The latest information and guideline updates that healthcare professionals need to know for their practice are included in the recent AHA/ACC/Multisociety Blood Cholesterol Guidelines. These guidelines also introduce female-specific risk enhancers to help assess cardiovascular risk in women and discuss several new options for lowering LDL-C. Also examined is the new treatment option available for those with elevated triglyceride levels at risk of ASCVD events. The results from the REDUCE-IT trial on icosapent ethyl have led to new FDA indications and updates to many guidelines that now incorporate its use for patients with a high risk of a serious event and an elevated triglyceride level. The key takeaway from this expert dialogue is that lipid management has been redefined.