Dr RR Baliga's "Got Knowledge Doc" Podkast

The Genetics of GLP-1 Response 🧬💊📊


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Why do GLP-1 therapies transform some patients—and barely move the needle in others? 🧬💉

A recent Nature study (~28,000 participants) identifies GLP1R and GIPR variants linked to both weight loss efficacy and GI side effects.

📊 Signal: modest for weight loss, stronger for tolerability

🧠 Insight: genetics + clinical factors explain ~25% variability

🚀 Implication: early steps toward precision obesity therapeutics

The future may not be "one drug fits all," but one genome, one strategy.

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Dr RR Baliga's "Got Knowledge Doc" PodkastBy Dr RR Baliga, MD, MBA

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