It is thought that depression will be the single biggest cause of disability worldwide in the next 20 years; however, treatment for depression has not changed much in the last three decades. In his game-changing book, ‘The Inflamed Mind: A radical new approach to depression’, Professor Edward Bullmore reveals the breakthrough links found between depression and inflammation of the body and brain, representing a whole new way of looking at how mind, brain and body all work together. Here he discusses this fascinating book with Dr Raj Persaud and outlines a future revolution in the treatment of depression.