The Lab Report

We live in a toxic world. Every day we are exposed to an array of environmental toxins in our air, water, soil, and food. Luckily, our body is well-equipped to handle most of them. Additionally, there are things we can do to help optimize the body’s detoxification process. Not only should we try to avoid toxins whenever possible, but we can also support the process of detoxification by focusing on nutrition, the GI tract, our skin, and proper hydration.

In today’s episode, we review steps in the body’s process of detoxification and speak to Dr. Christine Stubbe of Genova’s Medical Affairs team on her personal detox protocol.

Today on The Lab Report:

• 3:00 Exposures and the bucket analogy
• 5:30 Weight loss and toxin release
• 6:25 Physiologic steps of detoxification
• 10:35 Getting specific on detox protocols with Dr. Stubbe
• 16:25 The importance of preparation 
• 19:45 Christine’s daily protocol
• 36:30 Question of the Day
  • Which Genova testing profiles give insight into detox potential?

Additional Resources:

GI Effects Stool Profile

Methylation Panel

Detoxigenomic Profile

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Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

Our daily lives are filled with toxic exposures which can affect our health. Luckily, our bodies are well-quipped to handle and detoxify most of them. However, excessive exposures can lead to some subtle clinical presentations and eventually serious physical side effects.

In today’s episode, we discuss the sources of three common metal exposures, their physiologic importance, and how to test for them.

Today on The Lab Report:

• 3:05 Biotransformation -defining terms
• 7:00 Why do we care about heavy metal exposures?  
• 9:05 Lead
• 13:30 Mercury
• 16:50 Arsenic
• 20:15 Genova testing options
• 24:20 Question of the Day:
  • What form of mercury is being measured on the NutrEval?

Additional Resources:

Agency for Toxic Substances and Disease Registry (ATSDR)

NutrEval

Elemental Analysis

Comprehensive Urine Elements Profile

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

Drew Manning is a health and fitness expert who became a world-wide sensation with his Fit2Fat2Fit experiment years ago. He gained and lost 75 pounds on purpose to understand the psychology of weight loss and bring empathy to the fitness industry. Currently, he is in the midst of repeating this feat as he turned forty years old in his Fit2Fat2Forty experiment. 

Drew is halfway through after gaining 60 pounds and is about to journey back to fit. Today we check in on how he’s feeling and discuss what he’s learned so far.

Today on The Lab Report:

• 4:35 Drew Manning discusses the physical and emotional toll of weight gain
• 8:25 Empathy  
• 9:25 The difference after turning 40
• 11:05 Social media influence
• 13:05 The effects of ‘dirty diets’
• 16:00 Preparing for the journey back to fit
• 18:40 Television series? Book? Documentary?  
• 19:35 The Fireball

Additional Resources:

Back2Fit

Fit2Fat2Fit Experience Podcast

Fit2Fat2Fit: The Unexpected Lessons from Gaining and Losing 75lbs on Purpose

Complete Keto

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

As the year 2020 comes to a close, Patti and Michael reflect back on the past year of The Lab Report podcast, which is approaching one year old. This new educational platform was created to spread the word about functional medicine and promote a focus on health and wellness. Throughout the year, we’ve covered many topics and interviewed some amazing guests. We laughed a lot and learned so much along the way.

As we head into the New Year, many people make resolutions to improve their health. In today’s episode we reflect on past shows and highlight some clinical pearls to help guide you into a healthy 2021.

Today on The Lab Report:

• 2:25 Back to the very beginning
• 5:10 What did we learn about diets?
• 13:00 Who doesn’t love jingles?
• 14:35 Movement, exercise, and motivation
• 19:55 Mindfulness and stress
• 23:00 Ok, now what? Where do you start?

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

Dr. Austin Perlmutter is a board-certified internal medicine physician and New York Times best-selling author of the book Brain Wash. He has a special interest in helping patients understand their decisions and behavior as it relates to improving their health. Understanding unconscious habits and how the brain processes our environment is pivotal when it comes to helping patients and guiding their treatment – especially as many of us are making New Year’s resolutions.

In today’s episode, Dr. Perlmutter explains the ‘why’ behind our unhealthy decision-making and offers some strategies to change our behavior.

Today on The Lab Report:

• 2:40 Meet Dr. Perlmutter and learn about his focus on the brain
• 6:40 Prioritizing what’s good for us – knowledge, willpower, and blame
• 10:40 Freedom of choice and unconscious habits
• 15:30 Breaking the cycle of bad habits for the New Year
• 18:55 The effect of social media and news distractions
• 22:30 Protecting our brain – Brain Wash
• 27:45 The immune system beyond infectious disease
• 32:25 The Fireball

Additional Resources:

Brain Wash: Detox Your Mind for Clearer Thinking, Deeper Relationships, and Lasting Happiness

The Modern Brain - Psychology Today

drperlmutter.com

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

We tend to lean on traditions during the holiday season. As they are handed down through the generations, their origins are often forgotten. Not only do traditions offer comfort and help to unify us, but many also have important health benefits.

Today we have some fun with the origins of several holiday traditions and weave in their clinical significance. Make sure to stay tuned for a special Genova version of ‘Twas the Night Before Christmas!

Today on The Lab Report:

• 2:50 Mistletoe – antioxidants and smoochie smoochie
• 5:00 Pine, conifers, and evil spirits
• 7:35 Peppermint candy canes and carminatives
• 10:35 Checking in with the UK – Oliver’s fear of figgy pudding
• 14:40 Gingerbread houses made from the super-herb
• 17:40 Gift-giving and ‘Off the Cuff’ with the Medical Affairs team
• 24:55 ‘Twas the Night Before Christmas ???????

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

Vitamin D is a fat-soluble vitamin with important physiologic effects. Unlike other vitamins that must be obtained from the diet, vitamin D can also be produced in the skin from sunlight. The health implications of vitamin D have been widely studied and some of these effects might surprise you.  

In today’s episode, we describe how vitamin D is metabolized and why it is clinically important in the body. We also discuss supplementation and the confusion around optimal levels.

Today on The Lab Report:

• 2:45 Let’s define some terms!
• 5:10 Metabolism and activation of vitamin D
• 6:30 Difference between vitamin D₂ and D₃
• 8:50 The role of sunlight
• 10:00 VDRs, calcium homeostasis, and immunity
• 14:50 Vitamin D in glucose metabolism and effects in the brain
• 17:30 What are optimal levels?
• 20:45 Question of the Day:
  • Can you get too much vitamin D?

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

In functional medicine, we often discuss behavioral change. But this can be difficult since many of us don’t like to be pushed out of our comfort zone. Dr. Alex Hutchinson is a physicist, endurance athlete, and author who writes about the perception of limits. How much of our physical limitations are real? Is it possible our minds are the actual limiting factor?

In today’s episode, Alex discusses his work on the human body’s capacity to endure. We talk about pain’s role in setting limits, and the psychology of pushing beyond what we think is possible.

Today on The Lab Report:

• 2:50 Meet Dr. Alex Hutchinson - from physics to journalism
• 7:45 Why is it so hard to be pushed out of our comfort zone?
• 10:00 Physical vs. mental limitations and the role of pain
• 15:30 Practical tips to understand and set limits
• 22:30 Nature vs. nurture
• 25:20 Malcolm Gladwell
• 28:00 The Fireball

Additional Resources:

ENDURE

Which Comes First, Cardio or Weights?

Big Ideas: 100 Modern Inventions That Have Transformed Our World

Sweat Science

Jockology

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

Amino acids are the building blocks of life. They can be categorized as being essential or nonessential. Essential amino acids must come from the diet, while nonessential amino acids can be made in the body. Of the essential amino acids, there is a subgroup called the ‘branched chain amino acids (BCAAs).’ There are three BCAAs: leucine, isoleucine, and valine. These three amino acids have different molecular structures and important metabolic activity.

In this episode, we discuss the clinical importance of BCAA and how to interpret BCAA levels in context with organic acids.

Today on The Lab Report:

• 2:50 Let’s Define Some Terms!
• 5:10 The unique metabolism of BCAAs
• 6:30 BCAAs effects on the brain, muscle, and insulin resistance
• 12:30 What do we think we know?
  • BCAAs and immunity
• 16:10 Measuring and interpreting amino acid patterns
• 17:55 Relating BCAA levels to urinary organic acids
• 21:00 Logical Speculation: Urinary alpha-keto acids and ketosis

Additional Resources:

NutrEval

Metabolomix +

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.

Many of us know insulin as the hormone that regulates our blood sugar. We often think of its role in diabetes. However, insulin affects far more than glucose. Dr. Ben Bikman is a PhD researcher who has been studying insulin for many years. His latest book, Why We Get Sick, outlines how insulin resistance is at the root of chronic disease and ways to treat and prevent it.

In this episode, we speak to Dr. Bikman about the mechanisms of insulin resistance, its far-reaching effects in chronic disease, and strategies to improve it.

Today on The Lab Report:

• 2:20 Meet Dr. Bikman and learn why he focuses his research on insulin
• 8:35 Insulin and insulin resistance  
• 13:55 Where in the body does insulin resistance start?
• 18:25 Hypertrophic vs. hyperplastic fat cells and the effects of free fatty acids
• 26:35 Signals that create hypertrophic vs. hyperplastic fat cells
• 28:45 Muscle-centric model of insulin resistance
• 32:15 Chronic diseases as they relate to insulin resistance
• 35:50 Aromatase activity in adipose tissue
• 37:25 The brain and Alzheimer’s disease as ‘type 3 diabetes’?
• 41:50 Fasting, ketosis, and lifestyle strategies to combat insulin resistance
• 47:35 COVID-19, immunity, and metabolic defenses
• 50:40 The Fireball

Additional Resources:

Why We Get Sick

Ceremides as modulators of cellular and whole-body metabolism

Adipose Tissue as an Endocrine Organ

Ketones Elicit Distinct Alterations in Adipose Mitochondrial Bioenergetics

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

See omnystudio.com/listener for privacy information.