The Lab Report

Melatonin is known as the sleep hormone, but it is SO much more than that. Yes, it is produced in the brain and controls the day/night cycle. However, what many people don’t realize is that is also produced in other places in the body such as the gastrointestinal tract, skin, bone marrow, and more where it exerts important local effects that are important for health. Additionally, it is a powerful antioxidant making it crucial in mitigating harmful free radical damage which is implicated in aging and many chronic diseases.

In today’s episode, we break down the synthesis, physiology, and metabolism of melatonin. We discuss not only melatonin’s role in day/night cycles, but its important systemic effects to promote health and mitigate harmful risks.

Today on The Lab Report:

• 2:40 Melatonin is an important hormone
• 6:30 Break it down: melatonin and day/night cycles
• 9:00 Babies and sleep
• 10:30 Suprachiasmatic nucleus and blindness
• 11:30 Sleep, shift workers, jet lag 
• 14:30 Systemic antioxidant effects
• 16:10 Melatonin in the GI tract
• 17:40 Brain health, cancer, cardiovascular disease, and other hormones
• 21:00 Supplementation and side effects
• 23:25 Question of the Day
  • Does melatonin supplementation affect nutrition testing?

Additional Resources:

Comprehensive Melatonin Profile

One Day Hormone Check

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Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

See omnystudio.com/listener for privacy information.

If you’ve seen the Netflix documentary “The Social Dilemma,” you’ll recognize today’s guest. Dr. Anna Lembke is an addiction specialist from Stanford University, a New York Times best-selling author, and was featured on that Netflix special. Addiction takes many forms – not only alcohol and illicit drugs, but also social media, exercise, shopping, and workaholism. But, where’s the line between habit and addiction? What can we do to reset our brain chemistry?

In this episode, Dr. Lembke explains dopamine’s role in our brain’s reward system. We discuss addiction in its many forms, social media, and strategies to rewire dopamine pathways.

Today on The Lab Report:

• 3:00 Anna Lembke explains dopamine and the reward system  
• 6:05 Dopamine hits in today’s society
• 10:40 Moderation vs. Abstinence
• 13:30 Social media and children
• 15:00 Does society award addictive behavior?
• 18:45 Long term dopamine dysfunction and Parkinson’s disease
• 22:00 Parenting in the digital age
• 27:20 The Fireball

Additional Resources:

annalembke.com

Dopamine Nation

Drug Dealer, MD

The Social Dilemma

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Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

Dr. Sheila Dean is one of the nation’s premier integrative nutritionists. She is a co-founder of the Integrative and Functional Nutrition Academy and has practiced functional medicine for two decades. Her insight has not only changed the lives of many patients, but her teaching and mentoring has inspired and empowered a new generation of nutrition specialists and health professionals.

In today’s episode, we welcome Dr. Sheila Dean back to the show for a masterclass in hormone detoxification – including the importance of testing and clinical pearls using nutritional therapeutics.

Today on The Lab Report:

• 3:20 Dr. Dean is back with a detox pathway recap
• 7:20 Importance of hormone detox
• 11:10 The need for testing metabolites
• 16:30 Clinical pearls for optimizing estrogen metabolism
• 21:45 Role of Genetic SNPs and the microbiome
• 28:30 IFNA program highlights
• 30:35 The Fireball

Additional Resources:

Integrative and Functional Nutrition Academy

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

After years of working with collegiate and professional athletes, Pratik Patel has gained significant wisdom when it comes to optimal health. The continuous strain placed on the body of professional athletes can take its toll. Keeping those athletes healthy is no easy task. Pratik has worked with some of the most elite athletes in the world.

In today’s episode, dietitian and conditioning coach, Pratik Patel, reflects on his years in the NFL and imparts his wisdom regarding nutrition, hydration, strength training, recovery, and overall athletic health.

Today on The Lab Report:

• 4:00 Pratik Patel on great athletes vs. elite athletes
• 8:15 Genetics and work ethic
• 11:20 Lab testing, does fitness = health?
• 19:25 Hydration, thirst, and performance
• 25:00 Climate adaptability and electrolytes
• 31:00 Caffeine and hydration
• 34:00 Diet principles for athletes
• 38:35 Training pitfalls
• 41:10 Recommended supplements
• 49:35 Working with Pratik
• 51:00 The Fireball

Additional Resources:

Instagram:          @pratikxpatel

Twitter:                @PratikxPatel

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

Interpreting the GI Effects Comprehensive Stool Profile can be complicated. Here at Genova, we do a lot of educational outreach, one-on-one consults, group consults, and we compile lots of support materials to help – support guides, report review videos, charts, and more. Even with that, some clinicians still continue to misinterpret biomarker results and draw conclusions on their own which may not be valid.

In today’s episode, we dive into some of the GI Effects’ most common interpretation mistakes to dispel the rumors and help clinicians find the best outcomes for their patients.

Today on The Lab Report:

• 5:00 Products of Protein Breakdown and digestion/absorption
• 8:30 Commensal bacteria - below detectable limits?
• 12:20 When to treat a potential pathogen?
• 13:15 Salmonella pronunciation and etymology
• 19:15 Misusing Add-ons
• 22:50 Beta-glucuronidase and calcium-d-glucarate

Additional Resources:

GI Effects Support Guide

Commensal Bacteria Chart

Parasitic Organisms Chart

Pathogenic Bacteria and Yeast Chart

GI Effects Report Review Video

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

Amino acids are the building blocks of life. They can be categorized as essential or nonessential. Essential amino acids must come from the diet, while nonessential amino acids can be made in the body. Of the essential amino acids, there is a subgroup called the ‘branched-chain amino acids (BCAAs).’ There are three BCAAs: leucine, isoleucine, and valine. These three amino acids have different molecular structures and important metabolic activity.

In this episode, we discuss the clinical importance of BCAA and how to interpret BCAA levels in context with organic acids.

Today on The Lab Report:

• 2:50 Let’s Define Some Terms!
• 5:10 The unique metabolism of BCAAs
• 6:30 BCAAs effects on the brain, muscle, and insulin resistance
• 12:30 What do we think we know?
  • BCAAs and immunity
• 16:10 Measuring and interpreting amino acid patterns
• 17:55 Relating BCAA levels to urinary organic acids
• 21:00 Logical Speculation: Urinary alpha-keto acids and ketosis

Additional Resources:

NutrEval

Metabolomix +

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

In last week’s episode, we did a high-level review of nutrient testing – who might need it and why. We also introduced you to Genova’s Metabolomix+ profile. This nutritional profile is a non-invasive at-home collection with easy, actionable nutrient recommendations you can start implementing right away tailored for your personal metabolic fingerprint!

Today we dive a bit deeper into the biochemistry and biomarkers that are measured on the Metabolomix+ profile which contribute to the nutrient recommendations. Functional assessments, organic acids, amino acids, fatty acids, oxidative stress, and more!

Today on The Lab Report:

• 3:15 Recap of last episode Metabolomix overview and introducing the MHR Masterclass
• 6:00 Krebs Cycle and cellular energy
• 8:45 Organic Acids and functional assessments
• 11:20 Amino acids – essential, non-essential, and amino acid metabolism
• 14:30 Essential and Metabolic Fatty acids
• 16:10 Better Know a Biomarker
  • DGLA and the inflammatory cascade
• 23:15 Urine Toxic Elements

Additional Resources:

Genova Connect - Metabolomix+

Register Here for the Metabolic Health Revolution

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

We know nutrition is important. But with all of the confusion around different diet camps out there, (Mediterranean, paleo, vegetarian, keto) many of us don’t know where to start. How do we know if we’re getting proper nutrition to keep us healthy? Are you keeping up with how your body uses nutrients due to exercise, growth, or wound healing? Is a nutrient insufficiency causing your depression or fatigue? Are you setting yourself up for cellular stresses and potentially chronic disease? Food diaries can help but sometimes they fall short.  Here’s where testing can help.

Today we discuss the power of Genova’s Metabolomix+. This nutritional profile is a non-invasive at-home collection with easy, actionable recommendations you can start implementing right away tailored for your personal metabolic fingerprint!

Today on The Lab Report:

• 3:15 Who needs a nutrition test?
• 6:00 Intro to the Metabolomix+ Profile
• 8:45 Nutrition underpins bodily functions
• 12:25 Personalized nutrient recommendations
• 14:40 Education and food sources on the report
• 17:20 Question of the Day
  • Do I have to stop my supplements to do testing?

Additional Resources:

Genova Connect - Metabolomix+

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

Rachel Gregory is a board-certified nutrition specialist, strength and conditioning coach, podcaster, author, and founder of MetFlex Life. She inspires and guides women to transform their lives through proper education, awareness, and accountability in nutrition and fitness. Through her unique approach, she helps women all across the world learn how to ditch the restrictive all-or-nothing mindset and instead thrive through the power of metabolic flexibility.

In today’s episode, Rachel Gregory returns to the show and we catch up on her amazing coaching programs, education, and her latest insights relating to women’s health.

Today on The Lab Report:

• 4:00 Rachel Gregory is back, and she’s been busy!! 
• 8:35 Change of focus to holistic women’s health and common pitfalls
• 15:00 Using keto as a tool vs. pulsating carbs
• 18:40 Long-term planning and periodization
• 21:00 Training to build muscle instead of weight loss
• 24:25 Wearable devices
• 27:05 The role of carbohydrates 
• 29:40 Correctly building muscle
• 37:40 Will there be another book?
• 38:50 The Fireball

Additional Resources:

MetFlex Life

TheFlexFam

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

There is a lot of debate and controversy when it comes to nutrition. Many of us are entrenched in our diet camps and with that, some nutrients are unfairly vilified. One such nutrient is phytoestrogen. Phytoestrogens are chemical compounds found in plants that can stimulate and block estrogen receptors in the body – a concept that is poorly misunderstood.

In today’s episode, we talk about phytoestrogens and their metabolic function. Should they be classified as anti-nutrients? Are they dangerous or protective?

Today on

• 3:20 Phytoestrogens and anti-nutrients
• 5:07 Types of phytoestrogens and common food sources
• 7:55 Are we actually eating estrogen?
• 9:30 Constituent vs. whole plant
• 12:00 Hormone-related risks and PMS
• 13:32 Cardiovascular disease
• 14:30 Logical Speculation – Just eat food
• 17:00 Tumors, bone, brain, and skin  

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.