Oprah is opening the vault of The Oprah Winfrey Show with 25 years of hand-picked legendary interviews, a-ha moments, ugly cries and unforgettable surprises. A lot has changed since she ended the show, but many of our personal struggles have stayed the same. We’re all still looking to connect, to be seen and to know that we’re not alone. We’re also looking for some joy, some laughs and some much-needed inspiration. As we head into this new decade, what better time to look back and reflect, to take stock of how we’ve grown and to be reminded that we’re all in this together. The Oprah Winfrey Show aired from September 8th, 1986 to May 25, 2011 with 4,561 episodes. The show remains the highest-rated daytime talk show in American television history, averaging between 10 to 20 million viewers a day.