The Medici family are approaching the brink of extinction. It's up to Cosimo III's three children to preserve the family, but even with the dynasty's survival on the line, the Medici cannot stop themselves from repeating the mistakes of the recent past.

Cosimo and Marguerite-Louise's dysfunctional marriage hits its dramatic crescendo and falls apart. Will Marguerite-Louise escape back to her homeland, or will she remain a prisoner of her despised husband?

Grand Duke Cosimo III sets out to make Tuscany great again with tariffs and religiosity. At the same time, Cosimo aims for royal glory, even at a time all of Italy is under the boot of the Hapsburgs.

Ferdinando II had high hopes that marrying his introverted, overly devout son to a French princess would both loosen his son up and save the dynasty from extinction. Things wouldn't turn out quite like he wanted.

Despite his unorthodox love life, Ferdinando II is well-liked for his genuine concern for his people and his scientific patronage. However, Tuscany is in decline, and the seeds for the dynasty's extinction have already been planted.

Cosimo II finally dies after a prolonged illness. Meanwhile, the Church loses its patience with Galileo.

Why was Galileo's scientific work considered both something worth celebrating and a threat to the status quo? Galileo himself must have pondered that question as his work, celebrated as it was by the Medici and even high-ranking members of the Church, nonetheless caught the attention of the Roman Inquisition.

The celebrity natural philosopher and writer Galileo rises out of a life of near-poverty to become a favorite at the Medici court. But when controversy rears its head, will the Medici actually protect the quarrelsome Galileo?

After his brother's hands-off approach to ruling, Grand Duke Ferdinando I instead tends to the economic health of his state and his people.

Marie de' Medici believes she finally triumphed over her protege turned archenemy Richelieu and has secured her place as Louis XIII's benevolent advisor. As the proverb goes, though, pride goeth before a fall...