By AAI
The Journal of Immunology ImmunoCasts
Dr. Katherine Fitzgerald discusses a 2002 paper by Jürg Tschopp and colleagues that first defined the formation of the inflammasome complex.
Dr. Claudia Kemper discusses a 1985 PNAS paper that first identified CD46, a key regulatory molecule in the complement system.
Dr. Todd Fehniger discusses two seminal papers that demonstrated a role for IL-15 in the development and survival of natural killer cells.
Dr. Alberto Martin discusses A 1985 paper demonstrating that cancer could be caused by a non-mutated version of Myc
Dr. Craig Bassing discusses a 1993 Science paper by Frederick Alt that demonstrating a role for RAG2 in T cell development.
Dr. Shabaana Khader discusses a 2003 Nature paper by Daniel Cua that defined a specific role for IL-23 in autoimmune inflammation.
Drs. Bethany Moore and Steven Kunkel discuss a 1987 PNAS paper that first identified a chemotactic cytokine that would eventually be known as IL-8.
Dr. Dr. Mark Kaplan discusses a 1989 Science paper by Gerald Crabtree that demonstrated the mechanism by which cyclosporin A inhibited T cell activation.
Dr. Uttiya Basu discusses a 1999 paper by the group of Tasuku Honjo that demonstrates a critical role for activation-induced cytidine deaminase in class switch recombination and somatic hypermutation of B cells.
Dr. Luc van Kaer discusses a 1994 paper by the group of Dr. Don Wiley that demonstrated the binding of superantigens with the MHC class II molecule.
Dr. Martin Flajnik discusses a 2004 Nature paper by Drs. Max Cooper and Zeev Pancer that identified the existence of variable lymphocyte receptors that which were generated by non-RAG-based rearrangement events.
Dr. Wolf H. Fridman discusses a 2001 paper by the group of Robert Schreiber that established the foundations of modern immune-oncology.
Dr. Philippa Marrack discusses a 1994 Nature paper by Charles Surh and Jonathan Sprent that identified apoptotic cells in the thymus during positive and negative selection.
Dr. Dr. Jordan Orange discusses a 1994 Cell paper by Ute Francke that reported the discovery of the Wiskott Aldrich Syndrome Protein gene.
Dr. Wendy Havran discusses a 2001 paper by Adrian Hayday that demonstrates anti-tumor functions for skin-resident gamma delta T cells.
Dr. Eric Vivier discusses a 1999 paper by Thomas Spies that revealed a new mode of immune recognition via NKG2D on NK cells.
Dr. Marc Peters-Golden discusses a 1978 paper by Robert Murphy and Bengt Samuelsson that provided the first structural characterization of leukotriene C4.
Dr. Sebastian Amigorena discusses a 1994 paper by Sallusto and Lanzavecchia that made significant contributions to the field of dendritic cell biology.
Dr. Patricia Gearhart discusses a 1965 paper from Michael Potter and the Michael Potter Homogenous Immunoglobulin workshops held at the NIH.
Dr. James Hagman discusses a 1997 paper from the laboratory of Tak Mak, which first described the phenotype of T and B cells in mice lacking IRF4.
Dr. Jane Buckner discusses 1974 papers from Bottazzo and MacCuish that were instrumental in determining that autoantibodies are directed at pancreatic islet cells in type I diabetes.
Dr. Klaus Ley discusses Charles Mills’ 2000 article, published in The JI, describing the M1/M2 polarization axis of macrophages.
Dr. Pamela Schwartzberg discusses Cox Terhorst’s 1998 paper published in Nature that identified the gene encoding the SLAM protein SAP, which was later found to be mutated in X-linked proliferative syndrome.
Dr. Andrea Cooper discusses Ian Orme’s seminal work, published in 1987 in The JI, describing the kinetics, phenotype, and function of T cells responding to Mycobacterium tuberculosis.
Dr. Ranjan Sen discusses a 2000 article from the Krangel group that identified a chromatin-based mechanism for the regulation of V(D)J recombination.
Dr. Gabrielle Belz discusses a 1998 article from the Steinman group that revealed that monocytes could respond to a variety of cues, including non-cytokine cues, to differentiate into dendritic cells.
Dr. Reinhard Hohlfeld discusses a 1981 article describing the isolation and transfer of antigen-specific T lymphocytes capable of mediating autoimmune encephalomyelitis.
Dr. Glenn Dranoff talks about a 1984 article on the cloning of Granulocyte-Macrophage Colony Stimulating Factor.
Dr. Jiri Mestecky discusses a 1974 article in The JI on Per Brandtzaeg’s model for transport of secretory IgA.
Dr. Jeffrey Bluestone discusses three articles published in 2003 that describe the discovery of FOXP3 as the determinant of Treg cell fate and function.
Dr. Finkelman discusses two 1966 articles from The Journal of Immunology on the identification of IgE as the allergy-associated immunoglobulin isotype.
Dr. Michael Cancro speaks about a 1992 article describing the molecule (now termed CD154) that transduces the signal for Th-dependent B cell activation.
Dr. Kristen Hogquist discusses two of the most highly cited papers in the 100-year history of The Journal of Immunology, papers which describe the function or characterization of monoclonal antibodies to the human and mouse T cell receptors.
Dr. Gabriel Núñez speaks about a 1999 article by Shizuo Akira’s group which showed by both functional and genetic studies that TLR4 is the receptor for LPS.
Dr. Jay Kolls discusses three foundational articles published in The Journal of Immunology about the function of IL-10, two by Fiorentino and colleagues in 1991 and one by Steinbrink et al. in 1997.
Dr. Robert Fairchild discusses a 1983 article by Bass and coworkers on the use of flow cytometry in the intracellular analysis of NADPH oxidase function in human neutrophils.
Dr. Frank Fitch discusses a 1978 article describing an assay for T cell growth factor (later renamed IL-2) and its application in the study of lymphocytes.
Dr. Anne O'Garra talks about the 1997 work of Zheng and Flavell on the role of GATA-3 in Th2 cytokine gene expression in CD4 T cells.
Dr. Willi Born discusses two 1986 articles by Brenner and Bank and their colleagues, on the discovery of the gamma-delta T-cell receptor.
Dr. Diane Mathis speaks about work from Bruno Kyewski’s group on the role of thymic expression of peripheral tissue antigens in the induction of central tolerance.
Dr. Littman discusses work by Al Singer’s group on the “kinetic signaling” model of T cell lineage choice.
Dr. Unanue talks about about the work of Rudensky and colleagues on the sequence analysis of peptides bound to MHC class II molecules.
Dr. Gwen Randolph speaks about the seminal work of Reinhold Förster and colleagues on the role of CCR7 in the primary immune response.
Dr. Michael Krangel discusses an article from Mark Schlissel and colleagues that showed for the first time that chromatin structure determines the targeting of V(D)J recombinase activity.
Dr. Chandra Mohan discusses the 1994 article by Ward Wakeland and colleagues that described the chromosomal locations of genetic loci linked to murine lupus.
Dr. David Raulet talks about two 1971 articles by Cudkowicz and Bennett which examined rejection of allogeneic cells and the phenomenon of hybrid resistance.
Dr. Michael Gale speaks about the discovery in 1957 of type I interferon by Alick Isaacs and Jean Lindenmann.
Dr. Suzanne Cory discusses the 1999 publication that described how commitment to the B-lymphoid lineage depends on the transcription factor Pax5.
Dr. David Fox discusses a 1998 article by Schellekens et al. which showed that the amino acid citrulline was an essential component of the determinant recognized by anti-fillagrin autoantibodies in rheumatoid arthritis.
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