a possible role for ashwagandha in regulating HPT axis. The anti-stress and cortisol-lowering effect of ashwagandha may provide a suitable explanation for the current outcome.”

Ashwagandha has been used traditionally as an adaptogen to rejuvenate health, maintain homeostasis, sustain normal thyroid function and maintain hormonal balance in human body. However, very few modern published papers have reported ashwagandha’s beneficial effects on thyroid function. This is the first clinical study that supports the traditional claim of ashwagandha as a thyroid modulator.

The new double blind, randomized, placebo-controlled study involved 50 people with elevated TSH levels. So called subclinical hypothyroidism is described as a thyroid disorder with no obvious symptoms of thyroid deficiency. Participants were randomly assigned to receive either ashwagandha supplements (600mg daily) or placebo for eight weeks.

Results showed that ashwagandha significantly improved serum TSH, serum T4 and serum T3 levels, achieving change toward normalization of 19%, 45% and 21% respectively.

“The outcome of the present study highlights the beneficial role of ashwagandha root extract for normalizing thyroid hormone levels in subclinical hypothyroid patients; however, further studies are required to elucidate the underlying mechanisms of ashwagandha,” concluded the researchers.

Enzyme in Broccoli, Cucumbers and Avocados Reverses Aging In Cells

Washington University School of Medicine

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Dietary supplement found to improve concentration levelsUniversity of Granada, November 3, 2022

The research group from the University of Granada (UGR) has tested the effects of a multi-ingredient dietary nootropic on concentration levels and cognitive performance. Nootropics are cognitive enhancers that have traditionally been used in the treatment of cognitive pathologies.

Leading this study was Lucas Jurado Fasoli—a researcher from the Scientific Unit of Excellence in Exercise, Nutrition and Health (UCEENS) at the Sport and Health Joint University Institute (iMUDS). He explains that, traditionally, nootropics have been drugs, with their corresponding side-effects.

“To address the issue of potential side-effects, different dietary nootropics have emerged as an alternative way to enhance cognitive performance. And these, as is the case in this study, are used by healthy individuals in activities such as preparing for competitive exams or video-game competitions,” explains Jurado Fasoli.

The results of the study showed that the acute intake of this multi-ingredient nootropic decreases the response time across different cognitive tests: in processing speed, inhibitory control, working memory, and cognitive flexibility. It also increases accuracy in tests involving processing speed, inhibitory control, and cognitive flexibility. The supplement contains L-tyrosine, acetyl L-carnitine, sodium citicoline, alpha-GPC, taurine, caffeine, mango leaf extract and huperzia serrata leaf.

These results were accompanied by an increase in positive emotions and a decrease in negative emotions and depression. And, importantly, the favorable effects of this nootropic did not appear to have any effect on the heart-rate of participants.

Previous studies have shown that supplementation with the combination of caffeine and taurine, L-theanine, tyrosine, and mango leaves extract can improve the RT in different cognitive and computerized tests. In this study, we showed that a dietary multi-ingredient nootropic improves the processing speed of information in young healthy adults. This effect could be due to the synergic effects of different dietary ingredients included in the nootropic. Also, it could be partially explained by the central nervous system activation and alertness enhancement effect of caffeine, which could increase the processing speed and decrease the RT. The inclusion of L-theanine as a dietary ingredient in the nootropic counteracts the potential effects derived from a high dose of caffeine on anxiety, psychological stress, blood pressure, and HR, which completely agrees with our results.

A sample comprising 26 young adults (50:50 male/female, with an average age of 25) participated in the study. They were required to undertake various cognitive tests twice, separated by 48 hours, having ingested either the multi-ingredient dietary nootropic or a placebo (randomized and triple-blinded across the sample).

Thirty minutes after ingestion, measurements were taken of processing speed, inhibitory control, working memory, cognitive flexibility, creativity, and verbal fluency. Different emotions were also evaluated and the participants’ heart-rate was recorded while they undertook the tests.

Consuming more magnesium associated with lower risk of mortality during years following heart attackWageningen University and Research (Netherlands), October 31, 2022

A study of people with a history of heart attack found that those who consumed more magnesium lived longer than those whose intake was low. Having a high magnesium intake, defined as greater than 320 milligrams (mg) per day, was associated with a 28% lower risk of dying from cardiovascular disease and a 22% lower risk of death from an

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Green tea and resveratrol reduce Alzheimer’s plaques in lab testsTufts University, November 2, 2022

Tufts researchers are working to understand what might slow progression of Alzheimer’s disease. They have tested 21 different compounds in Alzheimer’s-afflicted neural cells in the lab, measuring the compounds’ effect on the growth of sticky beta amyloid plaques. These plaques develop in the brains of people with Alzheimer’s.

The researchers found that two common compounds—green tea catechins and resveratrol, found in red wine and other foods—reduced the formation of plaques in those neural cells. And they did so with few or no side effects. The researchers reported their findings in the journal Free Radical Biology and Medicine.

Some of the 21 compounds tested reduced the disease progression by acting as anti-viral agents—slowing Alzheimer’s induced by the herpes virus. But finding a compound “that could diminish the plaques regardless of the virus component would be ideal, because that would show that regardless of the cause of Alzheimer’s, you might still see some kind of improvement,” says Dana Cairns, GBS12. Cairns is a research associate in the Kaplan Lab in the School of Engineering and led the research.

The initial screen found five compounds had “really robust prevention of these plaques,” she says. In addition to the green tea compounds and resveratrol, they found curcumin from turmeric, the diabetic medication Metformin, and a compound called citicoline prevented plaques from forming and did not have anti-viral effects.

“We hoped to find compounds that would be harmless and show some level of efficacy,” she said. Green tea compounds and resveratrol met that standard. “We got lucky that some of these showed some pretty strong efficacy,” Cairns said. “In the case of these compounds that passed the screening, they had virtually no plaques visible after about a week.”

The discovery is significant because there is no cure for Alzheimer’s or a way to prevent its progression, aside from several potential drugs developed by pharmaceutical companies that are still in trials, Cairns says. Compounds like these two that show some efficacy and are known to be safe and easily accessible could be taken as a supplement or consumed as part of one’s diet, she adds.

High fiber, yogurt diet associated with lower lung cancer riskVanderbilt University Medical School, October 28, 2022

A diet high in fiber and yogurt is associated with a reduced risk for lung cancer, according to a study by Vanderbilt University Medical Center researchers published in JAMA Oncology.

The benefits of a diet high in fiber and yogurt have already been established for cardiovascular disease and gastrointestinal cancer. The new findings based on an analysis of data from studies involving 1.4 million adults in the United States, Europe and Asia suggest this diet may also protect against lung cancer.

Participants were divided into five groups, according to the amount of fiber and yogurt they consumed. Those with the highest yogurt and fiber consumption had a 33% reduced lung cancer risk as compared to the group who did not consume yogurt and consumed the least amount of fiber.

“This inverse association was robust, consistently seen across current, past and never smokers, as well as men, women and individuals with different backgrounds,” she added. Shu said the health benefits may be rooted in their prebiotic (nondigestible food that promotes growth of beneficial microorganisms in the intestines) and probiotic properties. The properties may independently or synergistically modulate gut microbiota in a beneficial way.

Yoga Practice Beneficial to Patients With COPD

All India Institute of Medical Sciences Oct. 28, 2022

Patients with COPD

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Pycnogenol, gotu kola supplementation associated with decreased progression of atherosclerosisD’Annunzio University (Italy), October 23, 2022

The results of studies published in Minerva Cardioangiologica suggest a benefit for supplementation with extracts of pine bark and the herb gotu kola in atherosclerosis.

In one study, participants with arterial wall atherosclerotic lesions and intima-media thickening (thickening of the artery walls’ innermost layers) received standard management, standard management plus aspirin, or standard management, aspirin and Pycnogenol® pine bark extract plus gotu kola extract daily for three years, after which atherosclerotic lesion progression, carotid artery intima-media thickness and oxidative stress were assessed.

At the end of the trial, 5.3% of those who received Pycnogenol and gotu kola had experienced atherosclerotic lesion progression in comparison with over 20% of the remainder of the participants. Cardiovascular events that required hospital admission were less than 4% in the supplemented group compared to over 12% in the rest of the subjects. Carotid artery intima thickness and oxidative stress were also lower in association with supplementation.

In the second study, 90 men with coronary artery calcifications received standard management alone, standard management and daily Pycnogenol, or standard management with daily Pycnogenol plus gotu kola. All participants received daily aspirin. Calcification was assessed at the beginning of the study and after one year.

While Pycnogenol plus standard management was more effective than standard management alone, men who received Pycnogenol plus gotu kola experienced a 10% decline in the number of calcifications by the end of the study, in contrast with a 34.9% increase in the standard management group. “This indicates that supplementation with the combined supplements blocks the increase in calcified areas and, possibly, in time may decrease the number of calcified spots,” Shu Hu and colleagues write.

Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study.Pennsylvania State University, October 22, 2022Nut consumption lowers cardiovascular disease (CVD) risk. Studies are lacking about the effects of pistachios, a nutrient-dense nut, on CVD risk factors, dose-response relations, and lipid-lowering mechanisms.

We evaluated the effects of 2 doses of pistachios, added to a lower-fat diet, on lipids and lipoproteins, apolipoprotein (apo)-defined lipoprotein subclasses, and plasma fatty acids. To investigate the mechanisms of action, we measured cholesteryl ester transfer protein and indexes of plasma stearoyl-CoA desaturase activity (SCD).

In a randomized crossover controlled-feeding study, 28 individuals with LDL cholesterol > or = 2.86 mmol/L consumed 3 isoenergetic diets for 4 wk each. Baseline measures were assessed after 2 wk of a typical Western diet. The experimental diets included a lower-fat control diet with no pistachios [25% total fat; 8% saturated fatty acids (SFAs), 9% monounsaturated fatty acids (MUFAs), and 5% polyunsaturated fatty acids (PUFAs)], 1 serving/d of a pistachio diet (1 PD; 10% of energy from pistachios; 30% total fat; 8% SFAs, 12% MUFAs, and 6% PUFAs), and 2 servings/d of a pistachio diet (2 PD; 20% of energy from pistachios; 34% total fat; 8% SFAs, 15% MUFAs, and 8% PUFAs).

Inclusion of pistachios in a healthy diet beneficially affects CVD risk factors in a dose-dependent manner, which may reflect effects on SCD.

Poor quality sleep may be linked to heightened risk of glaucoma, irreversible sight lossSichuan University (China), November 1, 2022

Poor quality sleep, including too much or too li

Dr. Michael Hudson is one of our nation’s finest and most important economists and Wall Street financial analysts. Dr. Paul Craig Roberts has called Michael “the world’s best economist.” He is the President of The Institution for the Study of Long-Term Economic Trends, and a distinguished research professor of economics at the University of Missouri. He was the Chief Economic Policy Advisor for the Rep. Dennis Kucinich’s 2008 presidential campaign and has served as an adviser to the White House, State and Defense departments and served as an economic advisor to other governments including Iceland, Latvia and China.  Michael has written many books and important papers and articles. His most recent must-read book is "The Destiny of Civilization: Finance Capitalism, Industrial Capitalism or Socialism" which explains the reason for crisis in the US and other Western nations due to a drainage o income, indebtedness and a collapse of industrialization. His website is Michael-Hudson.com

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Almonds can help support the gut microbiome, study claimsKings College London, October 31, 2022A new study finds that eating 56 grams of almonds daily — the equivalent of approximately 46 almonds — can improve gut health by promoting levels of butyrate.The research involved three groups replacing their regular snacks with whole almonds, ground almonds, or an energy-equivalent control muffin.The authors conclude that incorporating almonds into the diet could be a way of increasing fiber intake without triggering gut symptoms.An important player in gut health appears to be butyrate, a short-chain fatty acid that supports the health of the microbiome itself.

Dr. Alice Creedon explained to Medical News Today: “Butyrate is important to gut health, as it acts as the primary source of fuel for the cells of the colon, allowing them to function correctly and optimally. It is also involved in signaling to the gut to initiate the process of nutrient absorption.”

“In addition,” said Dr. Creedon, “butyrate produced in the gut can enter the bloodstream where it is involved in the regulation of health in other areas of the body, such as the liver, brain, and lungs.”

The study demonstrates that eating a healthy handful of almonds each day promotes the production of butyrate.

Dr. Creedon’s research documents the benefits of eating about 56 grams, or 2 ounces, of almonds daily — that amounts to about 46 almonds.

“Butyrate supports the gut barrier, which keeps bacteria and other microbes from entering your blood. In doing so, butyrate can help to reduce inflammation, manage conditions like IBS [irritable bowel syndrome], and decrease gastrointestinal discomfort like bloating.

“Butyrate is produced through the fermentation of fiber in the colon. Therefore, increasing fiber in the diet, such as in almonds, increases butyrate levels, which has a positive effect on our gut health,” said Tallman.

Additional benefit of omega-3 fatty acids for the clearance of metabolites from the brain

Federation of American Societies for Experimental Biology, October 23, 2022

New research published online in The FASEB Journal suggests that omega-3 polyunsaturated fatty acids, which are found in fish oil, could improve the function of the glymphatic system, which facilitates the clearance of waste from the brain, and promote the clearance of metabolites including amyloid-β peptides, a primary culprit in Alzheimer’s disease.

To make this discovery, scientists first used transgenic fat-1 mice, which express high endogenous omega-3 polyunsaturated fatty acids (PUFAs) in the brain, to investigate the effect of omega-3 PUFAs on the clearance function of the glymphatic system. Compared to the wild-type mice, the fat-1 mice with enriched endogenous omega-3 PUFAs significantly promote the clearance function of the lymphatic system, including the Aβ clearance from the brain. Wild-type mice were supplemented with fish oil, which contains high concentrations of omega-3 PUFAs, and found that fish oil-supplemented mice also improved the clearance function of the glymphatic system compared to the control mice without fish oil supplementation. Omega-3 PUFAs help maintain the brain homeostasis, which may provide benefits in a number of neurological diseases, such as Alzheimer’s disease, traumatic brain injury, and sleep impairment, among others.

“These now-famous fatty acids have been the subject of major studies both in academia and industry. Just when we thought we had heard everything, here is something new, and it is provocative indeed,” said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. “This study should not turn attention away from the roles of these substances in maintaining vas

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Chlorophyllin shows promise for inflammatory bowel disease

Sichuan University (China) & Cedars Sinai Medical Center, October 28 2022. 

The August 2022 issue of the American Journal of Physiology Gastrointestinal and Liver Physiology reported research which found that supplementation with chlorophyllin suppressed intestinal inflammation in a mouse model of inflammatory bowel disease (IBD). 

Chlorophyllin is a water-soluble derivative of chlorophyll, the pigment that gives green plants their color. “Consuming green-colored vegetables or green pigment supplement such as chlorophyllin might help people with inflammatory bowel disease,” senior author Xiaofeng Zheng, PhD, of Sichuan University West China Hospital in Chengdu, China predicted. 

Current treatments for inflammatory bowel diseases include immunosuppressant medications and surgery, both of which are associated with potentially serious adverse effects. “The study was designed to determine the effect of safe agents that are easily available to have a beneficial effect in inflammatory bowel disease,” commented report coauthor Stephen J. Pandol, MD, of Cedars Sinai Medical Center in Los Angeles.

The team induced colitis in mice by administering dextran sulfate sodium. They found that supplementing the animals’ diets with chlorophyllin or directly administering the compound suppressed intestinal inflammation and downregulated disease-associated autophagy in the intestine. 

“What we found in the study was that the agent used, chlorophyllin, would inhibit the inflammation and tissue damage that occurs in an experimental model of colitis,” Dr Pandol commented. “In this case it was in a mouse model. The results were promising in an experimental model, and those can justify a clinical trial.”

Curcumin Prodrug Shows Promise As Cancer Treatment Without Toxic Side Effects

Kyoto University (Japan), October 30, 2022

Curcumin, the biologically active compound found in turmeric, has shown lots of promise in clinical cancer research. A new study from Kyoto University adds more evidence that supports its use in clinical-care settings. Researchers are developing a curcumin prodrug called TBP1901 that demonstrates anti-tumor effects without adverse toxicities.

Curcumin is an appealing compound for oncology researchers, as many current pharmacological treatments lead to significant side effects in patients. Thus far, anecdotal findings report strong efficacy when taken orally among cancer patients. However, until this recent development, curcumin’s low bioavailability and instability has put limitations on its clinical use.

Kanai and team have maneuvered their way around this by successfully identifying the enzyme GUSB, which may activate curcumin to increase its bioavailability. The enzyme plays a crucial role in TBP1901 conversion to curcumin. However, the research team hypothesized that the conversion wouldn’t be observable in mice with genetically-weakened GUSB enzyme.

Further, they were able to confirm through analysis with CRISPR-Cas9 screening that curcumin may also have additional specific therapeutic targets. “The high conversion rate of TBP1901 to curcumin in bone marrow warrants its clinical application for diseases growing in the marrow like multiple myeloma and leukemia,” states Kanai.

Now that scientists have begun to crack the code with curcumin, the cancer field may start to put things into motion as more targets and enzymatic processes are explained. 

Study Reveals How Turmeric Inhibits Pancreati